Diagnosis of Alzheimer's Disease
Abstract
Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research. The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further
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The original 1985 NIA criteria focused on age-related amyloid plaque density without regard to type of plaque.
“This contrasts to the original set of criteria produced in 1985 by the National Institute on Aging, which focused on age-related amyloid plaque density (with silver stains or thioflavin S fluorescent microscopy) without regard to type of plaque [108].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [108]
There have been several changes in neuropathological diagnostic criteria, including Khachaturian 1985, Tierney 1988, CERAD 1991, NIA-Reagan 1997.
“there have been several changes in neuropathological diagnostic criteria, including the “Khachaturian criteria” of 1985 (27), the “Tierney” criteria of 1988 (28), The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria in 1991 (29), and the National Institute on Aging (NIA)-Reagan criteria in 1997 (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [27]
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“This contrasts to the original set of criteria produced in 1985 by the National Institute on Aging, which focused on agerelated amyloid plaque density (with silver stains or thioflavin S fluorescent microscopy) without regard to type of plaque [108].”
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“All cases were categorized based on clinical and pathological criteria established by CERAD and an NIA consensus panel (Khachaturian 1985; Mirra et al. 1991).”
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Background
- Authors
- Khachaturian, Z. S.
- Corresponding author
- Khachaturian, Z. S.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1985-11-01
- Volume
- 42
- Issue
- 11
- Pages
- 1097-1105
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2171405125
- Cited by
- 2,499
- References
- 10
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 38 · 2021: 46 · 2020: 43 · 2019: 35 · 2018: 29 · 2017: 27 · 2016: 36 · 2015: 27 · 2014: 41 · 2013: 34 · 2012: 41
- FWCI
- 40.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- Alzheimer's disease, early diagnosis, dementia, neurochemistry, neuropathology, neuroradiology, neuropsychology
- MeSH terms
- Alzheimer Disease, Humans
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