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Cited by 332

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Differential Symptom Reduction by Drugs and Psychotherapy in Acute Depression

DiMascio, Alberto·1979·Archives of General Psychiatry

Abstract

A randomized, controlled trial compared the combination of amitriptyline hydrochloride and short-term interpersonal psychotherapy, either treatment alone, and a nonscheduled treatment control group in ambulatory acute, nonbipolar, nonpsychotic depressives. Results show the efficacy of both psychotherapy and amitriptyline in overall symptom reduction. Amitriptyline and psychotherapy were about equal, and the effects of both treatments in combination were additive. The additive effect of combined treatment was largely due to the differential effects of the two treatments. Amitriptyline had its effect mainly on the vegetative symptoms of depression such as sleep and appetite disturbance, these occurred early in treatment, often within the first week. Psychotherapy had its effect mainly on mood, suicidal ideation, work, and interests; these effects occurred slightly later, at four to eight weeks.

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Crossref · 10.1001/archpsyc.1979.01780130068008

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Metadata

Authors
DiMascio, A.
Venue
Archives of General Psychiatry
Published
1979-12-01
Volume
36
Issue
13
Pages
1450
ISSN
0003-990X (ISSN-L)
OpenAlex
W2149632089
Cited by
332
References
3
FWCI
11.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Differential Symptom Reduction by Drugs and Psychotherapy in Acute Depression. https://app.cochat.ai/papers/10.1001/archpsyc.1979.01780130068008
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DiMascio, A. (1979). Differential Symptom Reduction by Drugs and Psychotherapy in Acute Depression. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1979.01780130068008

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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