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Optic Nerve Damage in Human Glaucoma: II. The Site of Injury and Susceptibility to Damage
Abstract
We examined the histologic structure of the optic nerve head in 15 eyes of nine persons with a known glaucoma history. All had been seeing eyes, varying from normal visual acuity and visual field to advanced glaucoma damage. The site of damage to nerve fibers is the scleral lamina cribrosa, where there is local blockage of axonal transport. Early cup size increase prior to definite field loss results from loss of nerve fibers, not from damage to astrocytic glial cells of the nerve head. No selective damage to nerve head capillaries is seen in mildly damaged specimens. Scanning electron microscopic analysis suggests that the structure of the lamina cribrosa is an important determinant of the degree of susceptibility to damage by elevated intraocular pressure.
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Citations
Cited by
The Pathophysiology and Treatment of Glaucoma: A Review
Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210
Jonas, J. B., Aung, T., Bourne, R. R., Bron, A. M., Ritch, R., & Panda-Jonas, S. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31469-1 · Cited by 1,322
Morphologic Changes in the Lamina Cribrosa Correlated with Neural Loss in Open-Angle Glaucoma
Quigley, H. A., Hohman, R. M., Addicks, E. M., Massof, R. W., & Green, W. R. (1983) · American Journal of Ophthalmology · doi:10.1016/0002-9394(83)90389-6 · Cited by 680
Self-citationChronic human glaucoma causing selectively greater loss of large optic nerve fibers
Quigley, H. A., Dunkelberger, G. R., & Green, W. R. (1988) · Ophthalmology · doi:10.1016/s0161-6420(88)33176-3 · Cited by 563
Self-citationGupta, N. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.086769 · Cited by 434
Metadata
- Authors
- Quigley, H. A.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1981-04-01
- Volume
- 99
- Issue
- 4
- Pages
- 635
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1969824248
- Cited by
- 1,244
- References
- 0
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quigley, H. A. (1981). Optic Nerve Damage in Human Glaucoma: II. The Site of Injury and Susceptibility to Damage. Archives of Ophthalmology. https://doi.org/10.1001/archopht.1981.03930010635009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
