Cited by 50Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Assessing the validity of current mouse genetic models of obsessive-compulsive disorder

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Wang, Li, Simpson, Helen B., Dulawa, Stephanie C.·2009·Behavioural Pharmacology

Abstract

Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.

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  • OCD animal models have classically emphasized stereotyped and compulsive behaviors, and reliance on face validity may lead to discrepancies because identical phenotypes can result from different underlying biological processes.

    “OCD animal models have classically emphasized the presence of stereotyped and compulsive behaviors, although reliance on face validity may lead to discrepancies in the field since identical phenotypes can result from different underlying biological processes (for review see Wang et al, 2009) 81.”

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  1. Tobias R Walitza S Severe early-childhood obsessive-compulsive disorder--case report on a 4-year-old girl Z Kinder Jugendpsychiatr Psychother 2006 34 287 293 16927571

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Authors
Wang, L., Simpson, H. B., & Dulawa, S. C.
Affiliations
  • University of Chicago (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Dulawa, Stephanie C.
Venue
Behavioural Pharmacology
Published
2009-03
Volume
20
Issue
2
Pages
119-133
ISSN
0955-8810 (ISSN-L)
OpenAlex
W2016619143
Cited by
50
References
209
Citations by year
2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 4
FWCI
0.94
Type
journal article
Language
en
Open access
Locations
  • Behavioural Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health
  • National Institute of Mental Health (K24MH091555, R24MH080022, K01MH071555, R01MH079424)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
obsessive-compulsive disorder, genetic mouse models, model validity, knockout mice, transgenic mice, genetic factors, neural mechanisms, animal models of psychiatric disorders
MeSH terms
Animals, Brain, Disease Models, Animal, Humans, Mice, Transgenic, Models, Genetic, Obsessive-Compulsive Disorder, Mice, Knockout, Mice

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