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Cited by 649

The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression

Charney, Dennis S.·1981·Archives of General Psychiatry
DOI 10.1001/archpsyc.1981.01780350094011
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Abstract

Considerable evidence suggests that the acute effects of antidepressant treatments on brain norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their delayed therapeutic action. This review evaluates the effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function. In contrast to variable effects on NE and 5-HT turnover and on presynaptic receptor sensitivity almost all long-term antidepressant treatments produce consistent alterations in a number of measures of postsynaptic amine receptor sensitivity. Long-term treatment has been found to reduce beta-adrenergic sensitivity while enhancing responses to serotonergic and alpha-adrenergic stimulation, suggesting that modulation of receptor sensitivity may be a mechanism of action common to tricyclic antidepressants, "atypical" antidepressants, monoamine oxidase inhibitors, and electroconvulsive therapy. These findings provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies of amine receptor function in patients.

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Metadata

Authors
Charney, D. S.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1981-10-01
Volume
38
Issue
10
Pages
1160
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1981.01780350094011
OpenAlex
W1965174921
Cited by
649
References
189
FWCI
59.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression. https://app.cochat.ai/papers/10.1001/archpsyc.1981.01780350094011
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Charney, D. S. (1981). Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1981.01780350094011

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.