Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
Abstract
BACKGROUND: We used a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). OBJECTIVE: To assess CSF BACE1 activity in AD. DESIGN: Case-control and longitudinal follow-up study. SETTING: Specialized memory clinic. Patients Eighty-seven subjects with AD, 33 cognitively normal control subjects, and 113 subjects with mild cognitive impairment (MCI), who were followed up for 3 to 6 years. MAIN OUTCOME MEASURES: Cerebrospinal fluid BACE1 activity in relation to diagnosis and CSF levels of secreted APP and amyloid beta protein (Abeta) isoforms and the axonal degeneration marker total tau. RESULTS: Subjects with AD had higher CSF BACE1 activity (median, 30 pM [range, 11-96 pM]) than controls (median, 23 pM [range, 8-43 pM]) (P =.02). Subjects with MCI who progressed to AD during the follow-up period had higher baseline BACE1 activity (median, 35 pM [range, 18-71 pM]) than subjects with MCI who remained stable (median, 29 pM [range, 14-83 pM]) (P < .001) and subjects with MCI who developed other forms of dementia (median, 20 pM [range, 10-56 pM]) (P <.001). BACE1 activity correlated positively with CSF levels of secreted APP isoforms and Abeta(40) in the AD and control groups and in all MCI subgroups (P < .05) except the MCI subgroup that developed AD. Strong positive correlations were found between CSF BACE1 activity and total tau levels in all MCI subgroups (r >or= 0.57, P
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CSF BACE1 concentration and activity have good diagnostic performance in discriminating AD dementia, MCI, and cognitively healthy individuals.
“During the past 15 years, a few human in vivo studies reported good diagnostic performance of CSF BACE1 concentration (supposed to reflect gene expression levels) and activity in discriminating among patients with AD dementia, patients with MCI, and cognitively healthy individuals (79–85).”
From The β-Secretase BACE1 in Alzheimer’s Disease (2021) · cites this paper as [83]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K., & Minthon, L. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70355-6 · Cited by 1,700 · see citing works
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246 · see citing works
Roberds, S. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1317 · Cited by 705 · see citing works
β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease
Fukumoto, H. (2002) · Archives of Neurology · doi:10.1001/archneur.59.9.1381 · Cited by 694 · see citing works
CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
Strozyk, D., Blennow, K., White, L. R., & Launer, L. J. (2003) · Neurology · doi:10.1212/01.wnl.0000046581.81650.d0 · Cited by 604 · see citing works
Cerebrospinal fluid protein biomarkers for Alzheimer’s disease
Blennow, K. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.2.213 · Cited by 487 · see citing works
Report of the second dementia with Lewy body international workshop
McKeith, I. G., Perry, E. K., & Perry, R. H. (1999) · Neurology · doi:10.1212/wnl.53.5.902 · Cited by 464 · see citing works
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
Dominguez, D. I., Tournoy, J., Hartmann, D., Huth, T., Cryns, K., Deforce, S., Serneels, L., Espuny-Camacho, I., Marjaux, E., Craessaerts, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505249200 · Cited by 359 · see citing works
Zhong, Z., Ewers, M., Teipel, S., Bürger, K., Wallin, A., Blennow, K., He, P., McAllister, C., Hampel, H., & Shen, Y. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.718 · Cited by 206 · see citing works
Bourne, K. Z., Ferrari, D. C., Lange‐Dohna, C., Roßner, S., Wood, T. G., & Perez-Polo, J. R. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21252 · Cited by 188 · see citing works
Kanekiyo, T., Ban, T., Aritake, K., Huang, Z., Qu, W., Okazaki, I., Mohri, I., Murayama, S., Ozono, K., Taniike, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701585104 · Cited by 147 · see citing works
Ewers, M., Zhong, Z., Bürger, K., Wallin, A., Blennow, K., Teipel, S. J., Shen, Y., & Hampel, H. (2008) · Brain · doi:10.1093/brain/awn034 · Cited by 119 · see citing works
Increased β‐Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects
Holsinger, R. M. D., McLean, C., Collins, S. J., Masters, C. L., & Evin, G. M. (2004) · Annals of Neurology · doi:10.1002/ana.20144 · Cited by 96 · see citing works
CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias
Holsinger, R. M. D., Lee, J. S., Boyd, A., Masters, C. L., & Collins, S. J. (2006) · Neurology · doi:10.1212/01.wnl.0000229925.52203.4c · Cited by 77 · see citing works
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Johnston, J. A., Liu, W. W., Todd, S., Coulson, D. T. R., Murphy, S., Irvine, G. B., & Passmore, A. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051096 · Cited by 76 · see citing works
Aspects of β-Amyloid as a Biomarker for Alzheimer's Disease
Andréasson, U., Portelius, E., Andersson, M. E., Blennow, K., & Zetterberg, H. (2007) · Biomarkers in Medicine · doi:10.2217/17520363.1.1.59 · Cited by 74 · see citing works
Detection of a Soluble Form of BACE-1 in Human Cerebrospinal Fluid by a Sensitive Activity Assay
Verheijen, J. H., Huisman, L. G. M., van Lent, N., Neumann, U., Paganetti, P., Hack, C. E., Bouwman, F. H., Lindeman, J. H. N., Bollen, E. L. E. M., & Hanemaaijer, R. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.066720 · Cited by 67 · see citing works
Shi, X.-P., Tugusheva, K., Bruce, J. E., Lucka, A., Chen-Dodson, E., Hu, B., Wu, G.-X., Price, E. A., Register, R. B., Lineberger, J. E., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7207 · Cited by 36 · see citing works
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Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.4 · Cited by 1,863 · see citing works
Self-citationThe β-Secretase BACE1 in Alzheimer’s Disease
Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.001 · Cited by 694 · see citing works
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
Hampel, H. J., Frank, R., Broich, K., Teipel, S. J., Katz, R. G., Hardy, J., Herholz, K., Bokde, A. L. W., Jessen, F., Hoessler, Y. C., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3115 · Cited by 630 · see citing works
A Phase II Trial of Tideglusib in Alzheimer's Disease
Lovestone, S., for the ARGO investigators, Boada, M., Dubois, B., Hüll, M., Rinne, J. O., Huppertz, H.-J., Calero, M., Andrés, M. V., Gómez-Carrillo, B., et al. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141959 · Cited by 536 · see citing works
Current state of Alzheimer’s fluid biomarkers
Molinuevo, J. L., Ayton, S., Batrla, R., Bednar, M. M., Bittner, T., Cummings, J., Fagan, A. M., Hampel, H., Mielke, M. M., Mikulskis, A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1932-x · Cited by 518 · see citing works
Amyloid biomarkers in Alzheimer's disease
Blennow, K., Mattsson, N., Schöll, M., Hansson, O., & Zetterberg, H. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.002 · Cited by 470 · see citing works
Salomone, S., Caraci, F., Leggio, G. M., Fedotova, J., & Drago, F. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04134.x · Cited by 322 · see citing works
Liu, C., Song, J., Zhang, Y., & Wang, P. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2484 · Cited by 221 · see citing works
Fluid biomarkers in Alzheimer’s disease – current concepts
Rosén, C., Hansson, O., Blennow, K., & Zetterberg, H. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-20 · Cited by 214 · see citing works
Fluid Biomarkers in Alzheimer Disease
Blennow, K., Zetterberg, H., & Fagan, A. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006221 · Cited by 208 · see citing works
Idiopathic normal-pressure hydrocephalus
Jeppsson, A., Zetterberg, H., Blennow, K., & Wikkelsø, C. (2013) · Neurology · doi:10.1212/wnl.0b013e31828c2fda · Cited by 183 · see citing works
Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
Paris, D., Ganey, N. J., Laporte, V., Patel, N. S., Beaulieu‐Abdelahad, D., Bachmeier, C. J., March, A., Ait‐Ghezala, G., & MULLAN, M. J. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-17 · Cited by 169 · see citing works
A novel pathway for amyloid precursor protein processing
Portelius, E., Price, E. A., Brinkmalm, G., Stiteler, M., Olsson, M., Persson, R., Brinkmalm, A., Zetterberg, H., Simon, A. J., & Blennow, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.002 · Cited by 169 · see citing works
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease
Alcolea, D., Martínez-Lage, P., Sánchez-Juan, P., Olazarán, J., Antúnez, C., Izagirre, A., Ecay-Torres, M., Estanga, A., Clerigué, M., Guisasola, M. C., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001859 · Cited by 163 · see citing works
BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.
Barão, S., Moechars, D., Lichtenthaler, S., & de Strooper, B. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.003 · Cited by 161 · see citing works
Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 167 · see citing works
Biological markers of amyloid β-related mechanisms in Alzheimer's disease
Hampel, H. J., Shen, Y., Walsh, D. M., Aisen, P. S. S., Shaw, L. M., Zetterberg, H., Trojanowski, J. Q., & Blennow, K. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.024 · Cited by 159 · see citing works
Biomarkers for Alzheimer’s Disease Early Diagnosis
Ausó, E., Gómez‐Vicente, V., & Esquiva, G. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030114 · Cited by 149 · see citing works
Pathak, N., Vimal, S. K., Tandon, I., Agrawal, L., Cao, H., & Bhattacharyya, S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00800-w · Cited by 149 · see citing works
Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
Gisslén, M., Krut, J. J., Andréasson, U., Blennow, K., Cinque, P. M., Brew, B. J., Spudich, S., Hagberg, L., Rosengren, L., Price, R. W., et al. (2009) · BMC Neurology · doi:10.1186/1471-2377-9-63 · Cited by 147 · see citing works
van Rossum, I. A., Vos, S. J. B., Handels, R. L. H., & Visser, P. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091606 · Cited by 143 · see citing works
Trupp, M., Jonsson, P., Öhrfelt, A., Zetterberg, H., Obudulu, O., Malm, L., Wuolikainen, A., Linder, J., Möritz, T., Blennow, K., et al. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-140389 · Cited by 140 · see citing works
Hampel, H. J., Lista, S., & Khachaturian, Z. S. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.2116 · Cited by 138 · see citing works
Shen, Y., Wang, H., Sun, Q., Yao, H., Keegan, A. P., Mullan, M., Wilson, J., Lista, S., Leyhe, T., Laske, C., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.007 · Cited by 123 · see citing works
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
Pera, M., Alcolea, D. A., Sánchez‐Valle, R., Guardia‐Laguarta, C., Colom‐Cadena, M., Badiola, N., Suárez‐Calvet, M., Lladó, A., Barrera-Ocampo, A. A., Falla, D. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1062-9 · Cited by 122 · see citing works
Buchhave, P., Zetterberg, H., Blennow, K., Minthon, L., Janciauskiene, S. M., & Hansson, O. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.012 · Cited by 120 · see citing works
Liu, C., Wang, J., Li, L., Xue, L., Zhang, Y., & Wang, P. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.026 · Cited by 117 · see citing works
Peterson, J. J., Gisslén, M., Zetterberg, H., Fuchs, D., Shacklett, B. L., Hagberg, L., Yiannoutsos, C. T., Spudich, S., & Price, R. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116081 · Cited by 115 · see citing works
Upcoming Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease
Fagan, A. M., & Perrin, R. J. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.42 · Cited by 115 · see citing works
Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus
Pyykkö, O. T., Lumela, M., Rummukainen, J. K., Nerg, O., Seppälä, T. T., Herukka, S., Koivisto, A. M., Alafuzoff, I. I., Puli, L., Savolainen, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091974 · Cited by 114 · see citing works
Amyloid β and APP as biomarkers for Alzheimer’s disease
Zetterberg, H., Blennow, K., & Hanse, E. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.08.002 · Cited by 113 · see citing works
Timmers, M., Streffer, J. R., Russu, A., Tominaga, Y., Shimizu, H., Shiraishi, A., Tatikola, K., Smekens, P., Börjesson-Hanson, A., Andreasen, N., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0415-6 · Cited by 112 · see citing works
Brinkmalm, G., Sjödin, S., Simonsen, A. H., Hasselbalch, S. G., Zetterberg, H., Brinkmalm, A., & Blennow, K. (2018) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201700131 · Cited by 111 · see citing works
Self-citationAnsari, A., Maffioletti, E., Milanesi, E., Marizzoni, M., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Forloni, G., Gennarelli, M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.06.005 · Cited by 111 · see citing works
Jonsson, M. A. G., Zetterberg, H., van Straaten, E. C. W., LIND, K., Syversen, S., Edman, Å., Blennow, K., Rosengren, L., Pantoni, L., Inzitari, D., et al. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02808.x · Cited by 111 · see citing works
Biomarkers in Sporadic and Familial Alzheimer’s Disease
Lista, S., O’Bryant, S. E., Blennow, K., Dubois, B., Hugon, J., Zetterberg, H., & Hampel, H. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-143006 · Cited by 106 · see citing works
Liu, C., Wang, J., Li, L., & Wang, P. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1780 · Cited by 106 · see citing works
The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease
Hillen, H. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01154 · Cited by 106 · see citing works
Biomarker-based dissection of neurodegenerative diseases
Olsson, B., Zetterberg, H., Hampel, H. J., & Blennow, K. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.006 · Cited by 96 · see citing works
CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics
Jeppsson, A., Wikkelsø, C., Blennow, K., Zetterberg, H., Constantinescu, R., Remes, A. M., Herukka, S., Rauramaa, T. H., Nägga, K., Leinonen, V., et al. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-320826 · Cited by 95 · see citing works
Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.
Arbor, S., LaFontaine, M., & Cumbay, M. G. (2016) · Europe PMC (PubMed Central) · Cited by 92 · see citing works
Molecular and Imaging Biomarkers in Alzheimer’s Disease: A Focus on Recent Insights
Villa, C., Lavitrano, M., Salvatore, E., & Combi, R. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030061 · Cited by 89 · see citing works
Regulation of alpha-secretase ADAM10 expression and activity
Endres, K., & Fahrenholz, F. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2885-7 · Cited by 79 · see citing works
Gabelle, A., Roche, S., Gény, C., Bennys, K., Labauge, P. M., Tholance, Y., Quadrio, I., Tiers, L., Gor, B., Chaulet, C., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.022 · Cited by 78 · see citing works
Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease
Milà‐Alomà, M., Suárez‐Calvet, M., & Molinuevo, J. L. (2019) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286419888819 · Cited by 78 · see citing works
Update on Biomarkers For Amyloid Pathology in Alzheimer’s Disease
Ashton, N. J., Schöll, M., Heurling, K., Gkanatsiou, E., Portelius, E., Höglund, K., Brinkmalm, G., Hye, A., Blennow, K., & Zetterberg, H. (2018) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0433 · Cited by 75 · see citing works
Cerebrospinal Fluid Profiles of Amyloid β-Related Biomarkers in Alzheimer’s Disease
Rosén, C., Andréasson, U., Mattsson, N., Marcusson, J. O., Minthon, L., Andreasen, N., Blennow, K., & Zetterberg, H. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8171-4 · Cited by 72 · see citing works
Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease
Prvulovic, D., & Hampel, H. J. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.087 · Cited by 73 · see citing works
Johansson, P., Mattsson, N., Hansson, O., Wallin, A., Johansson, J.-O., Andréasson, U., Zetterberg, H., Blennow, K., & Svensson, J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101878 · Cited by 71 · see citing works
CSF Biomarkers in the Early Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease
Papaliagkas, V. T., Kalinderi, K., Vareltzis, P. K., Μoraitou, D., Papamitsou, T., & Chatzidimitriou, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108976 · Cited by 73 · see citing works
Mattsson, N., Rajendran, L., Zetterberg, H., Gustavsson, M. K., Andréasson, U., Olsson, M., Brinkmalm, G., Lundkvist, J., Jacobson, L. H., Perrot, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031084 · Cited by 70 · see citing works
Wu, G., Sankaranarayanan, S., Wong, J., Tugusheva, K., Michener, M. S., Shi, X., Cook, J. J., Simon, A. J., & Savage, M. J. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23122 · Cited by 68 · see citing works
Increased CSF Levels of Phosphorylated Neurofilament Heavy Protein following Bout in Amateur Boxers
Neselius, S., Zetterberg, H., Blennow, K., Marcusson, J. O., & Brisby, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081249 · Cited by 68 · see citing works
Mattsson, N., Blennow, K., & Zetterberg, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04944.x · Cited by 68 · see citing works
Alzheimer’s disease: biological aspects, therapeutic perspectives and diagnostic tools
Carlo, M. D., Giacomazza, D., & Biagio, P. L. S. (2012) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/24/24/244102 · Cited by 64 · see citing works
Cai, Y., Xiong, K., Zhang, X., Cai, H., Luo, X., Feng, J., Clough, R. W., Struble, R. G., Patrylo, P. R., Chu, Y., et al. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07376.x · Cited by 64 · see citing works
BACE2 Expression Increases in Human Neurodegenerative Disease
Holler, C. J., Webb, R. L., Laux, A. L., Beckett, T. L., Niedowicz, D. M., Ahmed, R. R., Liu, Y., Simmons, C. R., Dowling, A. L. S., Spinelli, A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.034 · Cited by 63 · see citing works
Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
Mattsson, N., Bremell, D., Anckarsäter, R., Blennow, K., Anckarsäter, H. S., Zetterberg, H., & Hagberg, L. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-51 · Cited by 64 · see citing works
Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer’s disease
Ewers, M., Cheng, X., Zhong, Z., Nural, H. F., Walsh, C., Meindl, T., Teipel, S. J., Buerger, K., He, P., Shen, Y., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-091153 · Cited by 58 · see citing works
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease
Cervellati, C., Trentini, A., Rosta, V., Passaro, A., Bosi, C., Sanz, J. M., Bonazzi, S., Pacifico, S., Seripa, D., Valacchi, G., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00127-6 · Cited by 58 · see citing works
Paper-Based Platform with an In Situ Molecularly Imprinted Polymer for β-Amyloid
Pereira, M. V., Marques, A. C., Oliveira, D., Martins, R., Moreira, F. T. C., Sales, M. G. F., & Fortunato, E. M. C. (2020) · ACS Omega · doi:10.1021/acsomega.0c00062 · Cited by 57 · see citing works
Kitazume, S., Yoshihisa, A., Yamaki, T., Oikawa, M., Tachida, Y., Ogawa, K., Imamaki, R., Hagiwara, Y., Kinoshita, N., Takeishi, Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398578 · Cited by 56 · see citing works
Bekris, L. M., Galloway, N. M., Millard, S. P., Lockhart, D., Li, G., Galasko, D. R., Farlow, M. R., Clark, C. M., Quinn, J. F., Kaye, J. A., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.020 · Cited by 52 · see citing works
Systems Approach to Neurodegenerative Disease Biomarker Discovery
Lausted, C. G., Lee, I., Zhou, Y. F., Qin, S., Sung, J., Price, N. D., Hood, L., & Wang, K. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135928 · Cited by 52 · see citing works
Rolstad, S., Jakobsson, J., Sellgren, C. M., Ekman, C. J., Blennow, K., Zetterberg, H., Pålsson, E., & Landén, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127100 · Cited by 52 · see citing works
Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis
Struyfs, H., Niemantsverdriet, E., Goossens, J., Fransén, E., Martin, J., Deyn, P. P. D., & Engelborghs, S. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00138 · Cited by 52 · see citing works
Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
Selnes, P., Blennow, K., Zetterberg, H., Grambaitė, R., Rosengren, L., Johnsen, L., Stenset, V. T. V., & Fladby, T. (2010) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-7-10 · Cited by 52 · see citing works
Vos, A. D., Struyfs, H., Jacobs, D., Fransén, E., Klewansky, T., Roeck, E. E. D., Robberecht, C., Broeckhoven, C. V., Duyckaerts, C. J., Engelborghs, S., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160227 · Cited by 52 · see citing works
Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function
Zhu, K., Peters, F., Filser, S., & Herms, J. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.022 · Cited by 50 · see citing works
Obrocki, P., Khatun, A., Ness, D., Senkevich, K. A., Hanrieder, J., Capraro, F., Mattsson, N., Andréasson, U., Portelius, E., Ashton, N. J., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00586-6 · Cited by 51 · see citing works
Levels of ADAM10 are reduced in Alzheimer’s disease CSF
Sogorb‐Esteve, A., García‐Ayllón, M., Gobom, J., Alom, J., Zetterberg, H., Blennow, K., & Sáez‐Valero, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1255-9 · Cited by 50 · see citing works
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease
Johansson, P., Almqvist, E. G., Johansson, J.-O., Mattsson, N., Hansson, O., Wallin, A., Blennow, K., Zetterberg, H., & Svensson, J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.012 · Cited by 48 · see citing works
Amyloid-related biomarkers and axonal damage proteins in parkinsonian syndromes
Bech, S., Hjermind, L. E., Salvesen, L., Nielsen, J. E., Heegaard, N. H. H., Jørgensen, H. L., Rosengren, L., Blennow, K., Zetterberg, H., & Winge, K. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.08.012 · Cited by 47 · see citing works
Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
Brinkmalm, G., Brinkmalm, A., Bourgeois, P., Persson, R., Hansson, O., Portelius, E., Mercken, M. H., Andréasson, U., Parent, S., Lipari, F., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.019 · Cited by 47 · see citing works
Advanced Overview of Biomarkers and Techniques for Early Diagnosis of Alzheimer’s Disease
Rani, S., Dhar, S. B., Khajuria, A., Gupta, D., Jaiswal, P. K., Singla, N., Kaur, M., Singh, G., & Barnwal, R. P. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01330-y · Cited by 48 · see citing works
Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: The Present and the Future
Ghidoni, R., Benussi, L., Paterlini, A., Albertini, V., Binetti, G. G., & Emanuele, E. (2011) · Neurodegenerative Diseases · doi:10.1159/000327756 · Cited by 44 · see citing works
The effects of different familial Alzheimer’s disease mutations on APP processing in vivo
Þórðardóttir, S., Ståhlbom, A. K., Almkvist, O., Thonberg, H., Eriksdotter, M., Zetterberg, H., Blennow, K., & Graff, C. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0234-1 · Cited by 43 · see citing works
Bram, J. M. D. F., Talib, L. L., Joaquim, H. P. G., Sarno, T. A., Gattaz, W. F., & Forlenza, O. V. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0905-3 · Cited by 43 · see citing works
Hampel, H. J., Lista, S., Vanmechelen, E., Zetterberg, H., Giorgi, F. S., Galgani, A., Blennow, K., Caraci, F., Das, B., Yan, R., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00686-3 · Cited by 42 · see citing works
Early risk assessment for Alzheimer's disease
Carrillo, M. C., Blackwell, A. D., Hampel, H. J., Lindborg, J., Sperling, R. A., Schenk, D., Sevigny, J., Ferris, S. H., Bennett, D. A., Craft, S., et al. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.019 · Cited by 42 · see citing works
Perneczky, R., Alexopoulos, P., & Initiative, A. D. N. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.09.006 · Cited by 41 · see citing works
Zhong, Z., Yuan, K., Tong, X., Hu, J., Song, Z., Zhang, G., Fang, X., & Zhang, W. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001118 · Cited by 41 · see citing works
Lukkarinen, H., Jeppsson, A., Wikkelsø, C., Blennow, K., Zetterberg, H., Constantinescu, R., Remes, A. M., Herukka, S., Hiltunen, M. O., Rauramaa, T. H., et al. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00309-z · Cited by 41 · see citing works
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E. J. M., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150451 · Cited by 38 · see citing works
Early biomarkers for post-stroke cognitive impairment
Qian, L., Ding, L., Cheng, L., Zhu, X., Zhao, H., Jin, J., Guan, D.-N., Zhang, B., Chen, X., & Xu, Y. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6465-y · Cited by 40 · see citing works
Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers
Perneczky, R., Alexopoulos, P., & Kurz, A. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.10.001 · Cited by 40 · see citing works
Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease
Buchhave, P., Janciauskiene, S. M., Zetterberg, H., Blennow, K., Minthon, L., & Hansson, O. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.091 · Cited by 39 · see citing works
CNS Amyloid- , Soluble APP- and - Kinetics during BACE Inhibition
Zakaria, J. A. D., Michener, M. S., Wu, G., Patterson, B. W., Chott, R. C., Ovod, V., Pyatkivskyy, Y., Wildsmith, K. R., Kasten, T. L., Mathers, P. D., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0540-14.2014 · Cited by 39 · see citing works
A new generation of AD biomarkers: 2019 to 2021
Hawksworth, J. I., Fernández, E., & Gevaert, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101654 · Cited by 34 · see citing works
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding
Schauenburg, L., Liebsch, F., Eravci, M., Mayer, M., Weise, C., & Multhaup, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-19530-8 · Cited by 36 · see citing works
White matter changes in familial Alzheimer's disease
Li, X., Westman, E., Ståhlbom, A. K., Thordardottir, S., Almkvist, O., Blennow, K., Wahlund, L., & Graff, C. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12352 · Cited by 34 · see citing works
Processing of the Platelet Amyloid Precursor Protein in the Mild Cognitive Impairment (MCI)
Bermejo‐Bescós, P., Martín‐Aragón, S., Jiménez‐Aliaga, K., Benedı́, J., Felici, E., Gil, P., Ribera, J. M., & Villar, A. M. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1039-7 · Cited by 34 · see citing works
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex
Wu, G., Sankaranarayanan, S., Hsieh, S., Simon, A. J., & Savage, M. J. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22618 · Cited by 34 · see citing works
Şatır, T. M., Agholme, L., Karlsson, A., Karlsson, M., Karila, P., Illes, S., Bergström, P., & Zetterberg, H. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00635-0 · Cited by 33 · see citing works
Cerebrospinal fluid biomarkers in cardiac arrest survivors
Rosén, C., Rosén, H., Andréasson, U., Bremell, D., Bremler, R., Hagberg, L., Rosengren, L., Blennow, K., & Zetterberg, H. (2013) · Resuscitation · doi:10.1016/j.resuscitation.2013.10.032 · Cited by 32 · see citing works
Timmers, M., Barão, S., Broeck, B. V., Tesseur, I. C., Slemmon, J., Waepenaert, K. D., Bogert, J., Shaw, L. M. J., Engelborghs, S., Moechars, D., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160829 · Cited by 32 · see citing works
CSF Presenilin-1 complexes are increased in Alzheimer’s disease
García‐Ayllón, M., Campanari, M., Brinkmalm, G., Rábano, A., Alom, J., Saura, C. A., Andreasen, N., Blennow, K., & Sáez‐Valero, J. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-46 · Cited by 31 · see citing works
Králová, K., Fousková, M., Habartová, L., Fišar, Z., Jirák, R., Raboch, J., & Setnička, V. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.04.002 · Cited by 31 · see citing works
Alexopoulos, P., Tsolakidou, A. F., Roselli, F., Arnold, A., Grimmer, T., Westerteicher, C., Leante, M. R., Förstl, H., Livrea, P., Kurz, A., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.04.009 · Cited by 30 · see citing works
Fluid Biomarkers in Clinical Trials of Alzheimer’s Disease Therapeutics
Ritter, A. R., & Cummings, J. L. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00186 · Cited by 29 · see citing works
- Authors
- Zetterberg, H., Andreasson, U., Hansson, O., Wu, G., Sankaranarayanan, S., Andersson, M. E., Buchhave, P., Londos, E., Umek, R. M., Minthon, L., Simon, A. J., & Blennow, K.
- Affiliations
- University of Gothenburg (SE)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-08-01
- Volume
- 65
- Issue
- 8
- Pages
- 1102-7
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2117635180
- Cited by
- 224
- References
- 23
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 18 · 2017: 7 · 2016: 10 · 2015: 20 · 2014: 15 · 2013: 26 · 2012: 21
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid, Alzheimer's disease, mild cognitive impairment, amyloid precursor protein, amyloid-beta, total tau, axonal degeneration, APP metabolism, biomarkers, disease progression
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Axons, Enzyme Activation, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Nerve Degeneration, Biomarkers, Case-Control Studies, Aspartic Acid Endopeptidases, Amyloid Precursor Protein Secretases
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