The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Low Blood Pressure and Risk of Dementia in the Kungsholmen Project: A 6-Year Follow-up Study
Abstract
BACKGROUND: Previous studies have reported a higher prevalence of dementia in persons with low blood pressure. OBJECTIVE: To examine whether low blood pressure is prospectively associated with the occurrence of Alzheimer disease and dementia in elderly people. SUBJECTS AND METHODS: A community-based, dementia-free cohort (n = 1270) aged 75 to 101 years was longitudinally examined twice within 6 years to detect incident dementia using the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteria. Cox proportional hazards models were used to analyze blood pressure in association with dementia after adjustment for several potential confounders. RESULTS: During the 6-year period, 339 subjects were diagnosed with dementia, including 256 persons with Alzheimer disease. Subjects with very high systolic pressure (>180 vs 141-180 mm Hg) had an adjusted relative risk of 1.5 (95% confidence interval [CI], 1.0-2.3; P =.07) for Alzheimer disease, and 1.6 (95% CI, 1.1-2.2) for dementia. Low systolic pressure (</=140 mm Hg) was not related to incident dementia. In contrast, high diastolic pressure (>90 mm Hg) was not associated with dementia incidence, whereas extremely low diastolic pressure (</=65 vs 66-90 mm Hg) produced an adjusted relative risk of 1.7 (95% CI, 1.1-2.4) for Alzheimer disease and 1.5 (95% CI, 1.0-2.1; P =.03) for dementia. The latter association was pronounced particularly in persons who used antihypertensive drugs. CONCLUSIONS: Both low diastolic and high systolic pressure are associated with an increased risk of Alzheimer disease and dementia in this elderly population. The atherosclerotic process may explain the observed associations. In addition, low diastolic pressure may increase dementia risk by affecting cerebral perfusion.
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Cites
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Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study
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“The pathophysiological implications of blood pressure levels are largely age-dependent.(33,37) Our findings may therefore not totally apply to younger age groups.”
Background15-year longitudinal study of blood pressure and dementia
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Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
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Influence of social network on occurrence of dementia: a community-based longitudinal study
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Self-citation(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338
Association Between Arterial Stiffness and Atherosclerosis: The Rotterdam Study
van Popele, N. M., Grobbee, D. E., Bots, M. L., Asmar, R., Topouchian, J., Reneman, R. S., Hoeks, A. P. G., van der Kuip, D. A. M., Hofman, A., & Witteman, J. C. M. (2001) · Stroke · doi:10.1161/01.str.32.2.454 · Cited by 1,142
Cited by
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261
Self-citationThe age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138
Self-citationIntegrative regulation of human brain blood flow
Willie, C. K., Tzeng, Y., Fisher, J. A., & Ainslie, P. N. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.268953 · Cited by 872
Mitchell, G. F. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90549.2008 · Cited by 764
Metadata
- Authors
- Qiu, C., von Strauss, E., Fastbom, J., Winblad, B., & Fratiglioni, L.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2003-02-01
- Volume
- 60
- Issue
- 2
- Pages
- 223
- ISSN
- 0003-9942
- OpenAlex
- W2001299015
- Cited by
- 291
- References
- 37
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Qiu, C., von Strauss, E., Fastbom, J., Winblad, B., & Fratiglioni, L. (2003). Low Blood Pressure and Risk of Dementia in the Kungsholmen Project: A 6-Year Follow-up Study. Archives of Neurology. https://doi.org/10.1001/archneur.60.2.223
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