The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Role of Glutamate in Neurotransmission and in Neurologic Disease
Abstract
Glutamate is the putative neurotransmitter of several clinically important pathways, including cortical association fibers, corticofugal pathways such as the pyramidal tract, and hippocampal, cerebellar, and spinal cord pathways. The excitatory actions of glutamate are mediated by multiple, distinct receptor types and potent receptor antagonists have recently been developed. Glutamate also has neurotoxic properties and can produce "excitotoxic" lesions reminiscent of human neurodegenerative disorders. Abnormally enhanced glutamatergic neurotransmission may cause excitotoxic cell damage and lead to the neuronal death associated with olivopontocerebellar atrophy, Huntington's disease, status epilepticus, hypoxia/ischemia, and hypoglycemia. Pharmacologic manipulation of the glutamatergic system may have great potential for the rational treatment of a variety of neurologic diseases.
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Cites
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Acute dendrotoxic changes in the hippocampus of kainate treated rats
Olney, J. W., Fuller, T., & De Gubareff, T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90872-2 · Cited by 300
Cited by
Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels
Teitelbaum, J. S., Zatorre, R. J., Carpenter, S., Gendron, D., Evans, A. C., Gjedde, A., & Cashman, N. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006213222505 · Cited by 555
Danysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404
Glutamate and Parkinson’s disease
Blandini, F., Porter, R. H. P., & Greenamyre, J. T. (1996) · Molecular Neurobiology · doi:10.1007/bf02740748 · Cited by 323
Self-citation
Metadata
- Authors
- Greenamyre, J. T.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1986-10-01
- Volume
- 43
- Issue
- 10
- Pages
- 1058-1063
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2160191383
- Cited by
- 295
- References
- 3
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
