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The Nighttime Problems of Parkinsonʼs Disease
Abstract
In a national survey conducted among 220 patients with Parkinson's disease (PD), 215 reported experiencing disabilities at night or on waking. The most common problems were inability to turn over or get out of bed and a frequent need to pass urine during the night. For the majority of patients, sleep was disrupted. Despite these difficulties, two-thirds of patients rated sleep quality as acceptable or good. The average duration of sleep was 6.5-7 h but approximately 8% of patients reported less than 5 h sleep per night. Hypnotic or sedative drugs were used by 29% of patients to help them sleep but only 6% took any antiparkinsonian medication during the night. Just over half the patients had told their doctor of nocturnal problems; prescription of hypnotic drugs or changes to antiparkinsonian therapy were the remedies most frequently tried. Problems at night are common in PD and, because of their debilitating effect on performance during the daytime, merit special attention.
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“Other PD symptoms such as difficulties with turning around in bed, frequent nocturia, nocturnal tremor and depression may also lead to fractionated sleep (Lees et al. 1988).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Lees et al. 1988
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The clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410
Sleep Disruption in Parkinson's Disease: Assessment by Continuous Activity Monitoring
van Hilten, B. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210094018 · Cited by 166
The importance of non-motor disturbances to quality of life in Parkinson's disease
Martinez-Martin, P. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.05.006 · Cited by 160
Learning and consolidation of visuo-motor adaptation in Parkinson's disease
Marinelli, L., Crupi, D., Di Rocco, A., Bove, M., Eidelberg, D., Abbruzzese, G., & Ghilardi, M. F. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.02.012 · Cited by 129
Sleep Disturbances in Alzheimer’s and Parkinson’s Diseases
Rothman, S. M., & Mattson, M. P. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8181-2 · Cited by 102
Metadata
- Authors
- Lees, A. J., Blackburn, N. A., & Campbell, V. L.
- Affiliations
- University College Hospital (GB)
- Roche (United Kingdom) (GB)
- ORCID
- Lees, Andrew J.
- Venue
- Clinical Neuropharmacology
- Published
- 1988-12
- Volume
- 11
- Issue
- 6
- Pages
- 512-519
- ISSN
- 0362-5664 (ISSN-L)
- OpenAlex
- W1997144195
- Cited by
- 444
- References
- 0
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 19 · 2014: 19 · 2013: 25 · 2012: 19
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Keywords
- Parkinson's disease, nocturnal symptoms, sleep disruption, sleep quality, nocturia, bed mobility, hypnotics, antiparkinsonian drugs, sleep duration, patient survey
- MeSH terms
- Adult, Aged, Circadian Rhythm, Female, Humans, Male, Middle Aged, Movement Disorders, Parkinson Disease, Sleep Wake Disorders
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Nighttime Problems of Parkinsonʼs Disease. https://app.cochat.ai/papers/10.1097/00002826-198812000-00004
- The paper
- Lees, A. J., Blackburn, N. A., & Campbell, V. L. (1988). The Nighttime Problems of Parkinsonʼs Disease. Clinical Neuropharmacology. https://doi.org/10.1097/00002826-198812000-00004