Glutamate Transporters in Neurologic Disease

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

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Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

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El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

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Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

Olney, J. (1969) · Science · doi:10.1126/science.164.3880.719 · Cited by 1,885

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

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ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

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Primary structure and functional characterization of a high-affinity glutamate transporter

Kanai, Y., & Hediger, M. A. (1992) · Nature · doi:10.1038/360467a0 · Cited by 1,337

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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Cloning and expression of a rat brain L-glutamate transporter

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Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,197

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

Storck, T., Schulte, S., Hofmann, K., & Stoffel, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10955 · Cited by 1,193

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaught, M. P., & Amara, S. G. (1995) · Nature · doi:10.1038/375599a0 · Cited by 1,132

The release and uptake of excitatory amino acids

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The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

Lucas, D., & Newhouse, J. P. (1957) · Archives of Ophthalmology · doi:10.1001/archopht.1957.00940010205006 · Cited by 1,069

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

Arriza, J. L., Fairman, W. A., Wadiche, J. I., Murdoch, G., Kavanaugh, M. P., & Amara, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05559.1994 · Cited by 1,003

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

Arriza, J. L., Eliasof, S. D., Kavanaugh, M. P., & Amara, S. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4155 · Cited by 914

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

Ripps, M. E., Huntley, G. W., Hof, P. R., Morrison, J., & Gordon, J. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.689 · Cited by 725

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake

Szatkowski, M. S., Barbour, B., & Attwell, D. (1990) · Nature · doi:10.1038/348443a0 · Cited by 724

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

Lin, C.-L., Bristol, L. A., Jin, L., Dykes‐Hoberg, M., Crawford, T. O., Clawson, L., & Rothstein, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80997-6 · Cited by 672

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

Rothstein, J. D., Tsai, G. E., Kuncl, R. W., Clawson, L., Cornblath, D. R., Drachman, D. B., Pestronk, A., Stauch, B. L., & Coyle, J. T. (1990) · Annals of Neurology · doi:10.1002/ana.410280106 · Cited by 637

Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters

Hertz, L. (1979) · Progress in Neurobiology · doi:10.1016/0301-0082(79)90018-2 · Cited by 629

Mechanism of Transport and Storage of Neurotransmitter

Kanner, B. I., & Schuldiner, S. (1987) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238709082546 · Cited by 477

Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

Olney, J. W. (1971) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197101000-00008 · Cited by 416

Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine

Olney, J. W., & Ho, O. L. (1970) · Nature · doi:10.1038/227609b0 · Cited by 385

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

Trotti, D., Rolfs, A., Danbolt, N. C., Brown, R. H., & Hediger, M. A. (1999) · Nature Neuroscience · doi:10.1038/8091 · Cited by 373

Peroxynitrite Inhibits Glutamate Transporter Subtypes

Trotti, D., Rossi, D., Gjesdal, O., Levy, L. M., Racagni, G., Danbolt, N. C., & Volterra, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.5976 · Cited by 371

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

Shank, R. P., Gardocki, J. F., Vaught, J. L., Davis, C. B., Schupsky, J. J., Raffa, R. B., Dodgson, S. J., Nortey, S. O., & Maryanoff, B. E. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02459.x · Cited by 345

Glutamate transporter EAAC‐1‐deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration

Peghini, P., Janzen, J., & Stoffel, W. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3822 · Cited by 343

Hypoxia—ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

Martin, L. J., Brambrink, A. M., Lehmann, C. U., Portera‐Cailliau, C., Koehler, R. C., Rothstein, J. D., & Traystman, R. J. (1997) · Annals of Neurology · doi:10.1002/ana.410420310 · Cited by 271

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

Martin, D., Thompson, M. A., & Nadler, J. V. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90037-i · Cited by 262

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

Bristol, L. A., & Rothstein, J. D. (1996) · Annals of Neurology · doi:10.1002/ana.410390519 · Cited by 239

Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

Furuta, A., Martin, L. J., Lin, C.-L. G., Dykes‐Hoberg, M., & Rothstein, J. D. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00252-2 · Cited by 235

THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAIN

Olney, J. W. (1982) · Retina · doi:10.1097/00006982-198200000-00020 · Cited by 154

Modulation of non-vesicular glutamate release by pH

Billups, B., & Attwell, D. (1996) · Nature · doi:10.1038/379171a0 · Cited by 141

Expression of the glutamate transporters in human temporal lobe epilepsy

Tessler, S., Danbolt, N. C., Faull, R. L. M., Storm‐Mathisen, J., & Emson, P. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00301-7 · Cited by 112

Excitatory amino acids in amyotrophic lateral sclerosis: An update

Rothstein, J. D., Kuncl, R. W., Chaudhry, V., Clawson, L., Cornblath, D. R., Coyle, J. T., & Drachman, D. B. (1991) · Annals of Neurology · doi:10.1002/ana.410300223 · Cited by 96

Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity

Simantov, R., Crispino, M., Hoe, W., Broutman, G., Tocco, G., Rothstein, J. D., & Baudry, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00349-0 · Cited by 92

Chapter 19: Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue

Storm‐Mathisen, J., Danbolt, N. C., Rothe, F., Torp, R., Zhang, N., Aas, J., Kanner, B. I., Langmoen, I. A., & Ottersen, O. P. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61753-7 · Cited by 83

Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats

Akbar, M. T., Torp, R., Danbolt, N. C., Levy, L. M., Meldrum, B. S., & Ottersen, O. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00570-2 · Cited by 59

Expression of Two Glutamate Transporters, GLAST and EAAT4, in the Human Cerebellum: Their Correlation in Development and Neonatal Hypoxic-Ischemic Damage

Inage, Y. W., Itoh, M., Wada, K., & Takashima, S. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199806000-00003 · Cited by 57

Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS)

Niebrój-Dobosz, I., & Janik, P. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00717.x · Cited by 55

Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain.

Zhang, Y., Pines, G., & Kanner, B. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32207-x · Cited by 51

Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium

McDermott, R. H., & Butler, M. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.1.51 · Cited by 49

Increased transcription of glutamate–aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure

Nonaka, M., Kohmura, E., Yamashita, T., Shimada, S., Tanaka, K., Yoshimine, T., Tohyama, M., & Hayakawa, T. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00361-6 · Cited by 43

Differential Expressions of Glycine Transporter 1 and Three Glutamate Transporter mRNA in the Hippocampus of Gerbils with Transient Forebrain Ischemia

Fujita, H. M., Sato, K., Wen, T., Peng, Y., & Sakanaka, M. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199906000-00003 · Cited by 40

Biological markers in the diagnosis and treatment of ALS

Kalra, S., Arnold, D. L., & Cashman, N. R. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00023-4 · Cited by 34

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994

Kindling and status epilepticus models of epilepsy: rewiring the brain

Morimoto, K., Fahnestock, M. L., & Racine, R. J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.009 · Cited by 854

Astrocyte dysfunction in neurological disorders: a molecular perspective

Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 811

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Allanbutterfield, D., Castegna, A., Lauderback, C. M., & Drake, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00340-2 · Cited by 715

Glutamate transporter and neurodegenerative disorders

Yan, Y. (2003) · Zhongguo linchuang yaolixue yu zhiliaoxue

Glutamate transporters, excitotoxicity, and human neurodegenerative disease

Dodd, P. R., & Scott, H. L. (2003)

Presynaptic Glutamate Transport in the Brain

Borisova, Т. (2013) · SpringerBriefs in neuroscience · doi:10.1007/978-1-4614-7759-4_1

Amyotrophic Lateral Sclerosis and Glutamate — Too Much of a Good Thing?

Choi, D. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262210 · Cited by 30

Glutamate transporters: Gene expression regulation and signaling properties

Olivares-Bañuelos, T. N., Chi-Castañeda, D., & Ortega, A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.032 · Cited by 33