Glutamate Transporters in Neurologic Disease

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

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Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

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El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

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Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

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Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

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ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

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Primary structure and functional characterization of a high-affinity glutamate transporter

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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Cloning and expression of a rat brain L-glutamate transporter

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Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

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Kindling and status epilepticus models of epilepsy: rewiring the brain

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Astrocyte dysfunction in neurological disorders: a molecular perspective

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Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

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Tau and tauopathies

Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism

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Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

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The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

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Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies

Farina, M., da Rocha, J. B. T., & Aschner, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.019 · Cited by 472

Huntington's disease: from pathology and genetics to potential therapies

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

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Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

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Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH

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Stress as a neuroinflammatory condition in brain: Damaging and protective mechanisms

García‐Bueno, B., Caso, J. R., & Leza, J. C. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.001 · Cited by 291

Glial Cells and Neurotransmission

Auld, D. S., & Robitaille, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00607-x · Cited by 239

Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets

Rico, E. P., Rosemberg, D. B., Seibt, K. J., Capiotti, K. M., Silva, R. S. D., & Bonan, C. D. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.07.007 · Cited by 237

Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

Graves, M. C., Fiala, M., Dinglasan, L. A. V., Liu, N., Sayre, J. W., Chiappelli, F., van Kooten, C., & Vinters, H. V. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820410020286 · Cited by 211

Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures

Frizzo, M. E., Dall’Onder, L. P., Dalcin, K. B., & Souza, D. O. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012717.37839.07 · Cited by 213

Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120

Wang, Z., Pekarskaya, O., Bencheikh, M., Chao, W., Gelbard, H. A., Ghorpade, A., Rothstein, J. D., & Volsky, D. J. (2003) · Virology · doi:10.1016/s0042-6822(03)00181-8 · Cited by 212

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Neymotin, A., Calingasan, N. Y., Wille, E. J., Naseri, N., Petri, S., Damiano, M. G., Liby, K. T., Risingsong, R., Sporn, M. B., Beal, M. F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.027 · Cited by 212

Glutamate–glutamine Cycling in the Epileptic Human Hippocampus

Petroff, O. A. C., Errante, L. D., Rothman, D. L., Kim, J., & Spencer, D. D. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.38901.x · Cited by 206

Drug repositioning and repurposing for Alzheimer disease

Ballard, C., Aarsland, D., Cummings, J., O’Brien, J., Mills, R., Molinuevo, J. L., Fladby, T., Williams, G., Doherty, P., Corbett, A., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0397-4 · Cited by 201

Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS

von Lewinski, F., & Keller, B. U. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.001 · Cited by 186

Microelectrode array studies of basal and potassium‐evoked release of l ‐glutamate in the anesthetized rat brain

Day, B. K., Pomerleau, F., Burmeister, J. J., Huettl, P. F., & Gerhardt, G. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03673.x · Cited by 174

Selective defect of in vivo glycolysis in early Huntington's disease striatum

Powers, W. J., Videen, T. O., Markham, J., McGee‐Minnich, L., Antenor‐Dorsey, J. A. V., Hershey, T. G., & Perlmutter, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609833104 · Cited by 174

Molecular targets in the treatment of anxiety

KENT, J. M., Mathew, S. J., & Gorman, J. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01672-4 · Cited by 168

Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: A decade of advance

Cherlyn, S. Y. T., Woon, P. S., Liu, J., Ong, W., Tsai, G., & Sim, K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.002 · Cited by 165

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

Martin, K. R. G., Levkovitch-Verbin, H., Valenta, D. F., Baumrind, L. A., Pease, M. E., & Quigley, H. A. (2002) · PubMed · Cited by 161

Cortical selective vulnerability in motor neuron disease: a morphometric study

Maekawa, S., Al‐Sarraj, S., Kibble, M., Landau, S., Parnavelas, J. G., Cotter, D., Everall, I., & Leigh, P. N. (2004) · Brain · doi:10.1093/brain/awh132 · Cited by 160

Glia in the pathogenesis of neurodegenerative diseases

Verkhratsky, A., Parpura, V., Pekna, M., Pekny, M., & Sofroniew, M. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140107 · Cited by 141

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Divakaruni, A. S., Wallace, M., Buren, C., Martyniuk, K. M., Andreyev, A. Y., Li, E., Fields, J. A., Cordes, T., Reynolds, I. J., Bloodgood, B. L., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612067 · Cited by 169

Synaptically induced sodium signals in hippocampal astrocytes in situ

Langer, J., & Rose, C. R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.182279 · Cited by 155

Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury

van Landeghem, F. K. H., Weiss, T., Oehmichen, M., & von Deimling, A. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1518 · Cited by 151

Increased Expression of the Neuronal Glutamate Transporter (EAAT3/EAAC1) in Hippocampal and Neocortical Epilepsy

Crino, P. B., Jin, H., Shumate, M. D., Robinson, M. B., Coulter, D. A., & Brooks‐Kayal, A. R. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.35001.x · Cited by 148

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

Hurtado, O., Moro, M. Á., Cárdenas, A., Sánchez, V., Fernández-Tomé, P., Leza, J. C., Lorenzo, P. L., Secades, J. J., Lozano, R., Dávalos, A., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.006 · Cited by 147

Altered expression of the glutamate transporter EAAT2b in neurological disease

Maragakis, N. J., Dykes‐Hoberg, M., & Rothstein, J. D. (2004) · Annals of Neurology · doi:10.1002/ana.20003 · Cited by 138

Rapid Trafficking of the Neuronal Glutamate Transporter, EAAC1

Fournier, K. M., González, M. I., & Robinson, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404032200 · Cited by 137

Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

Cárdenas‐Rodríguez, N., Huerta-Gertrudis, B., Rivera-Espinosa, L., Montesinos-Correa, H., Bandala, C., Carmona‐Aparicio, L., & Coballase-Urrutía, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011455 · Cited by 139

Ischemic Preconditioning Reveals that GLT1/EAAT2 Glutamate Transporter is a Novel PPARγ Target Gene Involved in Neuroprotection

Romera, C., Hurtado, O., Mallolas, J., Pereira, M. P., Morales, J. R., Romera, A., Serena, J. L., Vivancos, J., Nombela, F., Lorenzo, P. L., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600438 · Cited by 135

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

Bae, J. S., Simon, N. G., Menon, P., Vucic, S., & Kiernan, M. C. (2013) · Journal of Clinical Neurology · doi:10.3988/jcn.2013.9.2.65 · Cited by 143

Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes

Dabir, D. V., Robinson, M. B., Swanson, E., Zhang, B., Trojanowski, J. Q., Lee, V. M. ‐., & Forman, M. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3861-05.2006 · Cited by 138

In VitroIschemic Tolerance Involves Upregulation of Glutamate Transport Partly Mediated by the TACE/ADAM17-Tumor Necrosis Factor-α Pathway

Romera, C., Hurtado, O., Botella, S. H., Lizasoaín, I., Cárdenas, A., Fernández-Tomé, P., Leza, J. C., Lorenzo, P. L., & Moro, M. Á. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1596-03.2004 · Cited by 128

Protective autoimmunity against the enemy within: fighting glutamate toxicity

Schwartz, M. H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00126-7 · Cited by 128

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Malta, C. D., Fryer, J. D., Settembre, C., & Ballabio, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209577109 · Cited by 123

Patho-physiological and toxicological aspects of monosodium glutamate

Chakraborty, S. P. (2018) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2018.1528649 · Cited by 114

The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective

Mossink, B., Negwer, M., Schubert, D., & Nadif Kasri, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03714-5 · Cited by 114

Glial Tau Pathology in Tauopathies: Functional Consequences

Kahlson, M. A., & Colodner, K. J. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s25515 · Cited by 119

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

Le, H., Sin, W. C., Lozinsky, S., Bechberger, J. F., Vega, J. L., Guo, X., Sáez, J. C., & Naus, C. C. G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508390 · Cited by 111

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

Jaiswal, M. K., Zech, W., Goos, M., Leutbecher, C., Ferri, A., Zippelius, A., Carrı̀, M. T., Nau, R., & Keller, B. U. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-64 · Cited by 111

Ferrostatin-1 protects HT-22 cells from oxidative toxicity

Li, Q., Chu, J., Liu, C.-X., & Song, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266060 · Cited by 108

Research Applications of Magnetic Resonance Spectroscopy to Investigate Psychiatric Disorders

Dager, S. R., Corrigan, N. M., Richards, T. L., & Posse, S. (2008) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e318181e0be · Cited by 109

Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional huntington’s disease mouse model

Wood, T. E., Barry, J., Yang, Z., Cepeda, C., Levine, M. S., & Gray, M. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy363 · Cited by 104

Multiple pathways contribute to the pathogenesis of Huntington disease.

Li, S., & Li, X. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-19 · Cited by 111

Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 111

The endocannabinoid pathway in Huntington's disease: A comparison with other neurodegenerative diseases

Maccarrone, M., Battista, N., & Centonze, D. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.006 · Cited by 109

Evidence of alterations in brain structure and antioxidant status following ‘low-dose’ monosodium glutamate ingestion

Onaolapo, O. J., Onaolapo, A. Y., Akanmu, M. A., & Olayiwola, G. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.05.001 · Cited by 104

Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity

Liang, J., Takeuchi, H., Doi, Y., Kawanokuchi, J., Sonobe, Y., Jin, S., Yawata, I., Li, H., Yasuoka, S., Mizuno, T., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.012 · Cited by 99

Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia

Meador‐Woodruff, J. H., Clinton, S. M., Beneyto, M., & McCullumsmith, R. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.005 · Cited by 104

Molecular and cellular physiology of sodium-dependent glutamate transporters

Rose, C. R., Ziemens, D., Untiet, V., & Fahlke, C. M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.12.013 · Cited by 100

Role of astrocytes in manganese mediated neurotoxicity

Sidoryk‐Wȩgrzynowicz, M., & Aschner, M. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-23 · Cited by 98

Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection

Ganel, R., Ho, T. W., Maragakis, N. J., Jackson, M. T., Steiner, J. P., & Rothstein, J. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.014 · Cited by 98

Cortical cultures coupled to Micro-Electrode Arrays: A novel approach to perform in vitro excitotoxicity testing

Frega, M., Pasquale, V., Tedesco, M., Marcoli, M., Contestabile, A., Nanni, M., Bonzano, L., Maura, G., & Chiappalone, M. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.08.001 · Cited by 93

Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration

Andrés‐Benito, P., Moreno, J. R., Aso, E., Povedano, M., & Ferrer, I. (2017) · Aging · doi:10.18632/aging.101195 · Cited by 92

Behavioral and neurochemical effects of proline

Wyse, Â. T. D. S., & Netto, C. A. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9246-x · Cited by 93

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Wilson, H., Dervenoulas, G., Pagano, G., Tyacke, R. J., Polychronis, S., Myers, J., Gunn, R. N., Rabiner, E. A., Nutt, D., & Politis, M. (2019) · Brain · doi:10.1093/brain/awz260 · Cited by 94

Glutaminase in microglia: A novel regulator of neuroinflammation

Ding, L., Xu, X., Li, C., Wang, Y., Xia, X., & Zheng, J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.038 · Cited by 91

Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice

Farina, M. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00242-x · Cited by 90

Methylmercury Increases Glutamate Release from Brain Synaptosomes and Glutamate Uptake by Cortical Slices from Suckling Rat Pups: Modulatory Effect of Ebselen

Farina, M. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg058 · Cited by 89

Glutamate transporter expression and function in human glial progenitors

Maragakis, N. J., Dietrich, J., Wong, V., Xue, H., Mayer‐Pröschel, M., Rao, M. S., & Rothstein, J. D. (2003) · Glia · doi:10.1002/glia.10310 · Cited by 87

Neuronal and glial metabolite content of the epileptogenic human hippocampus

Petroff, O. A. C., Errante, L. D., Rothman, D. L., Kim, J., & Spencer, D. D. (2002) · Annals of Neurology · doi:10.1002/ana.10360 · Cited by 87

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Roman, J. Y. M., & González, C. C. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.46 · Cited by 90

Neuron-Glia Interactions as Therapeutic Targets in Neurodegeneration

Salmina, A. B. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0988 · Cited by 88

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

Gupta, K., Hardingham, G. E., & Chandran, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.010 · Cited by 85

Necroptosis contributes to the NMDA-induced excitotoxicity in rat’s cultured cortical neurons

Li, Y., Yang, X., Ma, C., Qiao, J., & Zhang, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.037 · Cited by 82

Premature death of TDP ‐43 ( A 315 T ) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis

Esmaeili, M. A., Panahi, M., Yadav, S., Hennings, L. J., & Kiaei, M. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12006 · Cited by 87

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration

Arnold, F. J., Putka, A. F., Raychaudhuri, U., Hsu, S., Bedlack, R., Bennett, C. L., & Spada, A. R. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115587 · Cited by 101

Neurobiological evidence for thalamic, hippocampal and related glutamatergic abnormalities in bipolar disorder: A review and synthesis

Ng, W. X. D., Lau, I. Y., Graham, S., & Sim, K. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.001 · Cited by 85

Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease

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An Insight into Cellular and Molecular Mechanisms Underlying the Pathogenesis of Neurodegeneration in Alzheimer’s Disease

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