The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Recommendations for Medical Management of Adult Lead Exposure
Open accessAbstract
Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a body of published literature that establishes the potential for hypertension, effects on renal function, cognitive dysfunction, and adverse female reproductive outcome in adults with whole-blood lead concentrations < 40 microg/dL. Based on this literature, and our collective experience in evaluating lead-exposed adults, we recommend that individuals be removed from occupational lead exposure if a single blood lead concentration exceeds 30 microg/dL or if two successive blood lead concentrations measured over a 4-week interval are > or = 20 microg/dL. Removal of individuals from lead exposure should be considered to avoid long-term risk to health if exposure control measures over an extended period do not decrease blood lead concentrations to < 10 microg/dL or if selected medical conditions exist that would increase the risk of continued exposure. Recommended medical surveillance for all lead-exposed workers should include quarterly blood lead measurements for individuals with blood lead concentrations between 10 and 19 microg/dL, and semiannual blood lead measurements when sustained blood lead concentrations are < 10 microg/dL. It is advisable for pregnant women to avoid occupational or avocational lead exposure that would result in blood lead concentrations > 5 microg/dL. Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations.
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Cites
Lead Exposure and Cardiovascular Disease—A Systematic Review
Navas-Acien, A., Guallar, E., Silbergeld, E. K., & Rothenberg, S. J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9785 · Cited by 1,112
Self-citationTubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure
Åkesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Strömberg, U., & Skerfving, S. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8033 · Cited by 465
Blood Lead Below 0.48 μmol/L (10 μg/dL) and Mortality Among US Adults
Menke, A., Muntner, P., Batuman, V., Silbergeld, E. K., & Guallar, E. (2006) · Circulation · doi:10.1161/circulationaha.106.628321 · Cited by 451
Mahaffey, K. R., Annest, J. L., Roberts, J., & Murphy, R. S. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209023071001 · Cited by 444
Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
Hu, H., Téllez-Rojo, M. M., Bellinger, D., Smith, D., Ettinger, A. S., Lamadrid-Figueroa, H., Schwartz, J., Schnaas, L., Mercado-García, A., & Hernández-Avila, M. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9067 · Cited by 366
Self-citationRogan, W. J., Dietrich, K. N., Ware, J. H., Dockery, D. W., Salganik, M., Radcliffe, J., Jones, R. L., Ragan, N. B., Chisolm, J. J., & Rhoads, G. G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441902 · Cited by 361
Blood Lead Levels and Mortality
Lustberg, M., & Silbergeld, E. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.21.2443 · Cited by 332
Hu, H., Shih, R., Rothenberg, S., & Schwartz, B. S. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9783 · Cited by 306
Self-citationReduced Intellectual Development in Children with Prenatal Lead Exposure
Schnaas, L., Rothenberg, S. J., Flores, M.-F., Martinez, S., Hernandez, C., Osorio, E., Velasco, S. R., & Perroni, E. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8552 · Cited by 305
Self-citationSchober, S. E., Mirel, L. B., Graubard, B. I., Brody, D. J., & Flegal, K. M. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9123 · Cited by 292
Cited by
Wani, A. L., Ara, A., & Usmani, J. A. (2015) · Interdisciplinary Toxicology · doi:10.1515/intox-2015-0009 · Cited by 1,964
Trace Elements in Human Nutrition (II)—An Update
Mehri, A. (2020) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_48_19 · Cited by 395
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
Wright, R. O., Schwartz, J., Wright, R. J., Bollati, V., Tarantini, L., Park, S. K., Hu, H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901429 · Cited by 235
Self-citationAnemia risk in relation to lead exposure in lead-related manufacturing
Hsieh, N.-H., Chung, S.-H., Chen, S.-C., Chen, W.-Y., Cheng, Y.-H., Lin, Y.-J., You, S.-H., & Liao, C.-M. (2017) · BMC Public Health · doi:10.1186/s12889-017-4315-7 · Cited by 88
Metadata
- Authors
- Kosnett, M. J., Wedeen, R. P., Rothenberg, S. J., Hipkins, K. L., Materna, B. L., Schwartz, B. S., Hu, H., & Woolf, A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-03
- Volume
- 115
- Issue
- 3
- Pages
- 463-471
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1967966154
- Cited by
- 358
- References
- 59
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- gold
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