Cited by 434Glaucoma and retinal disordersDrug-Induced Ocular ToxicityCerebral Venous Sinus Thrombosis

Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

Open access
Gupta, N·2006·British Journal of Ophthalmology

Abstract

The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.

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Crossref · 10.1136/bjo.2005.086769

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  1. Yu ¨cel YH, Zhang Q, Gupta N, et al. Loss of neurons in magnocellular and parvocellular layers of the LGN in glaucoma. Arch Ophthalmol 2000;118:378-84.

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Authors
Gupta, N.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Gupta, N
Venue
British Journal of Ophthalmology
Publisher
BMJ
Published
2006-06-01
Volume
90
Issue
6
Pages
674-678
ISSN
0007-1161 (ISSN-L)
OpenAlex
W2133684905
Cited by
434
References
21
Citations by year
2026: 11 · 2025: 25 · 2024: 18 · 2023: 11 · 2022: 32 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 17 · 2016: 24 · 2015: 26 · 2014: 22 · 2013: 25 · 2012: 31
FWCI
13.67
Type
journal article
Language
en
Open access
Locations
  • British Journal of Ophthalmology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Glaucoma Research Foundation
  • Glaucoma Research Society of Canada
  • University of Toronto
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
  • Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
Keywords
glaucoma, neurodegeneration, lateral geniculate nucleus, visual cortex, optic nerve head, visual field defects, clinicopathological correlation, neuropathology
MeSH terms
Aged, Aged, 80 and over, Brain, Female, Geniculate Bodies, Glaucoma, Open-Angle, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Afferent, Optic Nerve, Optic Nerve Diseases, Visual Cortex, Visual Fields, Neurodegenerative Diseases

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