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Cited by 193Amyotrophic Lateral Sclerosis ResearchCancer survivorship and careNeurogenetic and Muscular Disorders Research

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Survival in Amyotrophic Lateral Sclerosis: The Role of Psychological Factors

McDonald, Evelyn R.·1994·Archives of Neurology
DOI 10.1001/archneur.1994.00540130027010
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Abstract

OBJECTIVE: Examining the relationship between psychological status and survival in amyotrophic lateral sclerosis. Our hypothesis is that psychological distress is associated with greater mortality and shorter survival time than psychological well-being. DESIGN: Cross-sectional, longitudinal. The baseline evaluations used were disease severity and 10 psychometric tests. A psychological status score was derived from these tests. Survival status was monitored for 3.5 years. Interviewers were blinded to other interviews and data analysis. SETTING: Patient's residence. PATIENTS: The criteria for eligibility were diagnosis of amyotrophic lateral sclerosis by a neurologist, dementia or alcoholism absent, communication in English, and any severity or length of disease. It was a volunteer sample consisting of 144 patients from amyotrophic lateral sclerosis clinics or community-based amyotrophic lateral sclerosis support groups. In this sample 66% were men, 94% were white, mean age at diagnosis was 55 years, 79% were married, 60% had some college education, and 61% died during the study. INTERVENTIONS: None. END POINTS: mortality during study, survival time from intake to last follow-up. RESULTS: Comparison between high and low psychological score groups: 32% of high and 82% of low died; survival curves were significantly different. Controlling for confounding factors (length of illness, disease severity, age), patients with psychological distress had a greater risk of mortality (relative risk, 6.76; 95% confidence limits, 1.69 to 27.12) and greater likelihood of dying in any given time period (relative risk, 2.24; 95% confidence limits, 1.08 to 4.64) than those with psychological well-being. CONCLUSION: Adjusting for confounding factors, psychological status is strongly related to outcome in amyotrophic lateral sclerosis. Further studies on psychological status should be done to confirm its prognostic value.

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Crossref · 10.1001/archneur.1994.00540130027010

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Metadata

Authors
McDonald, E. R.
Corresponding author
McDonald, Evelyn R.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1994-01-01
Volume
51
Issue
1
Pages
17
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1994.00540130027010
OpenAlex
W1977988586
Cited by
193
References
49
Citations by year
2025: 3 · 2024: 4 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 11
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords
amyotrophic lateral sclerosis, psychological distress, psychological well-being, survival, mortality, prognostic factors, psychological state, disease severity, psychometric assessment
MeSH terms
Amyotrophic Lateral Sclerosis, Female, Humans, Male, Mental Health, Middle Aged, Psychiatric Status Rating Scales, Psychological Tests

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