Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging
Abstract
The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3β,17β-diol (5-diol), 5-diol-sulfate, 5-diol-fatty acid esters, and androstenedione in both men and women between the ages of 20–80 yr. In the 50- to 60-yr-old group, serum DHEA decreased by 74% and 70% from its peak values in 20- to 30-yr-old men and women, respectively. The serum concentrations of the conjugated metabolites of dihydrotestosterone (DHT), namely androsterone (ADT)-G, androstane-3α,17β-diol (3α-diol-G), androstane-3β,17β-diol (3β-diol-G), and ADT-sulfate are the most reliable parameters of the total androgen pool in both men and women, whereas serum testosterone and DHT can be used as markers of testicular secretion in men and interstitial ovarian secretion in women. The serum concentration of these various conjugated androgen metabolites decreased by 40.8% to 72.8% between the 20- to 30-yr-old and 70- to 80-yr-old age groups in men and women, respectively, thus suggesting a parallel decrease in the total androgen pool with age. As estimated by measurement of the circulating levels of these conjugated metabolites of DHT, it is noteworthy that women produce approximately 66% of the total androgens found in men. In women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues, whereas in men the testes and DHEA and DHEA-S provide approximately equal amounts of androgens at the age of 50–60 yr. An additional potentially highly significant observation is that the majority of the marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes are observed after the age of 60 yr.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dihydroepiandrosterone sulphate concentrations decrease with ageing; in men aged 70-80 years they are only about 20% of peak concentrations at age 20 years.
“Dihydroepiandrosterone sulphate is a precursor to testosterone, with concentrations that also decrease with ageing—in men aged 70–80 years, dihydroepiandrosterone sulphate concentrations are only about 20% of their peak concentrations at the age of 20 years.78”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [78]
In the 50-to 60-yr-old age group, serum DHEA has already decreased by 70% compared with the 20-to 30-yr-old peak values.
“in the 50-to 60-yr-old age group, serum DHEA has already decreased by 70%, compared with the 20-to 30-yr-old peak values (Ref.23; Fig. 1).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Serum androgens as well as their precursors and metabolites decrease from the age of 30-40 yr in women.
“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Women produce approximately 71% or two thirds of the total androgens synthesized in men.
“As assessed by measurement of the circulating levels of these conjugated metabolites of DHT, it can be estimated that women produce approximately 71% or two thirds of the total androgens synthesized in men (Table 1);”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Total androgen production in women is more than two thirds, or 71%, of that observed in men, based on the sum of serum concentrations of ADT-G, 3α-diol-G, and 3β-diol-G.
“an estimate of the relative amount of total androgens in women and men calculated on the basis of the sum of the serum concentrations of these three metabolites suggests that total androgen production in women is more than two thirds, or 71%, of that observed in men (23,27).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Changes in precursor androgen secretion by the adrenals precede by 10-20 yr the detectable decrease in ovarian steroidogenesis that occurs abruptly at menopause.
“the changes in precursor androgen secretion by the adrenals precede by 10 -20 yr the detectable decrease in ovarian steroidogenesis that occurs abruptly at menopause (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
In women, most androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues.
“in women, most of these androgens originate from the transformation of DHEA and DHEA-S into testosterone and DHT in peripheral intracrine tissues.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
The decrease in serum conjugated androgen metabolites suggests a parallel decrease in the total androgen pool with age.
“thus suggesting a parallel decrease in the total androgen pool with age (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Serum concentration of conjugated androgen metabolites decreases by 47.5-72.7% between the 20-30 and 70-80 yr age groups in women.
“The serum concentration of the aboveindicated conjugated androgen metabolites decreases by 47.5-72.7% between the 20-to 30-and 70-to 80-yr age groups in women,”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Women at menopause are not only deprived from estrogens because of rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of progressive decrease of serum DHEA levels starting years before menopause.
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
The pool of androgens in women decreases progressively from age 30 yr in parallel with the decrease in serum concentration of DHEA and DHEA-S.
“the pool of androgens in women decreases progressively from the age of 30 yr in parallel with the decrease in the serum concentration of DHEA and DHEA-S (23).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
The decline of testosterone and DHEA with age could be at least partially responsible for sarcopenia in older men and women.
“The decline of testosterone and DHEA (23,26,321,322) with age could be at least partially responsible for sarcopenia in older men and women.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146 · see citing works
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349 · see citing works
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104 · see citing works
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Self-citationChanges in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437 · see citing works
Self-citationNeuronal migration and contact guidance in the primate telencephalon.
RAKIC, P. T. (1978) · PubMed · Cited by 395 · see citing works
Vermeulen, A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-221 · Cited by 393 · see citing works
The, V. L., Lachance, Y., Labrie, C., Leblanc, G., Thomas, J. L., Strickler, R. C., & Labrie, F. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1310 · Cited by 309 · see citing works
Self-citationComplete androgen blockade for the treatment of prostate cancer.
Labrie, F., Dupont, A., & Bèlanger, A. (1985) · PubMed · Cited by 285 · see citing works
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citationMIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-9-1051 · Cited by 260 · see citing works
Rhéaume, E., Simard, J., Morel, Y., Mebarki, F., Zachmann, M., Forest, M. G., New, M. I., & Labrie, F. (1992) · Nature Genetics · doi:10.1038/ng0792-239 · Cited by 235 · see citing works
Self-citationLuu-The, V., Zhang, Y., Poirier, D., & Labrie, F. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00209-x · Cited by 224 · see citing works
Self-citationBélanger, B., Bélanger, A., Labrie, F., Dupont, A., Cusan, L., & Monfette, G. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90514-1 · Cited by 212 · see citing works
Self-citationStructure of human type II 5 alpha-reductase gene
Labrie, F., Sugimoto, Y., Luu-The, V., Simard, J., Lachance, Y., Bachvarov, D. R., Leblanc, G., Durocher, F., & Paquet, N. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505484 · Cited by 203 · see citing works
Self-citationTreatment of Prostate Cancer with Gonadotropin-Releasing Hormone Agonists
Labrie, F., Dupont, A., Bèlanger, A., St‐Arnaud, R., Giguère, M., Lacourcière, Y., Emond, J., & Monfette, G. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-1-67 · Cited by 179 · see citing works
Self-citationSimultaneous radioimmunoassay of progestins, androgens and estrogens in rat testis
Bèlanger, A., Caron, S., & Picard, V. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90190-9 · Cited by 177 · see citing works
Sex Steroids and Bone Density in Premenopausal and Perimenopausal Women
STEINBERG, K. K., Freni-Titulaer, L. W., Depuey, E. G., MILLER, D. T., Sgoutas, D. S., Coralli, C. H., Phillips, D. L., Rogers, T., & Clark, R. V. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-533 · Cited by 176 · see citing works
Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate.
LABRIE, C., BELANGER, A., & LABRIE, F. (1988) · Endocrinology · doi:10.1210/endo-123-3-1412 · Cited by 167 · see citing works
Self-citationStanozolol in postmenopausal osteoporosis: Therapeutic efficacy and possible mechanisms of action
Chesnut, C. H., Ivey, J. L., Gruber, H. E., Matthews, M., Nelp, W. B., Sisom, K., & Baylink, D. J. (1983) · Metabolism · doi:10.1016/0026-0495(83)90027-6 · Cited by 165 · see citing works
Labrie, F., Simard, J., Luu-The, V., Bélanger, A., & Pelletier, G. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90308-6 · Cited by 132 · see citing works
Self-citationRodbard, D. (1974) · Endocrinology · doi:10.1210/endo-94-5-1427 · Cited by 116 · see citing works
Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.
BÉLANGER, A., BROCHU, M., & CLICHE, J. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-812 · Cited by 108 · see citing works
MAUVAIS-JARVIS, P., Charransol, G., & Masson, F. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-3-452 · Cited by 106 · see citing works
Origin of Plasma Androstanediol Glucuronide in Men*
Moghissi, E. S., Ablan, F., & Horton, R. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-417 · Cited by 102 · see citing works
Steingold, K. A., de Ziegler, D., Cedars, M. I., Meldrum, D. R., Lu, J. K. H., Judd, H. L., & Chang, R. J. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-773 · Cited by 95 · see citing works
Science behind total androgen blockade: from gene to combination therapy.
Labrie, F., Bèlanger, A., Dupont, A., The, V. L., Simard, J., & Labrie, C. (1993) · PubMed · Cited by 91 · see citing works
Self-citationDennefors, B., Janson, P. O., Knutson, F., & Hamberger, L. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90625-0 · Cited by 75 · see citing works
Free Estradiol, Free Testosterone, and Sex Hormone-Binding Globulin in Perimenopausal Women*
Longcope, C., Hui, S. L., & Johnston, C. C. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-513 · Cited by 72 · see citing works
LABRIE, Y., DUROCHER, F., LACHANCE, Y., TURGEON, C., SIMARD, J., LABRIE, C., & LABRIE, F. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.849 · Cited by 64 · see citing works
Self-citationPlasma hormone profiles after the menopause and bilateral oöphorectomy.
Jw, S., Chakravarti, S., & Collins, W. P. (1978) · PubMed · Cited by 43 · see citing works
Bone density is normal in male rats treated with finasteride
Rosen, H. N., Tollin, S. R., Balena, R., Middlebrooks, V. L., Moses, A. C., Yamamoto, M., Zeind, A. J., & Greenspan, S. L. (1995) · Endocrinology · doi:10.1210/endo.136.4.7895648 · Cited by 40 · see citing works
Increase in Plasma Steroid Glucuronide Levels in Men from Infancy to Adulthood
Brochu, M., & Bélanger, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1283 · Cited by 35 · see citing works
Labrie, F., Simard, J., Luu-The, V., Bèlanger, A., Pelletier, G., Morel, Y., Mébarki, F., Sánchez, R., Durocher, F., Turgeon, C., et al. (1996) · Springer eBooks · doi:10.1007/978-3-662-03230-5_10 · Cited by 34 · see citing works
Self-citationLucisano, A., Russo, N., Acampora, M. G., Fabiano, A., Fattibene, M., Parlati, E., Maniccia, E., & Dell'Acqua, S. (1986) · Maturitas · doi:10.1016/0378-5122(86)90008-3 · Cited by 34 · see citing works
Bèlanger, A., Labrie, F., Dupont, A., Brochu, M., & Cusan, L. (1988) · PubMed · Cited by 24 · see citing works
Self-citationUnconjugated and Glucuronide Steroid Levels in Human Breast Cyst Fluid
Bèlanger, A., Labrie, F., & Angeli, A. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17795.x · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846 · see citing works
Practice Bulletin No. 183: postpartum hemorrhage
(2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002351 · Cited by 1,406 · see citing works
Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102 · see citing works
Knop, E., Knop, N., Millar, T., Obata, H., & Sullivan, D. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6997c · Cited by 1,079 · see citing works
Androgen Levels in Adult Females: Changes with Age, Menopause, and Oophorectomy
Davison, S. L., Bell, R., Donath, S., Montalto, J. G., & Davis, S. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0212 · Cited by 998 · see citing works
Sources of estrogen and their importance
Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00360-1 · Cited by 936 · see citing works
Khosla, S., Amin, S., & ORWOLL, E. S. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0002 · Cited by 934 · see citing works
Simpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K., Britt, K., Speed, C., & Jones, M. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081601.142703 · Cited by 773 · see citing works
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717 · see citing works
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
Baulieu, E.-E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M.-P., Latour, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4279 · Cited by 577 · see citing works
Estrogen and cognitive functioning in women
Sherwin, B. B. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0016 · Cited by 560 · see citing works
Prevalence of Dry Eye Disease Among US Men
Schaumberg, D. A. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.103 · Cited by 557 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Self-citationKroboth, P. D., Salek, F. S., Pittenger, A. L., Fabian, T. J., & Frye, R. F. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007903 · Cited by 523 · see citing works
Minireview: Aromatase and the Regulation of Estrogen Biosynthesis--Some New Perspectives
Simpson, E. R., & Davis, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.11.8547 · Cited by 501 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
Is dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Self-citationTFOS DEWS II Sex, Gender, and Hormones Report
Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 451 · see citing works
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418 · see citing works
Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model
Yue, X., Lu, M. G. W., Lancaster, T., Cao, P., Honda, S., Staufenbiel, M., Harada, N., Zhong, Z., Shen, Y., & Li, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505203102 · Cited by 393 · see citing works
Laughlin, G. A., Barrett-Connor, E. L., Kritz‐Silverstein, D. C., & von Mühlen, D. G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6405 · Cited by 381 · see citing works
Pathophysiology of Age-Related Bone Loss and Osteoporosis
Khosla, S., & Riggs, B. L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.07.009 · Cited by 376 · see citing works
Goswami, S. K. (2004) · Human Reproduction · doi:10.1093/humrep/deh359 · Cited by 372 · see citing works
Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366 · see citing works
Self-citationRandolph, J. F., Sowers, M. R., Gold, E. B., Mohr, B. A., Luborsky, J. L., Santoro, N., McConnell, D. S., Finkelstein, J. S., Korenman, S. G., Matthews, K. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020777 · Cited by 363 · see citing works
Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J.-L., & Candas, B. (1998) · Steroids · doi:10.1016/s0039-128x(98)00007-5 · Cited by 347 · see citing works
Self-citationAndrogen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye
Sullivan, D. A., Sullivan, B. D., EVANS, J. E., Schirra, F., Yamagami, H., LIU, M., Richards, S. M., Suzuki, T., Schaumberg, D. A., Sullivan, R. M., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04217.x · Cited by 343 · see citing works
Weill-Engerer, S., David, J.-P., Sazdovitch, V., Liere, P., Eychenne, B., Pianos, A., Schumacher, M., Delacourte, A., Baulieu, E.-E., & Akwa, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020878 · Cited by 333 · see citing works
Marx, C., Petros, S., Bornstein, S. R., Weise, M., Wendt, M., Menschikowski, M., Engelmann, L., & Höffken, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000063282.83188.3d · Cited by 324 · see citing works
The endocrine system and ageing
Chahal, H., & Drake, W. (2007) · The Journal of Pathology · doi:10.1002/path.2110 · Cited by 306 · see citing works
Morgan, C. A., Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., & Charney, D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.819 · Cited by 304 · see citing works
Androgen therapy in women: An Endocrine Society clinical practice guideline
Wierman, M. E., Basson, R., Davis, S. R., Khosla, S., Miller, K. K., Rosner, W., & Santoro, N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1121 · Cited by 301 · see citing works
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
Schumacher, M., Weill‐Engerer, S., Lière, P., Robert, F., Franklin, R. J. M., García‐Segura, L. M., Lambert, J. J., Mayo, W., Melcangi, R. C., Párducz, Á., et al. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.004 · Cited by 296 · see citing works
Goldstat, R., Briganti, E. M., Tran, J., Wolfe, R. S., & Davis, S. R. (2003) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000060256.03945.20 · Cited by 296 · see citing works
Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4306 · Cited by 292 · see citing works
Self-citationAge-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates
Ferrari, E., Cravello, L., Muzzoni, B., Casarotti, D., Paltro, M., Sb, S., Fioravanti, M., Cuzzoni, G., Pontiggia, B., & Magri, F. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440319 · Cited by 288 · see citing works
Estrogen—the Good, the Bad, and the Unexpected
Simpson, E. R., Misso, M., Hewitt, K. N., Hill, R. A., Boon, W. C., Jones, M. E., Kovacic, A., Zhou, J., & Clyne, C. D. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0020 · Cited by 266 · see citing works
Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface
Krenzer, K. L., Dana, M. R., Ullman, M. D., Cermak, J. M., Tolls, D. B., Evans, J. E., & Sullivan, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7072 · Cited by 266 · see citing works
Clarke, B. L., & Khosla, S. (2010) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2010.02.014 · Cited by 258 · see citing works
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249 · see citing works
Labrie, F., Archer, D. F., Koltun, W. D., Vachon, A., Young, D. G., Frenette, L., Portman, D. J., Montesino, M., Côté, I., Parent, J., et al. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000571 · Cited by 247 · see citing works
Self-citationCorrelates of Circulating Androgens in Mid-Life Women: The Study of Women’s Health Across the Nation
Santoro, N., Torréns, J. I., Crawford, S. L., Allsworth, J. E., Finkelstein, J. S., Gold, E. B., Korenman, S. G., Lasley, W. L., Luborsky, J. L., McConnell, D. S., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2063 · Cited by 246 · see citing works
Testosterone for peri and postmenopausal women
Somboonporn, W., Bell, R. J., & Davis, S. R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004509.pub2 · Cited by 245 · see citing works
Identification of androgen receptor protein and 5alpha -reductase mRNA in human ocular tissues
Rocha, E. M. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.1.76 · Cited by 239 · see citing works
Couillard, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.3.1026 · Cited by 237 · see citing works
Salivary cortisol and dehydroepiandrosterone in relation to puberty and gender
Netherton, C. M., Goodyer, I. M., Tamplin, A., & Herbert, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00150-6 · Cited by 231 · see citing works
Clarke, B. L., & Khosla, S. (2008) · Steroids · doi:10.1016/j.steroids.2008.10.003 · Cited by 225 · see citing works
Frontiers in the Use of Biomarkers of Health in Research on Stress and Aging
Piazza, J. A., Almeida, D. M., Dmitrieva, N., & Klein, L. C. (2010) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbq049 · Cited by 221 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“…enzymatically inactivated in the same cell prior to efflux; (6) no significant amount of active hormones are released from the cell into the extracellular space (s paracrinology) or circulation (s endocrinology) to prevent a systemic excess of active hormones (Labrie, 1991; Labrie et al., 1997a).”
InfluentialMilner, M. S., Beckman, K. A., Luchs, J., Allen, Q. B., Awdeh, R. M., Berdahl, J. P., Boland, T. S., Buznego, C., Gira, J. P., Goldberg, D. F., et al. (2017) · Current Opinion in Ophthalmology · doi:10.1097/01.icu.0000512373.81749.b7 · Cited by 214 · see citing works
Women’s Sexual Desire and Arousal Disorders
Brotto, L. A., Bitzer, J., Laan, E. T. M., Leiblum, S. R., & Luria, M. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01630.x · Cited by 210 · see citing works
Léránth, C., Hajszán, T., & MacLusky, N. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4516-03.2004 · Cited by 206 · see citing works
Parker, C. R. (1999) · Steroids · doi:10.1016/s0039-128x(99)00046-x · Cited by 202 · see citing works
Androgen influence on the meibomian gland.
Sullivan, D. A., Sullivan, B. D., Ullman, M. D., Rocha, E. M., Krenzer, K. L., Cermak, J. M., Toda, I., Doane, M. G., Evans, J. E., & Wickham, L. A. (2000) · PubMed · Cited by 201 · see citing works
Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology
Goodyer, I. M., Park, R. J., Netherton, C. M., & Herbert, J. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.3.243 · Cited by 197 · see citing works
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 196 · see citing works
Local estrogen biosynthesis in males and females.
Simpson, E. R., Rubin, G., Clyne, C. D., Robertson, K. M.-P., O’Donnell, L., Davis, S. R., & Jones, M. E. E. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060131 · Cited by 195 · see citing works
Laughlin, G. A., & Barrett-Connor, E. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6861 · Cited by 195 · see citing works
Goodarzi, M. O., Carmina, E., & Azziz, R. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.06.003 · Cited by 191 · see citing works
Testosterone influences libido and well being in women
Davis, S. R., & Tran, J. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00333-7 · Cited by 184 · see citing works
Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies
Tchernof, A., & Labrie, F. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510001 · Cited by 183 · see citing works
Self-citationAlzheimer?s disease: the impact of age-related changes in reproductive hormones
Meethal, S. V., & Atwood, C. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4381-3 · Cited by 182 · see citing works
Influence of Aging on the Polar and Neutral Lipid Profiles in Human Meibomian Gland Secretions
Sullivan, B. D. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.9.1286 · Cited by 178 · see citing works
Johannsson, G., Burman, P., Wirén, L., Engström, B. E., Nilsson, A. G., Ottosson, M., Jonsson, B., Bengtsson, B.-Å., & Karlsson, F. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8494 · Cited by 175 · see citing works
The grey mouse lemur: A non-human primate model for ageing studies
Languille, S., Blanc, S., Blin, O. J., Canale, C. I., Dal‐Pan, A., Devau, G., Dhénain, M., Dorieux, O., Epelbaum, J., Gomez, D., et al. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.07.001 · Cited by 175 · see citing works
Diurnal and Seasonal Cortisol, Testosterone, and DHEA Rhythms in Boys and Girls during Puberty
Matchock, R. L., Dorn, L. D., & Susman, E. J. (2007) · Chronobiology International · doi:10.1080/07420520701649471 · Cited by 174 · see citing works
Dehydroepiandrosterone as a regulator of immune cell function
Hazeldine, J., Arlt, W., & Lord, J. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.016 · Cited by 173 · see citing works
DHEA and DHEA-S response to acute psychosocial stress in healthy men and women
Lennartsson, A.-K., Kushnir, M. M., Bergquist, J., & Jonsdottir, I. H. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.003 · Cited by 173 · see citing works
Dehydroepiandrosterone: A neuroactive steroid
Stárka, L., Dušková, M., & Hill, M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.03.008 · Cited by 170 · see citing works
Truong, S., Cole, N., Stapleton, F. J., & Golebiowski, B. (2014) · Clinical and Experimental Optometry · doi:10.1111/cxo.12147 · Cited by 166 · see citing works
Schumacher, M., Guennoun, R., Ghoumari, A. M., Massaad, C., Robert, F., El‐Etr, M., Akwa, Y., Rajkowski, K. M., & Baulieu, É.-É. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0050 · Cited by 165 · see citing works
Novel mechanisms for DHEA action
Prough, R. A., Clark, B. J., & Klinge, C. M. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0013 · Cited by 163 · see citing works
Assessment of steroidogenesis and steroidogenic enzyme functions
Luu-The, V. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.05.017 · Cited by 161 · see citing works
Legro, R. S., Kunselman, A. R., Demers, L., Wang, S. C., Bentley–Lewis, R., & Dunaif, A. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8387 · Cited by 161 · see citing works
(2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000177709.65944.b0 · Cited by 160 · see citing works
Davison, S. L., & Davis, S. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00204-8 · Cited by 159 · see citing works
Female reproductive system and bone
Clarke, B. L., & Khosla, S. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.07.006 · Cited by 154 · see citing works
Complete Androgen Insensitivity Syndrome
Sullivan, B. D. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.12.1689 · Cited by 153 · see citing works
Aging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 145 · see citing works
Aromatization of androgens in women: current concepts and findings
Simpson, E. R. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02984-9 · Cited by 144 · see citing works
Traish, A. M., Vignozzi, L., Simon, J. A., Goldstein, I., & Kim, N. N. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.03.005 · Cited by 142 · see citing works
Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients
Ritsner, M. S., Maayan, R., Gibel, A., Strous, R. D., Modai, I., & Weizman, A. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.09.003 · Cited by 140 · see citing works
DHEA Replacement for Postmenopausal Women
Davis, S. R., Panjari, M., & Stanczyk, F. Z. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2888 · Cited by 139 · see citing works
Androgens and Dry Eye in Sjögren's Syndromea
Sullivan, D. A., Wickham, L. A., Rocha, E. M., Krenzer, K. L., Sullivan, B. D., Steagall, R. J., Cermak, J. M., Dana, M. R., Ullman, M. D., Sato, É. H., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07656.x · Cited by 137 · see citing works
Aging: A Predisposition to Dry Eyes
Sharma, A., & Hindman, H. B. (2014) · Journal of Ophthalmology · doi:10.1155/2014/781683 · Cited by 135 · see citing works
Role of aromatase in sex steroid action
SIMPSON, E. R. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250149 · Cited by 134 · see citing works
Endocrine Aspects of Women’s Sexual Function
Wierman, M. E., Nappi, R. E., Avis, N. E., Davis, S. R., Labrie, F., Rosner, W., & Shifren, J. L. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01629.x · Cited by 132 · see citing works
Self-citationTearful Relationships? Sex, Hormones, the Lacrimal Gland, and Aqueous-Deficient Dry Eye
Sullivan, D. A. (2004) · The Ocular Surface · doi:10.1016/s1542-0124(12)70147-7 · Cited by 132 · see citing works
Metabolism of DHEA in postmenopausal women following percutaneous administration
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Chaussade, V., Castiel, I., et al. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.034 · Cited by 129 · see citing works
Self-citationParker, C., Slayden, S. M., Azziz, R., Crabbe, S. L., Hines, G. A., Boots, L. R., & Bae, S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6265 · Cited by 129 · see citing works
A 20-Year Follow-up of Young Women With Polycystic Ovary Syndrome
Carmina, E., Campagna, A. M., & Lobo, R. A. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31823f7135 · Cited by 128 · see citing works
Altıntaş, Ö., Caglar, Y., Yüksel, N., Demırcı, A., & Karabas, L. V. (2004) · Ophthalmologica · doi:10.1159/000076148 · Cited by 126 · see citing works
Puberty in Nonhuman Primates and Humans
Plant, T. M., & Witchel, S. F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50045-2 · Cited by 123 · see citing works
Amin, S., & Felson, D. T. (2001) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70186-1 · Cited by 123 · see citing works
Gordon, C. M., Grace, E., Emans, S. J., Goodman, E., CRAWFORD, M. H., & LeBoff, M. S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.1.136 · Cited by 123 · see citing works
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 122 · see citing works
Sex-Steroid Imbalance in Females and Dry Eye
Versura, P., Giannaccare, G., & Campos, E. C. (2014) · Current Eye Research · doi:10.3109/02713683.2014.966847 · Cited by 120 · see citing works
Sullivan, B. D., Evans, J. E., Krenzer, K. L., Dana, M. R., & Sullivan, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4866 · Cited by 120 · see citing works
Somner, J., McLellan, S., Cheung, J., Mak, Y. T., Frost, M. L., KNAPP, K. M., Wierzbicki, A. S., Wheeler, M. J., Fogelman, I., Ralston, S. H., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030164 · Cited by 120 · see citing works
- Authors
- Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Laboratory of Molecular Endocrinology, CHUL Research Center, Le Centre Hospitalier Universitaire de Québec, and Laval University, Québec, G1V 4G2, Canada
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-08-01
- Volume
- 82
- Issue
- 8
- Pages
- 2396-2402
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2009110883
- Cited by
- 713
- References
- 37
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 4 · 2023: 24 · 2022: 22 · 2021: 17 · 2020: 15 · 2019: 25 · 2018: 28 · 2017: 28 · 2016: 18 · 2015: 18 · 2014: 31 · 2013: 25 · 2012: 39
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- aging, dehydroepiandrosterone, DHEA sulfate, androstenedione, dihydrotestosterone, androstanol, androgen metabolism, sex steroids, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Androgens, Androstenedione, Dehydroepiandrosterone, Female, Humans, Male, Middle Aged, Pregnenolone, Protein Precursors, Reference Values, Gonadal Steroid Hormones, Dihydrotestosterone, 17-Hydroxysteroid Dehydrogenases, Androstenediol, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
