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Pathogenesis of Lead Encephalopathy: Uptake of Lead and Reaction of Brain Capillaries
Abstract
Lead entry Into the central nervous system and effects on brain metabolism were studied in immature rats. Lead 210 readily enters the brain after intravenous injection; uptake is proportional to dose. Although blood levels fall rapidly after injection, brain lead retention is prolonged and unaffected by edetic acid therapy. In individuals who ingest lead episodically, progressive accumulation in the brain can occur without detection of changes in blood. Excessive lead deposition in the brain of nursing rat pups provokes severe hemorrhagic reactions limited to the cerebellum although lead concentrations are the same as in other brain regions. A prehemorrhagic stage of lead encephalopathy could be identified in the cerebellum by monitoring brain edema. This appears to be due to capillary dysfunction and suggests that cerebellar capillaries are more vulnerable to lead than capillaries elsewhere in the brain.
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Citations
Cited by
Longitudinal Analyses of Prenatal and Postnatal Lead Exposure and Early Cognitive Development
Bellinger, D., Leviton, A., Waternaux, C., Needleman, H., & Rabinowitz, M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704233161701 · Cited by 855
Brain barrier systems: a new frontier in metal neurotoxicological research
Zheng, W., Aschner, M., & Ghersi-Egea, J.-F. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00251-5 · Cited by 507
Mechanisms of lead neurotoxicity
Bressler, J. P., & Goldstein, G. W. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90617-e · Cited by 403
Self-citationRecommendations for Medical Management of Adult Lead Exposure
Kosnett, M. J., Wedeen, R. P., Rothenberg, S. J., Hipkins, K. L., Materna, B. L., Schwartz, B. S., Hu, H., & Woolf, A. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9784 · Cited by 358
Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions
Strużyńska, L., & Sulkowski, G. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.02.010 · Cited by 74
Metadata
- Authors
- Goldstein, G. W.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1974-12-01
- Volume
- 31
- Issue
- 6
- Pages
- 382
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2049463945
- Cited by
- 168
- References
- 0
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goldstein, G. W. (1974). Pathogenesis of Lead Encephalopathy: Uptake of Lead and Reaction of Brain Capillaries. Archives of Neurology. https://doi.org/10.1001/archneur.1974.00490420048005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
