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Cited by 592Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Relation of Diabetes to Mild Cognitive Impairment

Luchsinger, José A., Reitz, Christiane, Patel, Bindu, Tang, Ming-Xin, Manly, Jennifer J., Mayeux, Richard·2007·Archives of Neurology
DOI 10.1001/archneur.64.4.570
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Abstract

BACKGROUND: Type 2 diabetes mellitus is an important risk factor for Alzheimer disease and is more prevalent in elderly minority persons compared with non-Hispanic white persons. OBJECTIVE: To determine whether diabetes is related to a higher risk of mild cognitive impairment (MCI), a transitional stage between normal cognition and Alzheimer disease, in a multiethnic cohort with a high prevalence of diabetes. DESIGN: Longitudinal cohort study. SETTING: Northern Manhattan in New York, NY. PARTICIPANTS: We studied persons without prevalent MCI or dementia at baseline and with at least 1 follow-up interval. Of 1772 participants with a complete neuropsychological evaluation, 339 (19.1%) were excluded because of prevalent dementia, 304 were excluded because of prevalent MCI (17.2%), and 211 were excluded because of loss to follow-up (11.9%), resulting in a final sample of 918 participants for longitudinal analyses. MAIN OUTCOME MEASURES: We related diabetes defined by self-report to incident all-cause MCI, amnestic MCI, and nonamnestic MCI. We conducted multivariate analyses with proportional hazards regression adjusting for age, sex, years of education, ethnic group, apolipoprotein E (APOE) epsilon4 allele, hypertension, low-density lipoprotein level, current smoking, heart disease, and stroke. RESULTS: A total of 334 persons had incident MCI, 160 (47.9%) had amnestic MCI, and 174 (52.1%) had nonamnestic MCI. Diabetes was related to a significantly higher risk of all-cause MCI and amnestic MCI after adjustment for all covariates. Diabetes was also related to a higher risk of nonamnestic MCI, but this association was appreciably attenuated after adjustment for socioeconomic variables and vascular risk factors. The risk of MCI attributable to diabetes was 8.8% for the whole sample and was higher for African American persons (8.4%) and Hispanic persons (11.0%) compared with non-Hispanic white persons (4.6%), reflecting the higher prevalence of diabetes in minority populations in the United States. CONCLUSION: Diabetes is related to a higher risk of amnestic MCI in a population with a high prevalence of this disorder.

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Metadata

Authors
Luchsinger, J. A., Reitz, C., Patel, B., Tang, M.-X., Manly, J. J., & Mayeux, R.
ORCID
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
2007-04-01
Volume
64
Issue
4
Pages
570
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.64.4.570
OpenAlex
W2034664059
Cited by
592
References
58
Citations by year
2026: 14 · 2025: 22 · 2024: 24 · 2023: 26 · 2022: 24 · 2021: 28 · 2020: 37 · 2019: 32 · 2018: 28 · 2017: 29 · 2016: 35 · 2015: 33 · 2014: 47 · 2013: 34 · 2012: 39
FWCI
19.93
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P01AG007232, K08AG020856, AG 07702, AG 07232, 1K08 AG 20856-01)
  • National Center for Research Resources (RR 00645, M01RR000645)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
type 2 diabetes, mild cognitive impairment, amnestic mild cognitive impairment, non-amnestic mild cognitive impairment, Alzheimer's disease risk, racial and ethnic disparities, African Americans, Hispanic Americans, minority groups, vascular risk factors, socioeconomic factors
MeSH terms
Aged, Aged, 80 and over, Analysis of Variance, Apolipoproteins E, Black or African American, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Neuropsychological Tests, New York, Risk Factors, Cohort Studies, Prevalence, White People

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