The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Neurobiologic Antecedents of Schizophrenia in Children: Evidence for an Inherited, Congenital Neurointegrative Defect
Abstract
In chronic schizophrenics, disordered motor development in childhood is followed by more early cognitive and social impairment and poorer outcome; childhood schizophrenics represent the most extreme variants of this. Preschizophrenic infants show a fluctuating dysregulation of maturation--or "pandevelopmental retardation" (PDR)--that involves physical growth; gross motor, visual-motor, and cognitive development; proprioceptive and vestibular responses; muscle tone; and possibly arousal. Pandevelopmental retardation was significantly related to a genetic history for schizophrenia (less than .05), but not to obstetric complications. The severity of PDR was significantly related to the severity of later psychiatric and cognitive disorder (less than .01). Pandevelopmental retardation provides a "marker" in infancy for the inherited neurointegrative defect in schizophrenia. These disordered functions should be studied by anyone interested in the biology of the schizophrenic genotype or in specific early interventions for children at risk.
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Cites
Studies in the Childhood Psychoses I. Diagnostic Criteria and Classification
Kolvin, I. (1971) · British Journal of Psychiatry · doi:10.1192/bjp.118.545.381 · Cited by 468
A Five to Fifteen Year Follow-up Study of Infantile Psychosis: I. Description of Sample
Rutter, M., & Lockyer, L. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1169 · Cited by 356
Irrelevant and metaphorical language in early infantile autism
KANNER, L. (1946) · American Journal of Psychiatry · doi:10.1176/ajp.103.2.242 · Cited by 343
Language in Childhood Psychosis: A Review
Baltaxe, C. A. M., & Simmons, J. Q. (1975) · Journal of Speech and Hearing Disorders · doi:10.1044/jshd.4004.439 · Cited by 58
Cited by
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Lieberman, J. A., Perkins, D., Belger, A., Chakos, M., Jarskog, F., Boteva, K., & Gilmore, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01303-8 · Cited by 593
Behavioral and Intellectual Markers for Schizophrenia in Apparently Healthy Male Adolescents
Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1328 · Cited by 582
Significance and meaning of neurological signs in schizophrenia
(1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.1.11 · Cited by 431
Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings.
Seidman, L. J. (1983) · Psychological Bulletin · doi:10.1037//0033-2909.94.2.195 · Cited by 320
Metadata
- Authors
- Fish, B.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1977-11-01
- Volume
- 34
- Issue
- 11
- Pages
- 1297
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1990060408
- Cited by
- 292
- References
- 4
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neurobiologic Antecedents of Schizophrenia in Children: Evidence for an Inherited, Congenital Neurointegrative Defect. https://app.cochat.ai/papers/10.1001/archpsyc.1977.01770230039002
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- Fish, B. (1977). Neurobiologic Antecedents of Schizophrenia in Children: Evidence for an Inherited, Congenital Neurointegrative Defect. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1977.01770230039002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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