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Cited by 1,142Cardiovascular Health and Disease PreventionElasticity and Material ModelingPeripheral Artery Disease Management

Association Between Arterial Stiffness and Atherosclerosis: The Rotterdam Study

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van Popele, Nicole M., Grobbee, Diederick E., Bots, Michiel L., Asmar, Roland, Topouchian, Jirar, Reneman, Robert S., Hoeks, Arnold P. G., van der Kuip, Deidre A. M. +2 more·2001·Stroke
DOI 10.1161/01.str.32.2.454
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Abstract

Background and Purpose —Studies of the association between arterial stiffness and atherosclerosis are contradictory. We studied stiffness of the aorta and the common carotid artery in relation to several indicators of atherosclerosis. Methods —This study was conducted within the Rotterdam Study in >3000 elderly subjects aged 60 to 101 years. Aortic stiffness was assessed by measuring carotid-femoral pulse wave velocity, and common carotid artery stiffness was assessed by measuring common carotid distensibility. Atherosclerosis was assessed by common carotid intima-media thickness, plaques in the carotid artery and in the aorta, and the presence of peripheral arterial disease. Data were analyzed by ANCOVA with adjustment for age, sex, mean arterial pressure, and heart rate. Results —Both aortic and common carotid artery stiffness were found to have a strong positive association with common carotid intima-media thickness, severity of plaques in the carotid artery, and severity of plaques in the aorta ( P for trend <0.01 for all associations). Subjects with peripheral arterial disease had significantly increased aortic stiffness ( P =0.001) and borderline significantly increased common carotid artery stiffness ( P =0.08) compared with subjects without peripheral arterial disease. Results were similar after additional adjustment for cardiovascular risk factors and after exclusion of subjects with prevalent cardiovascular disease. Conclusions —This population-based study shows that arterial stiffness is strongly associated with atherosclerosis at various sites in the vascular tree.

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Crossref · 10.1161/01.str.32.2.454

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  • Increased arterial stiffness leads to overestimation of systolic, diastolic and mean arterial BPs when using fixed-ratio coefficients.

    “In particular, increased arterial stiffness leads to overestimation of systolic, diastolic and mean arterial BPs [60, 62–64].”

    From Automated 'oscillometric' blood pressure measuring devices: how they work and what they measure (2022) · cites this paper as [63]

    The Arterial Stiffness methods section describes measuring blood pressure and calculating mean arterial pressure with a one-third pulse-pressure coefficient, but does not assess whether that calculation overestimates pressure. The Discussion says stiffness increases systolic and decreases diastolic blood pressure; it does not address overestimation of measured systolic, diastolic, or mean arterial pressure. (LLM, conf=0.76)

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Research works printed but not linked: 2

  1. [3]3. Lehmann ED. Elastic properties of the aorta. Lancet. 1993;342:1417.
  2. [20]20. Bots ML, van Meurs JCHM, Grobbee DE. Assessment of atherosclerosis: a new perspective. J Drug Res. 1991;16:150 -154.

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Authors
van Popele, N. M., Grobbee, D. E., Bots, M. L., Asmar, R., Topouchian, J., Reneman, R. S., Hoeks, A. P. G., van der Kuip, D. A. M., Hofman, A., & Witteman, J. C. M.
Affiliations
  • From the Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam (Netherlands) (N.M. van P., D.E.G., M.L.B., D.A.M. van der K., A.H., J.C.M.W.); Julius Center for Patient Oriented Research, University Medical Center Utrecht (Netherlands) (D.E.G., M.L.B.); Cardiovascular Institute, Paris, France (R.A., J.T.); and Departments of Physiology (R.S.R.) and Biophysics (A.P.G.H.), Cardiovascular Research Institute Maastricht, Maastricht University (Netherlands).
  • Erasmus MC (NL)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-02
Volume
32
Issue
2
Pages
454-460
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.32.2.454
OpenAlex
W2096237016
Semantic Scholar
14d6bcc8030a31a310820e85144820fcc209a76b
Cited by
1,142
References
38
Citations by year
2026: 21 · 2025: 19 · 2024: 28 · 2023: 26 · 2022: 41 · 2021: 42 · 2020: 42 · 2019: 36 · 2018: 48 · 2017: 50 · 2016: 63 · 2015: 68 · 2014: 62 · 2013: 60 · 2012: 56
FWCI
28.49
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Keywords
arterial stiffness, atherosclerosis, aortic stiffness, carotid artery stiffness, pulse wave velocity, carotid-femoral pulse wave velocity, carotid intima-media thickness, carotid plaque, aortic plaque, peripheral arterial disease, older adults, cardiovascular risk factors
MeSH terms
Aged, Aged, 80 and over, Aortic Diseases, Aortography, Arteriosclerosis, Blood Pressure, Carotid Artery Diseases, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Netherlands, Posture, Predictive Value of Tests, Pulsatile Flow, Risk Factors, Ultrasonography, Reproducibility of Results, Cohort Studies, Comorbidity, Linear Models, Carotid Artery, Common, Age Distribution, Sex Distribution

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