The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Serotonergic Responsivity in Obsessive-Compulsive Disorder: Comparison of Patients and Healthy Controls
Abstract
To examine the "serotonin hypothesis" of obsessive-compulsive disorder (OCD), we studied the behavioral and neuroendocrine effects of metachlorophenylpiperazine (mCPP), a serotonergic agonist, in patients with OCD and healthy controls. Twelve patients and 20 controls were given a single dose of 0.5 mg/kg of mCPP, administered orally under double-blind, placebo-controlled, random-assignment conditions. Following mCPP, but not following placebo, patients with OCD experienced a transient but marked exacerbation of obsessive-compulsive symptoms. Moreover, compared with healthy controls, patients exhibited greater other behavioral (but not endocrinologic or thermal) changes after mCPP. These findings are consistent with a special role for the neurotransmitter serotonin in OCD psychopathology.
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Clomipramine Treatment of Obsessive-Compulsive Disorder: I. A Controlled Clinical Trial
Thorén, P. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780240079009 · Cited by 497
Obsessive-compulsive disorder and serotonin: Is there a connection?
Insel, T. R., Mueller, E. A., Alterman, I., Linnoila, M., & Murphy, D. L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90176-3 · Cited by 343
Cited by
Stein, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09620-4 · Cited by 352
Pathophysiology of obsessive–compulsive disorder
Aouizerate, B., Guehl, D., Cuny, E., Rougier, A., Bioulac, B., Tignol, J., & Burbaud, P. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.02.004 · Cited by 341
Toward a unified theory of serotonin dysregulation in eating and related disorders
Brewerton, T. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00001-5 · Cited by 245
Multiple pathways to functional impairment in obsessive-compulsive disorder
Markarian, Y., Larson, M. J., Aldea, M. A., Baldwin, S. A., Good, D., Berkeljon, A., Murphy, T. K., Storch, E. A., & McKay, D. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.09.005 · Cited by 252
Dold, M., Aigner, M., Lanzenberger, R., & Kasper, S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000740 · Cited by 211
Goodman, W. K., Grice, D. E., Lapidus, K. A. B., & Coffey, B. J. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2014.06.004 · Cited by 221
(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies
McCann, U. D., Eligulashvili, V., & Ricaurte, G. A. (2000) · Neuropsychobiology · doi:10.1159/000026665 · Cited by 190
Current animal models of obsessive compulsive disorder: a critical review
Joel, D. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.11.006 · Cited by 168
Fineberg, N. A., Hollander, E., Pallanti, S., Walitza, S., Grünblatt, E., Dell’Osso, B. M., Albert, U., Geller, D. A., Brakoulias, V., Janardhan Reddy, Y. C., et al. (2020) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000314 · Cited by 161
Self-citationNeurobiology of Obsessive-Compulsive Disorder:Serotonin and Beyond
Westenberg, H. G. M., Fineberg, N. A., & Denys, D. (2007) · CNS Spectrums · doi:10.1017/s1092852900002479 · Cited by 148
Compulsive behavior in the 5-HT2C receptor knockout mouse
Chou-Green, J. M., Holscher, T. D., Dallman, M. F., & Akana, S. F. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00047-7 · Cited by 143
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133
Children with obsessive-compulsive disorder: are they just “little adults”?
Kalra, S. K., & Swedo, S. E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37563 · Cited by 114
Hemmings, S. M. J., Kinnear, C. J., Lochner, C., Niehaus, D. J. H., Knowles, J. A., Moolman-Smook, J. C., Corfield, V. A., & Stein, D. J. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.05.007 · Cited by 108
A review of the role of serotonin system genes in obsessive-compulsive disorder
Sinopoli, V. M., Burton, C. L., Kronenberg, S., & Arnold, P. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.029 · Cited by 107
Fonseka, T. M., Richter, M. A., & Müller, D. J. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0510-8 · Cited by 93
MOORE, G. J., MACMASTER, F. P., STEWART, C., & ROSENBERG, D. R. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199806000-00017 · Cited by 85
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder
Wang, L., Simpson, H. B., & Dulawa, S. C. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832a80ad · Cited by 50
Wood, J., LaPalombara, Z., & Ahmari, S. E. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2017.0023 · Cited by 41
Metadata
- Authors
- Zohar, J.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1987-11-01
- Volume
- 44
- Issue
- 11
- Pages
- 946
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2065190583
- Cited by
- 370
- References
- 2
- FWCI
- 21.80
- Type
- journal article
- Language
- en
- Open access
- closed
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