Cited by 444Parkinson's Disease Mechanisms and TreatmentsSleep and related disordersRestless Legs Syndrome Research

The DOI matches its Crossref record.

The Nighttime Problems of Parkinsonʼs Disease

Lees, Andrew J., Blackburn, Nigel A., Campbell, Vivien L.·1988·Clinical Neuropharmacology

Abstract

In a national survey conducted among 220 patients with Parkinson's disease (PD), 215 reported experiencing disabilities at night or on waking. The most common problems were inability to turn over or get out of bed and a frequent need to pass urine during the night. For the majority of patients, sleep was disrupted. Despite these difficulties, two-thirds of patients rated sleep quality as acceptable or good. The average duration of sleep was 6.5-7 h but approximately 8% of patients reported less than 5 h sleep per night. Hypnotic or sedative drugs were used by 29% of patients to help them sleep but only 6% took any antiparkinsonian medication during the night. Just over half the patients had told their doctor of nocturnal problems; prescription of hypnotic drugs or changes to antiparkinsonian therapy were the remedies most frequently tried. Problems at night are common in PD and, because of their debilitating effect on performance during the daytime, merit special attention.

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Crossref · 10.1097/00002826-198812000-00004

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Metadata

Authors
Lees, A. J., Blackburn, N. A., & Campbell, V. L.
Affiliations
  • University College Hospital (GB)
  • Roche (United Kingdom) (GB)
Venue
Clinical Neuropharmacology
Published
1988-12
Volume
11
Issue
6
Pages
512-519
ISSN
0362-5664 (ISSN-L)
OpenAlex
W1997144195
Cited by
444
References
0
Citations by year
2026: 5 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 19 · 2014: 19 · 2013: 25 · 2012: 19
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
Keywords
Parkinson's disease, nocturnal symptoms, sleep disruption, sleep quality, nocturia, bed mobility, hypnotics, antiparkinsonian drugs, sleep duration, patient survey
MeSH terms
Adult, Aged, Circadian Rhythm, Female, Humans, Male, Middle Aged, Movement Disorders, Parkinson Disease, Sleep Wake Disorders

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CoChat. (2026). Citation check: The Nighttime Problems of Parkinsonʼs Disease. https://app.cochat.ai/papers/10.1097/00002826-198812000-00004
The paper
Lees, A. J., Blackburn, N. A., & Campbell, V. L. (1988). The Nighttime Problems of Parkinsonʼs Disease. Clinical Neuropharmacology. https://doi.org/10.1097/00002826-198812000-00004