A Clinicopathological Comparison of Community-Based and Clinic-Based Cohorts of Patients With Dementia
Open accessAbstract
Objectives To compare the sensitivity and specificity of the clinical diagnosis of Alzheimer disease, the distribution of pathological causes, and the demographic and clinical characteristics of 2 different groups of patients with dementia. Design Retrospective clinicopathological study. Setting A memory disorder clinic in a university hospital and a multiethnic community. Patients Sixty-three patients from a memory disorder clinic and 26 patients from a large community-based study who underwent autopsy after clinical evaluation. Main outcome measures Differential distribution of clinical and pathological findings, with clinicopathological correlations. Results Clinic patients were younger at diagnosis, more educated, and more likely to be white. Of the 63 clinic patients we evaluated, 29 (46%) had a pathological diagnosis of definite AD, 15 (24%) had a diagnosis of mixed AD, and 19 (30%) had a diagnosis of another type of dementia. The pathological diagnoses in the community patients were distributed as follows: 6 (23%) had definite AD, 6 (23%) had mixed AD, 6 (23%) had cerebrovascular disease, and 8 (31%) had another type of dementia. The difference in distribution of pathological diagnoses between these 2 groups was only significant for cerebrovascular diseases. For patients seen at the clinic, the sensitivity of the clinical diagnosis of AD was 98% and the specificity was 84%; for the community group, the sensitivity was 92% and the specificity was 79%. Conclusions The di…
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Clinic AD patients tend to suffer from fewer co-morbid conditions than population-ascertained AD cases.
“and tend to suffer from fewer co-morbid conditions.(7)”
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- Authors
- Massoud, F., Devi, G., Stern, Y., Lawton, A., Goldman, J. E., Liu, Y., Chin, S. S., & Mayeux, R.
- Affiliations
- Columbia University Irving Medical Center (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1999-11-01
- Volume
- 56
- Issue
- 11
- Pages
- 1368
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2114952717
- Cited by
- 91
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institutes of Health (5r35ag010963-04)
- National Institute on Aging (P01AG007232, AG 07232, AG10963)
- National Center for Research Resources (RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, dementia, clinicopathological correlation, community-based cohort, vascular dementia, autopsy pathology, diagnostic accuracy
- MeSH terms
- Age Factors, Aged, Alzheimer Disease, Autopsy, Catchment Area, Health, Community Health Services, Female, Humans, Male, Retrospective Studies, Sensitivity and Specificity, Cohort Studies
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