The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Influence of Aging on the Polar and Neutral Lipid Profiles in Human Meibomian Gland Secretions
Open accessAbstract
OBJECTIVE: To determine whether aging is associated with significant alterations in the polar and neutral lipid profiles in human meibomian gland secretions. METHODS: Meibomian gland secretions were collected from both eyes of younger and older men and women. Samples were processed for high-performance liquid chromatography or mass spectrometry and for the analysis of associated spectra of fragment ions. Subjects also underwent slitlamp evaluations of the eyelid. RESULTS: Aging is associated with numerous significant alterations in the lipid profiles of human meibomian gland secretions. Analysis of polar and neutral lipid patterns identified ions that were significantly different in secretions of younger vs older men and women, as well as ions that varied significantly only between men and women. Correlation coefficients within, but not between, groups were high. Aging was accompanied by increased opacity of meibomian gland secretions and by eyelid and eyelid margin changes. CONCLUSION: Aging is associated with significant sex-related alterations in the polar and neutral lipid profiles of human meibomian gland secretions. CLINICAL RELEVANCE: The observed changes may contribute to the age-related increase in the prevalence of dry eye syndromes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Cited by
(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70081-2 · Cited by 3,267
An Objective Approach to Dry Eye Disease Severity
Sullivan, B. D., Whitmer, D., Nichols, K. K., Tomlinson, A., Foulks, G. N., Geerling, G., Pepose, J. S., Kosheleff, V., Porreco, A., & Lemp, M. A. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5390 · Cited by 543
Self-citationGreen-Church, K. B., Butovich, I., Willcox, M., Borchman, D., Paulsen, F., Barabino, S., & Glasgow, B. J. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6997d · Cited by 313
Malhotra, C., Singh, S., Chakma, P., & Jain, A. K. (2015) · Cornea · doi:10.1097/ico.0000000000000446 · Cited by 32
Kovács, I. (2022) · Developments in Health Sciences · doi:10.1556/2066.2021.00047 · Cited by 6
Metadata
- Authors
- Sullivan, B. D.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-09-01
- Volume
- 124
- Issue
- 9
- Pages
- 1286
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2012667683
- Cited by
- 178
- References
- 1
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Influence of Aging on the Polar and Neutral Lipid Profiles in Human Meibomian Gland Secretions. https://app.cochat.ai/papers/10.1001/archopht.124.9.1286
- The paper
- Sullivan, B. D. (2006). Influence of Aging on the Polar and Neutral Lipid Profiles in Human Meibomian Gland Secretions. Archives of Ophthalmology. https://doi.org/10.1001/archopht.124.9.1286
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
