Differential Involvement of Optineurin in Amyotrophic Lateral Sclerosis With or Without <emph type="ital">SOD1</emph> Mutations
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BACKGROUND: Mutations in optineurin have recently been linked to amyotrophic lateral sclerosis (ALS). OBJECTIVE: To determine whether optineurin-positive skeinlike inclusions are a common pathologic feature in ALS, including SOD1 -linked ALS. DESIGN: Clinical case series. SETTING: Academic referral center. SUBJECTS: We analyzed spinal cord sections from 46 clinically and pathologically diagnosed ALS cases and ALS transgenic mouse models overexpressing ALS-linked SOD1 mutations G93A or L126Z. RESULTS: We observed optineurin-immunoreactive skeinlike inclusions in all the sporadic ALS and familial ALS cases without SOD1 mutation, but not in cases with SOD1 mutations or in transgenic mice overexpressing the ALS-linked SOD1 mutations G93A or L126Z. CONCLUSION: The data from this study provide evidence that optineurin is involved in the pathogenesis of sporadic ALS and non- SOD1 familial ALS, thus supporting the hypothesis that these forms of ALS share a pathway that is distinct from that of SOD1-linked ALS.
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Mitochondrial abnormalities, together with OPTN-positive inclusions and de novo OPTN mutations found in sALS, are suggestive of attenuated mitophagy.
“Such mitochondrial abnormalities, together with observations of OPTN-positive inclusions and de novo OPTN mutations found in sALS [286–289], are suggestive of attenuated mitophagy.”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [286]
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Barbosa, A. D., Palmer, J. E., Li, X., & Rubinsztein, D. C. (2025) · Learning materials in biosciences · doi:10.1007/978-3-031-88121-3_6
Conditional truncation of the FUS protein in mice : a new animal model of the ALS/FTD continuum
Scekic‐Zahirovic, J. (2016) · theses.fr (ABES) · doi:10.70675/6bed4f95z0a05z438fz937ez33f29f11923d
- Authors
- Deng, H.-X.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Deng, Han-Xiang
- ORCID
- Deng, Han-Xiang
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2011-08-01
- Volume
- 68
- Issue
- 8
- Pages
- 1057
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC3357952
- OpenAlex
- W2107227860
- Cited by
- 67
- References
- 30
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG13854, T32 AG-20506, P30AG013854, T32AG020506)
- National Institute of Neurological Disorders and Stroke (NS050641, R01NS050641)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- optineurin, amyotrophic lateral sclerosis, SOD1 mutations, sporadic ALS, familial ALS, ALS pathogenesis, SOD1 G93A mice, myelopathy
- MeSH terms
- Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Diagnosis, Differential, Eye Proteins, Genetic Markers, Humans, Mice, Transgenic, Neural Pathways, Superoxide Dismutase, Cell Cycle Proteins, Genetic Predisposition to Disease, Membrane Transport Proteins, Transcription Factor TFIIIA, Mice
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