Cited by 349Retinal Diseases and TreatmentsTrace Elements in HealthRetinal Development and Disorders

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Oral Zinc in Macular Degeneration

Newsome, D. A., Swartz, M., Leone, N. C., Elston, R. C., Miller, E.·1988·Archives of Ophthalmology

DOI 10.1001/archopht.1988.01060130202026

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Abstract

Macular degeneration associated with age and drusen, an important cause of severe visual loss in older persons, is of unknown cause. The sensory retina and retinal pigment epithelium, which are cell layers in zinc, appear to be prominently involved in the disease process. Because zinc plays a role in the metabolic function of several important enzymes in the chorioretinal complex, we undertook a prospective, randomized, double-masked, placebo-controlled investigation of the effects of oral zinc administration on the visual acuity outcome in 151 subjects with drusen or macular degeneration. Although some eyes in the zinc-treated group lost vision, this group had significantly less visual loss than the placebo group after a follow-up of 12 to 24 months. This is the first controlled oral intervention study to show a positive, if limited, treatment effect in macular degeneration, a major public health problem. Because of the pilot nature of the study and the possible toxic effects and complications of oral zinc administration, widespread use of zinc in macular degeneration is not now warranted.

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Authors: Newsome, D. A., Swartz, M., Leone, N. C., Elston, R. C., & Miller, E.
Affiliations: Louisiana State University (US)
University of Utah (US)
Utah State University (US)
ORCID: Elston, R. C.
Venue: Archives of Ophthalmology
Publisher: American Medical Association (AMA)
Published: 1988-02-01
Volume: 106
Issue: 2
Pages: 192-198
ISSN: 0003-9950 (ISSN-L)
DOI: 10.1001/archopht.1988.01060130202026
OpenAlex: W2007111898
Cited by: 349
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 14
FWCI: 14.37
Type: journal article
Language: en
Open access: closed
Locations: Archives of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: macular degeneration, oral zinc supplementation, drusen, age-related macular degeneration, visual acuity, retinal pigment epithelium, zinc toxicity, blindness prevention
MeSH terms: Administration, Oral, Adult, Aged, Aged, 80 and over, Clinical Trials as Topic, Double-Blind Method, Female, Fluorescein Angiography, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Random Allocation, Zinc

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Oral Zinc in Macular Degeneration

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