The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Sleep Disruption in Parkinson's Disease: Assessment by Continuous Activity Monitoring
Abstract
OBJECTIVE: To assess differences in activity and immobility during sleep between patients with Parkinson's disease (PD) and healthy subjects and to evaluate the relations of clinical variables with the motor activity measures in patients with PD. DESIGN: Survey, case series. SETTING: University hospital outpatient neurology department and urban population in Leiden, the Netherlands. Motor activity was recorded during 6 successive nights at home with a wrist-worn activity monitor. PARTICIPANTS: Eighty-nine patients with PD and 83 age-matched healthy controls. MAIN OUTCOME MEASURES: For each subject, three mean measures reflecting activity or immobility during the nocturnal period were calculated. RESULTS: Compared with the healthy elderly subjects, patients with PD have an elevated nocturnal activity level and an increased proportion of time with movement, indicating a more disturbed sleep. The mean duration of nocturnal immobility periods was similar for both groups. This measure, however, did reflect the self-reported disturbed sleep maintenance in both groups. The daily dose of levodopa or the use of dopamine agonists in patients not receiving levodopa, rather than disease severity, proved to be the best predictors of nocturnal activity. CONCLUSIONS: We hypothesize that in mildly to moderately affected patients with PD, levodopa or dopamine agonists cause sleep disruption by their effects on sleep regulation. In more severely affected patients, the beneficial effects of these drugs on nocturnal disabilities that cause sleep disruption in PD prevail.
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“This reduced amplitude of the rest-activity cycle is present in both de novo and more advanced patients, and appears to be independent of the intake of dopaminergic medications (Piccini et al., 1991, Placidi et al., 2008, van Hilten et al., 1994, van Hilten et al., 1993, van Hilten et al., 1993).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as van Hilten et al., 1994
Citations
Cites
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The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow, C. W., Stern, M. B., & Sethi, K. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a1d44c · Cited by 947
The role of actigraphy in sleep medicine
Sadeh, A., & Acebo, C. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0182 · Cited by 743
An algorithm (decision tree) for the management of Parkinson’s disease (2001):
Olanow, C. W., Watts, R. L., & Koller, W. C. (2001) · Neurology · doi:10.1212/wnl.56.suppl_5.s1 · Cited by 724
A community‐based study of sleep disorders in patients with Parkinson's disease
Tandberg, E., Larsen, J. O., & Karlsen, K. (1998) · Movement Disorders · doi:10.1002/mds.870130606 · Cited by 447
Daytime sleepiness and other sleep disorders in Parkinson’s disease
Ondo, W. G., Vuong, K. D., Khan, H., Atassi, F., Kwak, C. H., & Jankovic, J. J. (2001) · Neurology · doi:10.1212/wnl.57.8.1392 · Cited by 386
Metadata
- Authors
- van Hilten, B.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1994-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 922
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2104533643
- Cited by
- 166
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Keywords
- Parkinson's disease, sleep disruption, wrist-worn activity monitors, levodopa, dopamine agonists, sleep maintenance, sleep regulation, disease severity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Motor Activity, Movement, Parkinson Disease, Sleep Wake Disorders
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