Chronic human glaucoma causing selectively greater loss of large optic nerve fibers
Open accessAbstract
Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter of optic nerve fibers. In some eyes, automated perimetry had been performed. Optic nerve fibers larger than the mean diameter were killed more rapidly than smaller fibers, although no fiber size was completely spared at any stage of atrophy. The number of optic nerve fibers varies considerably among normal eyes. The authors confirmed that the death of a substantial proportion of optic nerve fibers precedes detectable visual field loss.
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Glaucoma is an age-related multifactorial neurodegenerative disease of the optic nerve, with an irreversible decrease in retinal ganglion cells, causing visual-field loss and cupping of the optic nerve head.
“Glaucoma is an age-related multifactorial neurodegenerative disease of the optic nerve, with an irreversible decrease in RGCs, causing a visual-field loss and cupping of the optic nerve head (Quigley et al., 1988).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Quigley et al., 1988
Cites
Optic Nerve Damage in Human Glaucoma
Quigley, H. A. (1981) · Archives of Ophthalmology · doi:10.1001/archopht.1981.03930010635009 · Cited by 1,246 · see citing works
Self-citationOptic Nerve Damage in Human Glaucoma
Quigley, H. A. (1982) · Archives of Ophthalmology · doi:10.1001/archopht.1982.01030030137016 · Cited by 1,177 · see citing works
Self-citationQuigley, H. A., & Addicks, E. M. (1981) · Archives of Ophthalmology · doi:10.1001/archopht.1981.03930010139020 · Cited by 686 · see citing works
Self-citationMorphologic Changes in the Lamina Cribrosa Correlated with Neural Loss in Open-Angle Glaucoma
Quigley, H. A., Hohman, R. M., Addicks, E. M., Massof, R. W., & Green, W. R. (1983) · American Journal of Ophthalmology · doi:10.1016/0002-9394(83)90389-6 · Cited by 680 · see citing works
Self-citationThe Effect of Age on the Nerve Fiber Population of the Human Optic Nerve
Balazsi, A. G., Rootman, J., Drance, S. M., Schulzer, M., & Douglas, G. R. (1984) · American Journal of Ophthalmology · doi:10.1016/0002-9394(84)90509-9 · Cited by 502 · see citing works
Chronic glaucoma selectively damages large optic nerve fibers.
Quigley, H. A., Sanchez, R. M., Dunkelberger, G. R., L'Hernault, N. L., & Baginski, T. A. (1987) · PubMed · Cited by 444 · see citing works
Self-citationQuigley, H. A., & Green, W. R. (1979) · Ophthalmology · doi:10.1016/s0161-6420(79)35338-6 · Cited by 332 · see citing works
Self-citationNeuroretinal Rim Area in Early Glaucoma
Airaksinen, P. J., Drance, S. M., & Schulzer, M. (1985) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)75856-8 · Cited by 157 · see citing works
Anatomy of the Lamina Cribrosa in Human Eyes
Radius, R. L., & Gonzalés, M. (1981) · Archives of Ophthalmology · doi:10.1001/archopht.1981.03930021035010 · Cited by 156 · see citing works
Blood vessels of the glaucomatous optic disc in experimental primate and human eyes.
Quigley, H. A., Hohman, R. M., Addicks, E. M., et al. (1984) · PubMed · Cited by 100 · see citing works
Self-citationThe number and diameter distribution of axons in the monkey optic nerve.
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Self-citationLaser-Induced Primate Glaucoma
Pederson, J. E. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040031373030 · Cited by 88 · see citing works
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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works
Schlamp, C. L., Li, Y., Dietz, J. A., Janssen, K. T., & Nickells, R. W. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-66 · Cited by 303 · see citing works
Gallego, B. I., Salazar, J. J., de Hoz, R., Rojas, B., Ramírez, A. I., Salinas-Navarro, M., Ortín-Martínez, A., Valiente-Soriano, F. J., Avilés-Trigueros, M., Villegas-Perez, M. P., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-92 · Cited by 224 · see citing works
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Ultrastructure of the human retina in aging and various pathological states
Nag, T. C., & Wadhwa, S. (2012) · Micron · doi:10.1016/j.micron.2012.01.011 · Cited by 88 · see citing works
Yu, H., Zhong, H., Li, N., Chen, K., Chen, J., Sun, J., Xu, L., Wang, J., Zhang, M., Liu, X., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002218r · Cited by 33 · see citing works
- Authors
- Quigley, H. A., Dunkelberger, G. R., & Green, W. R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Quigley, Harry A.
- ORCID
- Quigley, Harry A.
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 1988-03
- Volume
- 95
- Issue
- 3
- Pages
- 357-363
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W1993051562
- Cited by
- 563
- References
- 12
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 9 · 2018: 14 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 8 · 2013: 10 · 2012: 16
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ophthalmology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Glaucoma Research Foundation
- National Eye Institute (#EY01765, EY 02120, EY-06888)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Keywords
- glaucoma, optic atrophy, fiber diameter, intraocular pressure elevation, visual field defects, automated perimetry
- MeSH terms
- Aged, Aged, 80 and over, Chronic Disease, Female, Glaucoma, Humans, Male, Nerve Fibers, Optic Atrophy, Optic Disk, Optic Nerve, Retinal Ganglion Cells, Visual Fields
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