The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
TUNEL-Positive Ganglion Cells in Human Primary Open-angle Glaucoma
Abstract
OBJECTIVE: To determine whether retinal ganglion cell death in primary open-angle glaucoma occurs by apoptosis. METHODS: Eighteen eyes of 17 subjects with documented primary open-angle glaucoma were compared with 21 control eyes that were group matched for age, race, and sex. Staging of glaucoma severity was performed by histologic optic nerve evaluation. Fixed, paraffin-embedded retinal sections were assayed by the TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (UTP)-biotin nick end-labeling) method to detect the internucleosomal DNA fragmentation that is characteristic of apoptosis. RESULTS: A positive TUNEL reaction was observed among ganglion layer cells in 10 of 18 cases with glaucoma, compared with 1 of 11 control cases without confounding systemic disease (5 control eyes were excluded owing to artifactual staining and 4 eyes had confounding systemic disease). Sections containing more than 250,000 cells in the ganglion cell layer were examined in cases and controls. The frequency of TUNEL-positive cells in the ganglion cell layer in cases with glaucoma was 1.76 per 10,000, or 15.2 times greater than the control frequency from individuals without confounding disease (P < .001; 95% CI, 2.46-623). Eyes without glaucoma from subjects with diabetes and amyotrophic lateral sclerosis showed more positive cells than other controls. CONCLUSION: Apoptosis seems to be a mechanism of cell death in human eyes with primary open-angle glaucoma.
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Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis.
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Cited by
Barber, A. J., Lieth, E., Khin, S. A., Antonetti, D. A., Buchanan, A. G., & Gardner, T. W. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2425 · Cited by 1,295
Weinreb, R. N., Leung, C. K. S., Crowston, J. G., Medeiros, F. A., Friedman, D. S., Wiggs, J. L., & Martin, K. R. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.67 · Cited by 632
A new view of diabetic retinopathy: a neurodegenerative disease of the eye
Barber, A. J. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00023-x · Cited by 622
The role of oxidative stress in glaucoma
IZZOTTI, A., BAGNIS, A., & SACCA, S. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2005.11.001 · Cited by 536
Retinal ganglion cells in diabetes
Kern, T. S., & Barber, A. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156695 · Cited by 422
Metadata
- Authors
- Kerrigan, L. A.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1997-08-01
- Volume
- 115
- Issue
- 8
- Pages
- 1031
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1964022954
- Cited by
- 465
- References
- 34
- FWCI
- 18.52
- Type
- journal article
- Language
- en
- Open access
- closed
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