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Cited by 469Retinal Diseases and TreatmentsOcular Diseases and Behçet’s SyndromeRetinal and Macular Surgery

Choroidal neovascularization

Grossniklaus, Hans E., Green, W.Richard·2004·American Journal of Ophthalmology
DOI 10.1016/j.ajo.2003.09.042
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Abstract

Purpose To review clinicopathologic findings of choroidal neovascularization (CNV) in a historical framework with emphasis on pathobiology and correlation with treatment.Design Selective literature review combined with authors' experience.Results Choroidal neovascularization represents a stereotypic, nonspecific response to a specific stimulus. Although CNV differs among patients, the general growth patterns are subretinal pigment epithelium (type 1), subretinal (type 2), or combined. Choroidal neovascularization occurs over time in dynamic stages of initiation, active and involutional. Treatments are now being designed based on modern understanding of CNV growth.Conclusions Progress continues to be made concerning understanding the pathobiology and treatment of CNV.

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Crossref · 10.1016/j.ajo.2003.09.042

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  • In choroidal neovascularization, vessels eventually break through the RPE, resulting in severe clinical phenotypes including neovascular AMD, hemorrhagic AMD, and disciform AMD.

    “These vessels eventually break through the RPE (60), resulting in severe clinical phenotypes including (a) neovascular AMD, where lipid-rich fluid accumulates under the RPE and/or neural retina; (b) hemorrhagic AMD, where blood breaks through the RPE into the subretinal space; and (c) disciform AMD, where fibrous tissue with NV and altered RPE proliferates and replaces neural retina.”

    From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [60]

  • Early choroidal neovascularisation occurs under the retinal pigment epithelium, eventually breaking through to develop exudative, haemorrhagic, or disciform age-related macular degeneration.

    “Early choroidal neovascularisation occurs under the retinal pigment epithelium,133,134 eventually breaking through135 to develop exudative, haemorrhagic, or disciform age-related macular degeneration (figure 6).”

    From Age-related macular degeneration (2008) · cites this paper as [135]

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Authors
Grossniklaus, H. E., & Green, W. R.
Affiliations
  • Emory University (US)
  • Johns Hopkins University (US)
Corresponding author
Grossniklaus, Hans E.
ORCID
Grossniklaus, Hans E.
Venue
American Journal of Ophthalmology
Publisher
Elsevier BV
Published
2004-03
Volume
137
Issue
3
Pages
496-503
ISSN
0002-9394 (ISSN-L)
DOI
10.1016/j.ajo.2003.09.042
OpenAlex
W4233657213
Semantic Scholar
d23b181b1572296b7f9ccedf26a00eb54dea0824
Cited by
469
References
77
Citations by year
2026: 15 · 2025: 16 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 39 · 2020: 50 · 2019: 25 · 2018: 23 · 2017: 18 · 2016: 23 · 2015: 28 · 2014: 18 · 2013: 20 · 2012: 19
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (U10 13165)
  • National Eye Institute (P-30-EY06360, P30EY006360)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
Keywords
choroidal neovascularization, pathobiology, clinicopathological correlation, subretinal pigment epithelium, subretinal neovascularization, age-related macular degeneration
MeSH terms
Humans, Choroidal Neovascularization

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