Assessing the validity of current mouse genetic models of obsessive-compulsive disorder
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Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.
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OCD animal models have classically emphasized stereotyped and compulsive behaviors, and reliance on face validity may lead to discrepancies because identical phenotypes can result from different underlying biological processes.
“OCD animal models have classically emphasized the presence of stereotyped and compulsive behaviors, although reliance on face validity may lead to discrepancies in the field since identical phenotypes can result from different underlying biological processes (for review see Wang et al, 2009) 81.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [81]
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Shmelkov, S. V., Hormigo, A., Jing, D., Proenca, C. C., Bath, K. G., Milde, T., Shmelkov, E., Kushner, J. S., Baljevic, M., Dincheva, I., et al. (2010) · Nature Medicine · doi:10.1038/nm.2125 · Cited by 361 · see citing works
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209 · see citing works
Ting, J. T., & Feng, G. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.010 · Cited by 143 · see citing works
Ahmari, S. E., & Dougherty, D. D. (2015) · Depression and Anxiety · doi:10.1002/da.22367 · Cited by 128 · see citing works
Shanahan, N. A., Velez, L. P., Masten, V. L., & Dulawa, S. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.032 · Cited by 72 · see citing works
Self-citation
- Authors
- Wang, L., Simpson, H. B., & Dulawa, S. C.
- Affiliations
- University of Chicago (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Dulawa, Stephanie C.
- Venue
- Behavioural Pharmacology
- Published
- 2009-03
- Volume
- 20
- Issue
- 2
- Pages
- 119-133
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC2762389
- OpenAlex
- W2016619143
- Cited by
- 50
- References
- 209
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (K24MH091555, R24MH080022, K01MH071555, R01MH079424)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- obsessive-compulsive disorder, genetic mouse models, model validity, knockout mice, transgenic mice, genetic factors, neural mechanisms, animal models of psychiatric disorders
- MeSH terms
- Animals, Brain, Disease Models, Animal, Humans, Mice, Transgenic, Models, Genetic, Obsessive-Compulsive Disorder, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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