Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

Carroll, B. J.; Martin, F. I. R.; Davies, Brian

doi:10.1136/bmj.3.5613.285

Cited by 279Stress Responses and CortisolAdrenal Hormones and DisordersTreatment of Major Depression

Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

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Carroll, B. J., Martin, F. I. R., Davies, Brian·1968·BMJ

DOI 10.1136/bmj.3.5613.285PMC PMC1986248

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Abstract

Use of the midnight dexamethasone suppression test showed that the plasma 11-hydroxycorticosteroid (11-O.H.C.S.) level did not undergo its normal reduction in 14 out of 27 patients with severe depression. Resistance to dexamethasone suppression correlated with the clinical rating of the severity of depression, while recovery from depression was associated with return of normal responsiveness to dexamethasone. The explanation of these findings is unknown.

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The dexamethasone suppression test (DST) identifies insufficient suppression of cortisol following dexamethasone intake.
“The first test to detect HPA axis alterations was the dexamethasone suppression test (DST), which identifies an insufficient suppression of cortisol following dexamethasone intake [48].”
From The HPA Axis as Target for Depression (2024) · cites this paper as [48]
The Subjects and Methods and Results sections describe measuring plasma 11-hydroxycorticosteroids after dexamethasone and finding insufficient suppression in some patients with severe depression. The paper does not establish that the DST was the first test to detect HPA-axis alterations, and it reports 11-hydroxycorticosteroids rather than specifically cortisol. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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Authors: Carroll, B. J., Martin, F. I. R., & Davies, B.
Affiliations: The Royal Melbourne Hospital (AU)
ORCID: Carroll, B. J.
Venue: BMJ
Publisher: BMJ
Published: 1968-08-03
Volume: 3
Issue: 5613
Pages: 285-287
ISSN: 0007-1447 (ISSN-L)
1468-5833
DOI: 10.1136/bmj.3.5613.285
PMC: PMC1986248
OpenAlex: W2055891857
Cited by: 279
References: 10
Citations by year: 2026: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 14 · 2012: 5
FWCI: 5.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: dexamethasone suppression test, 11-hydroxycorticosteroids, plasma corticosteroid levels, depression, severe depression, hypothalamic-pituitary-adrenal axis, depression severity, recovery from depression, glucocorticoid resistance
MeSH terms: Adolescent, Adult, Aged, Anorexia Nervosa, Anxiety, Circadian Rhythm, Depression, Dexamethasone, Fatigue, Mental Fatigue, Female, Fluorometry, Glucocorticoids, Humans, Male, Middle Aged, Pituitary-Adrenal Function Tests, Time Factors

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Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

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