Behavioral and Intellectual Markers for Schizophrenia in Apparently Healthy Male Adolescents
Abstract
Objective Subtle behavioral and intellectual abnormalities are often present in apparently healthy adolescents who later develop schizophrenia. The authors investigated whether these abnormalities can predict vulnerability for schizophrenia before the first psychotic manifestation. Method The study consisted of linking the Israeli Draft Board Registry with the National Psychiatric Hospitalization Case Registry. The draft board tests measure intelligence, social functioning, organizational ability, interest in physical activity, and individual autonomy. Patients (N = 509) were compared to nonpatients, i.e., adolescents not appearing in the National Psychiatric Registry (N = 9,215), matched to patients by age, gender, and school attended at time of testing. Results Healthy male adolescents who were later hospitalized for schizophrenia had significantly lower test scores on all measures than adolescents not reported to the National Psychiatric Registry. The strongest predictors for schizophrenia were deficits in social functioning, organizational ability, and intellectual functioning. When patients were compared to matched nonpatients, the prediction model had a 75% sensitivity, a 100% specificity, a positive predictive value of 72%, and an overall rate of correct classification of 87.5%. Applied to the Israeli Draft Board Registry, the model yielded a sensitivity of 74.7%, a validated specificity of 99.7%, and a positive predictive value of 42.7%. Conclusions This study demonst…
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Cognitive impairment is already evident during adolescence in individuals that will subsequently develop schizophrenia.
“and cognitive impairment is already evident during adolescence in individuals that will subsequently develop schizophrenia 54 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [54]
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- Authors
- Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M.
- Affiliations
- Tel Aviv University (IL)
- Venue
- American Journal of Psychiatry
- Published
- 1999-09-01
- Volume
- 156
- Issue
- 9
- Pages
- 1328-1335
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2118907570
- Cited by
- 582
- References
- 3
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 13 · 2018: 7 · 2017: 15 · 2016: 18 · 2015: 22 · 2014: 23 · 2013: 31 · 2012: 28
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, schizophrenia risk prediction, adolescents, intelligence, social functioning, organizational skills, early detection, prodromal psychosis, psychiatric hospitalization, early intervention, adolescent boys
- MeSH terms
- Adolescent, Psychology, Adolescent, Disease Susceptibility, Hospitalization, Hospitals, Psychiatric, Humans, Intelligence Tests, Israel, Male, Military Personnel, Psychological Tests, Psychometrics, Registries, Risk Factors, Schizophrenia, Social Adjustment, Social Behavior, Cohort Studies, Logistic Models
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