Cited by 7,864Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

Mild cognitive impairment as a diagnostic entity

Open access
Petersen, R. C.·2004·Journal of Internal Medicine

Abstract

The concept of cognitive impairment intervening between normal ageing and very early dementia has been in the literature for many years. Recently, the construct of mild cognitive impairment (MCI) has been proposed to designate an early, but abnormal, state of cognitive impairment. MCI has generated a great deal of research from both clinical and research perspectives. Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) in MCI subjects and certain predictor variables appear valid. However, there has been controversy regarding the precise definition of the concept and its implementation in various clinical settings. Clinical subtypes of MCI have been proposed to broaden the concept and include prodromal forms of a variety of dementias. It is suggested that the diagnosis of MCI can be made in a fashion similar to the clinical diagnoses of dementia and AD. An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations.

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Crossref · 10.1111/j.1365-2796.2004.01388.x

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Authors
Petersen, R. C.
Affiliations
Mayo Clinic (US)
Corresponding author
Petersen, R. C.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2004-08-20
Volume
256
Issue
3
Pages
183-194
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2028436804
Cited by
7,864
References
8
Citations by year
2026: 344 · 2025: 493 · 2024: 478 · 2023: 440 · 2022: 475 · 2021: 535 · 2020: 499 · 2019: 479 · 2018: 433 · 2017: 428 · 2016: 385 · 2015: 402 · 2014: 395 · 2013: 391 · 2012: 367
FWCI
13.63
Type
journal article
Language
en
Open access
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 10483, AG-06786, AG 16574, U01AG006786, P50AG016574)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
mild cognitive impairment, dementia, Alzheimer's disease, prodromal dementia, MCI classification, diagnostic criteria, conversion to dementia, cognitive aging
MeSH terms
Aged, Alzheimer Disease, Cognition Disorders, Humans, Neuropsychological Tests, Terminology as Topic, Psychiatric Status Rating Scales

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