CoChat
Sign Up
Cited by 166Parkinson's Disease Mechanisms and TreatmentsSleep and related disordersRestless Legs Syndrome Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Sleep Disruption in Parkinson's Disease: Assessment by Continuous Activity Monitoring

van Hilten, Bob·1994·Archives of Neurology
DOI 10.1001/archneur.1994.00540210094018
Open this paper in CoChat — free account

Abstract

OBJECTIVE: To assess differences in activity and immobility during sleep between patients with Parkinson's disease (PD) and healthy subjects and to evaluate the relations of clinical variables with the motor activity measures in patients with PD. DESIGN: Survey, case series. SETTING: University hospital outpatient neurology department and urban population in Leiden, the Netherlands. Motor activity was recorded during 6 successive nights at home with a wrist-worn activity monitor. PARTICIPANTS: Eighty-nine patients with PD and 83 age-matched healthy controls. MAIN OUTCOME MEASURES: For each subject, three mean measures reflecting activity or immobility during the nocturnal period were calculated. RESULTS: Compared with the healthy elderly subjects, patients with PD have an elevated nocturnal activity level and an increased proportion of time with movement, indicating a more disturbed sleep. The mean duration of nocturnal immobility periods was similar for both groups. This measure, however, did reflect the self-reported disturbed sleep maintenance in both groups. The daily dose of levodopa or the use of dopamine agonists in patients not receiving levodopa, rather than disease severity, proved to be the best predictors of nocturnal activity. CONCLUSIONS: We hypothesize that in mildly to moderately affected patients with PD, levodopa or dopamine agonists cause sleep disruption by their effects on sleep regulation. In more severely affected patients, the beneficial effects of these drugs on nocturnal disabilities that cause sleep disruption in PD prevail.

Overview

Integrity signals

Registry

Crossref · 10.1001/archneur.1994.00540210094018

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 41 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
van Hilten, B.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1994-09-01
Volume
51
Issue
9
Pages
922
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1994.00540210094018
OpenAlex
W2104533643
Cited by
166
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
Keywords
Parkinson's disease, sleep disruption, wrist-worn activity monitors, levodopa, dopamine agonists, sleep maintenance, sleep regulation, disease severity
MeSH terms
Adult, Aged, Aged, 80 and over, Antiparkinson Agents, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Motor Activity, Movement, Parkinson Disease, Sleep Wake Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review