The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hypothalamic-Pituitary-Adrenal Axis Activity in Depressive Illness: Its Relationship to Classification
Abstract
Serum cortisol response to the 1-mg overnight dexamethasone suppression test was studied in 221 depressed patients and 109 nondepressed psychiatric controls. Nonsuppression distinguished patients with primary unipolar depression (65/146) from patients with secondary unipolar depression (0/42) and nondepressed controls (0/109). Furthermore, nonsuppression distinguished the three familial subtypes of primary unipolar depressive illness: familial pure depressive disease (FPDD; 38/50 patients), sporadic depressive disease (SDD; 24/55 patients), and depression spectrum disease (3/41 patients). Moderate elevations in baseline serum cortisol levels were found in FPDD, SDD, and bipolar depression. Medication did not affect the results. The data suggest that the depressive syndrome is composed of separate illnesses, each of which has a distinctive pattern of hypothalamic-pituitary-adrenal axis activity during the depressed state as well as a specific clinical and familial psychiatric history.
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Citations
Cites
Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness
Carroll, B. J., Martin, F. I. R., & Davies, B. (1968) · BMJ · doi:10.1136/bmj.3.5613.285 · Cited by 279
Cited by
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Charney, D. S. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780350094011 · Cited by 649
The Natural History of Alcoholism
Taylor, J. R., & Helzer, J. E. (1983) · The Biology of Alcoholism · doi:10.1007/978-1-4684-4274-8_2 · Cited by 622
The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry: Commentary and Review
Arana, G. W. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790350067012 · Cited by 526
The Dexamethasone Suppression Test and Suicide Prediction
Coryell, W., & Schlesser, M. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.5.748 · Cited by 304
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Metadata
- Authors
- Schlesser, M. A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1980-07-01
- Volume
- 37
- Issue
- 7
- Pages
- 737
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2001407351
- Cited by
- 387
- References
- 1
- FWCI
- 26.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schlesser, M. A. (1980). Hypothalamic-Pituitary-Adrenal Axis Activity in Depressive Illness: Its Relationship to Classification. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1980.01780200015001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
