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Striatal Dysfunction in Attention Deficit and Hyperkinetic Disorder
Abstract
We have previously reported that periventricular structures are hypoperfused in attention deficit and hyperactivity disorder (ADHD). This study has expanded the number of patients, who were divided into two groups: six patients with pure ADHD, and 13 patients with ADHD in combination with other neurologic symptoms. By using xenon 133 inhalation and emission tomography, the regional cerebral blood flow distribution was determined and compared with a control group. Striatal regions were found to be hypoperfused and, by inference, hypofunctional in both groups. This hypoperfusion was statistically significant in the right striatum in ADHD, and in both striatal regions in ADHD with other neuropsychologic and neurologic symptoms. The primary sensory and sensorimotor cortical regions were highly perfused. Methylphenidate increased flow to striatal and posterior periventricular regions, and tended to decrease flow to primary sensory regions. Low striatal activity, partially reversible with methylphenidate, appears to be a cardinal feature in ADHD.
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Cited by
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580
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Pennington, B. F., & Ozonoff, S. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01380.x · Cited by 3,150
Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder
Castellanos, F. X. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070053009 · Cited by 1,183
Diamond, A. (2000) · Child Development · doi:10.1111/1467-8624.00117 · Cited by 1,175
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131
Metadata
- Authors
- Lou, H. C., Henriksen, L., Bruhn, P., Borner, H., & Nielsen, J. B.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1989-01-01
- Volume
- 46
- Issue
- 1
- Pages
- 48-52
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2104685833
- Cited by
- 549
- References
- 0
- FWCI
- 17.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lou, H. C., Henriksen, L., Bruhn, P., Borner, H., & Nielsen, J. B. (1989). Striatal Dysfunction in Attention Deficit and Hyperkinetic Disorder. Archives of Neurology. https://doi.org/10.1001/archneur.1989.00520370050018
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