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Cited by 366

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Pretreatment DST and Hypothalamic-Pituitary-Adrenocortical Function in Depressed Patients and Comparison Groups: A Multicenter Study

Stokes, Peter E.·1984·Archives of General Psychiatry
DOI 10.1001/archpsyc.1984.01790140047006
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Abstract

Pretreatment measures of hypothalamic-pituitary-adrenocortical (HYPAC) function in depressed, manic, and healthy normal subjects showed that nonsuppression on the dexamethasone suppression test (DST) had less positive predictive value for major diagnostic category and was more frequent in normals (8/77) than recently reported, although it was yet more frequent in depressed patients (35/111). Nonsuppression was common in manics (8/16), was similar in unipolar and bipolar depressed patients (35% and 27%, respectively), and did not segregate with melancholic, endogenous, or psychotic depression subtypes. Patterns of post-DST plasma cortisol concentration other than simple escape or nonescape from suppression were common. Nonsuppression of 9 AM plasma cortisol levels on the DST had as good or better diagnostic specificity as nonsuppression of any of three post-DST samples. Nonsuppression was not completely synonymous with HYPAC hypersecretion. Means of pre-DST HYPAC measures (morning plasma cortisol, urine free cortisol, and CSF cortisol levels) were elevated in depressed patients compared with normals. There were significant differences in HYPAC measures of depressed patients studied at different centers. Age correlated positively and body weight negatively with plasma cortisol level.

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Metadata

Authors
Stokes, P. E.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1984-03-01
Volume
41
Issue
3
Pages
257
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1984.01790140047006
OpenAlex
W2017475699
Cited by
366
References
37
FWCI
18.78
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Pretreatment DST and Hypothalamic-Pituitary-Adrenocortical Function in Depressed Patients and Comparison Groups: A Multicenter Study. https://app.cochat.ai/papers/10.1001/archpsyc.1984.01790140047006
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Stokes, P. E. (1984). Pretreatment DST and Hypothalamic-Pituitary-Adrenocortical Function in Depressed Patients and Comparison Groups: A Multicenter Study. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1984.01790140047006

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