Cited by 304Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

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Laser Photocoagulation of Subfoveal Neovascular Lesions of Age-Related Macular Degeneration: Updated Findings From Two Clinical Trials

·1993·Archives of Ophthalmology

DOI 10.1001/archopht.1993.01090090052019

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Abstract

OBJECTIVE: To report 3- and 4-year visual outcomes in eyes followed up in two randomized clinical trials of laser photocoagulation for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration. DESIGN AND MAIN OUTCOME MEASURES: Eyes of consenting patients were assigned randomly to laser treatment or no treatment. Visual acuity, reading speed, and contrast threshold were measured before random assignment, 3 and 6 months later, and at 6-month intervals thereafter. Visual acuities of treated and untreated eyes were compared 4 years after enrollment, in the Subfoveal New CNV Study (eyes without prior laser treatment), and 3 years after enrollment, in the Subfoveal Recurrent CNV Study (eyes with subfoveal recurrent CNV at the periphery of an earlier laser treatment scar). RESULTS: Four years after enrollment in the Subfoveal New CNV Study, 39 (47%) of 83 untreated eyes and 17 (22%) of 77 laser-treated eyes had lost 6 or more lines of visual acuity from baseline levels (P = .002). At the 3-year examination in the Subfoveal Recurrent CNV Study, 21 (36%) of 58 untreated eyes and six (12%) of 49 treated eyes had lost 6 or more lines of visual acuity from baseline levels (P = .009). Comparisons based on contrast threshold and reading speed for enlarged text also favored laser treatment in both trials. CONCLUSIONS: Stronger evidence favoring laser photocoagulation of subfoveal CNV has been provided by continued follow-up of patients enrolled in these two clinical trials. The benefits of laser treatment have persisted through at least 4 years of follow-up in the Subfoveal New CNV Study and 3 years of follow-up in the Subfoveal Recurrent CNV Study.

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Venue: Archives of Ophthalmology
Publisher: American Medical Association (AMA)
Published: 1993-09-01
Volume: 111
Issue: 9
Pages: 1200
ISSN: 0003-9950 (ISSN-L)
DOI: 10.1001/archopht.1993.01090090052019
OpenAlex: W4251720370
Cited by: 303
References: 0
Citations by year: 2026: 3 · 2025: 6 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 7
FWCI: 5.91
Type: journal article
Language: en
Open access: closed
Locations: Archives of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01ey002546-07, 5u01ey002547-07)
National Eye Institute (EY02547, EY02546, EY02548)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: laser photocoagulation, subfoveal choroidal neovascularization, age-related macular degeneration, visual acuity outcomes, long-term follow-up, recurrent CNVs, contrast threshold, reading speed
MeSH terms: Aged, Aged, 80 and over, Choroid, Female, Fluorescein Angiography, Follow-Up Studies, Fovea Centralis, Fundus Oculi, Humans, Macular Degeneration, Male, Middle Aged, Neovascularization, Pathologic, Reading, Recurrence, Sensory Thresholds, Visual Acuity, Contrast Sensitivity, Laser Coagulation

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Laser Photocoagulation of Subfoveal Neovascular Lesions of Age-Related Macular Degeneration: Updated Findings From Two Clinical Trials

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