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Reversibility of Ischemic Brain Damage
Abstract
The susceptibility of the brain to anoxia is considered to be the limiting factor for resuscitation after transient circulatory arrest, both in clinical and experimental conditions.1,2In the classic experiments of Weinberger et al,3Kabat et al,4Grenell,5Hirsch et al,6and others, the upper limit for full recovery was found to be three to four minutes of cardiocirculatory arrest, and eight to ten minutes of isolated cerebrovascular arrest. The high sensitivity of the central nervous tissue to ischemia has been attributed to low reserves in substrates suitable for anaerobic energy metabolism, because a close correlation was found between the depletion of energy-rich phosphates and the irreversibility of brain damage.7This concept, however, is difficult to reconcile with more recent demonstrations of the recovery of various neuronal functions after time intervals which by far exceed the limit of energy depletion. Examples are the return
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Citations
Cited by
Pathophysiology and treatment of focal cerebral ischemia: Part I: Pathophysiology
Siesjö, B. K. (1992) · Journal of Neurosurgery · doi:10.3171/jns.1992.77.2.0169 · Cited by 1,295
Selective vulnerability of the hippocampus in brain ischemia
Schmidt-Kastner, R., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90001-5 · Cited by 888
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury
White, B. C., Sullivan, J. M., DeGracia, D. J., O’Neil, B. J., Neumar, R. W., Grossman, L. I., Rafols, J. A., & Krause, G. S. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00386-5 · Cited by 796
Rodent models of cerebral ischemia.
Ginsberg, M. D., & Busto, R. (1989) · Stroke · doi:10.1161/01.str.20.12.1627 · Cited by 659
Brain Lactic Acidosis and Ischemic Cell Damage: 1. Biochemistry and Neurophysiology
Rehncrona, S., Rosén, I., & Siesjö, B. K. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.34 · Cited by 586
Metadata
- Authors
- Hossmann, K.-A., & Kleihues, P.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1973-12-01
- Volume
- 29
- Issue
- 6
- Pages
- 375-384
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2034807801
- Cited by
- 463
- References
- 0
- FWCI
- 23.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hossmann, K.-A., & Kleihues, P. (1973). Reversibility of Ischemic Brain Damage. Archives of Neurology. https://doi.org/10.1001/archneur.1973.00490300037004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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