Cited by 540Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

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A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures

Gur, Raquel E., Cowell, Patricia, Turetsky, Bruce I., Gallacher, Fiona, Cannon, Tyrone, Bilker, Warren, Gur, Ruben C.·1998·Archives of General Psychiatry

DOI 10.1001/archpsyc.55.2.145

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Abstract

BACKGROUND: Cross-sectional neuroanatomical studies have reported abnormalities in schizophrenia that relate to disease variables. Longitudinal neuroimaging investigations that integrate anatomical, clinical, and neurobehavioral measures may help clarify the pathogenesis of schizophrenia. METHODS: Magnetic resonance brain imaging and neurobehavioral studies were conducted at baseline and after 30.63 +/- 12.92 months (mean +/- SD) in 40 patients with schizophrenia (23 men and 17 women) and 17 healthy controls (13 men and 4 women). The schizophrenia group included 20 first-episode and 20 previously treated subjects. Volumes of whole-brain, cerebrospinal fluid, and frontal and temporal lobes were measured. The severity of negative and positive symptoms was assessed, medications were monitored, and neurobehavioral functioning in 8 domains was evaluated. RESULTS: Both first-episode and previously treated patients had smaller brains and frontal and temporal lobes than controls at intake. Longitudinally, reduction in frontal lobe volume was found only in patients, whereas temporal lobe reduction was also seen in controls. The association between volume reduction and symptom changes differed between patient groups, but volume reduction was associated with decline in some neurobehavioral functions in both groups. Exploratory analysis suggested that neuroleptic dose is correlated with changes in all 3 domains. CONCLUSIONS: The existence of neuroanatomical and neurobehavioral abnormalities in patients with first-episode schizophrenia indicates that the brain dysfunction occurred before clinical presentation. However, there is also evidence of progression, in which anatomical changes may affect some clinical and neurobehavioral features of the illness in some patients.

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Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Deficit and nondeficit forms of schizophrenia: the concept
Carpenter, W. T., Heinrichs, D. W., & Wagman, A. M. I. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.5.578 · Cited by 1,329
Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia
Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M. J., Wible, C. G., Hokama, H., Martin, J., Metcalf, D., Coleman, M., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208273270905 · Cited by 1,179
Neuropsychological Function in Schizophrenia
Saykin, A. J. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310036007 · Cited by 1,160
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086
Synopsis of Psychiatry
Kaplan, H. I., & Sadock, B. J. (1989) · International Clinical Psychopharmacology · doi:10.1097/00004850-198907000-00008 · Cited by 856
Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia
Barta, P. E., Pearlson, G. D., Powers, R. E., Richards, S. S., & Tune, L. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.11.1457 · Cited by 744
Brain Morphology and Schizophrenia: A Magnetic Resonance Imaging Study of Limbic, Prefrontal Cortex, and Caudate Structures
Breier, A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120009003 · Cited by 513

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Methionine Homozygosity at Codon 129 in the Prion Protein Is Associated with White Matter Reduction and Enlargement of CSF Compartments in Healthy Volunteers and Schizophrenic Patients
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Role of CpG context and content in evolutionary signatures of brain DNA methylation
Xin, Y., O’Donnell‐Luria, A., Ge, Y., Chanrion, B., Milekic, M. H., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., Gingrich, J. A., et al. (2011) · Epigenetics · doi:10.4161/epi.6.11.17876 · Cited by 33
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Wang, J., Hirayasu, Y., HIRAMATSU, K., Hokama, H., Miyazato, H., & Ogura, C. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00207-4 · Cited by 30
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Buka, S. L., Goldstein, J. M., Seidman, L. J., Zornberg, G. L., Donatelli, J.-A. L., Denny, L. R., & Tsuang, M. T. (1999) · Psychiatric Annals · doi:10.3928/0048-5713-19990301-11 · Cited by 30
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Boonstra, G., Cahn, W., Schnack, H. G., Pol, H. E. H., Minderhoud, T. C., Kahn, R. S., & van Haren, N. E. M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.018 · Cited by 29
Rightward cerebral asymmetry in subtypes of schizophrenia according to Leonhard's classification and to DSM-IV: a structural MRI study
Sallet, P. C., Elkis, H., Alves, T. M., Oliveira, J. R., Sassi, E., de Castro, C. C., Busatto, G. F., & Gattaz, W. F. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00020-9 · Cited by 29
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Velakoulis, D., Wood, S. J., McGorry, P. D., & Pantelis, C. (2000) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2000.00788.x · Cited by 29
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Roiz‐Santiáñez, R., Ayesa‐Arriola, R., Tordesillas‐Gutiérrez, D., de la Foz, V. O., Pérez‐Iglesias, R., Pazos, Á., Sánchez, E., & Crespo‐Facorro, B. (2013) · Psychological Medicine · doi:10.1017/s0033291713002365 · Cited by 30
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Bustillo, J., Wolff, C. R., Myers-y-Gutierrez, A., Dettmer, T. S., Cooper, T. B., Allan, A. M., Lauriello, J., & Valenzuela, C. F. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00528-5 · Cited by 26
Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders
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Gray matter features of schizotypal disorder patients exhibiting the schizophrenia‐related code types of the Minnesota Multiphasic Personality Inventory
Yoneyama, E., Matsui, M., Kawasaki, Y., Nohara, S., Takahashi, T., Hagino, H., Suzuki, M., Seto, H., & Kurachi, M. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.00202.x · Cited by 26
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Hartz, S. M., Ho, B., Andreasen, N. C., Librant, A. L., Rudd, D. S., Epping, E. A., & Wassink, T. H. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31033 · Cited by 23
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de Castro‐Manglano, P., Mechelli, A., Soutullo, C. A., Gimenez-Amaya, J., Ortuño, F., & McGuire, P. K. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.010 · Cited by 23
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Chan, W., Chia, M., Yang, G.-L., Woon, P., Sitoh, Y., Collinson, S. L., Nowinski, W. L., & Sim, K. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n5p388 · Cited by 22
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Children in Clinical Research: A Conflict of Moral Values
Sharav, V. H. (2003) · The American Journal of Bioethics · doi:10.1162/152651603322781639 · Cited by 23
Dissociative Model in Patients With Resistant Schizophrenia
Panov, G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.845493 · Cited by 24
Biomarkers in Psychosis: An Approach to Early Identification and Individualized Treatment
Mirzakhanian, H., Singh, F., & Cadenhead, K. S. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.134 · Cited by 21
Mitochondrial trafficking in neuropsychiatric diseases
Deheshi, S., Pasqualotto, B. A., & Rintoul, G. L. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.015 · Cited by 21
Overcoming Barriers to Research in Early Serious Mental Illness: Issues for Future Collaboration
HEINSSEN, R. K., Cuthbert, B. N., Breiling, J. P., Colpe, L. J., & Dolan‐Sewell, R. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007043 · Cited by 21
Prolongation of P300 latency is associated with the duration of illness in male schizophrenia patients
Mori, Y., 黒須, 貞., 廣山, 祐., & Niwa, S. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01695.x · Cited by 21
Intact Relational Memory and Normal Hippocampal Structure in the Early Stage of Psychosis
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Neurodevelopmental impairment, dopamine sensitisation, and social adversity in schizophrenia.
Murray, R. M., McDonald, C., & Bramon, E. (2002) · PubMed · Cited by 21
Deficit states in schizophrenia and their association with the length of illness and gender
Ronald Bottlender, A., Jäger, M., Groll, C., Strauß, A., & Möller, H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00007545 · Cited by 21
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Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia
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Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders
Mollon, J., Mathias, S. R., Knowles, E. E. M., Rodrigue, A., Koenis, M. M. G., Pearlson, G. D., Reichenberg, A., Barrett, J., Denbow, D., Aberizk, K., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291718003938 · Cited by 20
Regional specificity of cerebrospinal fluid abnormalities in first episode schizophrenia
Narr, K. L., Bilder, R. M., Woods, R. P., Thompson, P. M., Szeszko, P. R., Robinson, D. G., Ballmaier, M., Messenger, B. S., Wang, Y.-P., & Toga, A. W. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.10.005 · Cited by 20
Brain Imaging in Schizophrenia
Liddle, P. F., & Pantelis, C. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch22 · Cited by 20
Asymmetry of lexico-semantic processing in schizophrenia changes with disease progression
Lam, M., Collinson, S. L., Sim, K., Mackay, C. E., James, A. C., & Crow, T. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.10.020 · Cited by 19
Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia
Molina, V., Reig, S., SANZ, J., BENITO, C., Pascau, J., Francisco Collazos, D., Sarramea, F., Artaloytia, J. F., Gispert, J. D., & LUQUE, R. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00166-4 · Cited by 19
Pathophysiology of Schizophrenia
Falkai, P., Schmitt, A., & Cannon, T. D. (2011) · Wiley eBooks · doi:10.1002/9780470978672.ch2 · Cited by 18
Self-citation
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Chwa, W. J., Tishler, T. A., Raymond, C., Tran, C., Anwar, F., Villablanca, J. P., Ventura, J., Subotnik, K. L., Nuechterlein, K. H., & Ellingson, B. M. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.03.073 · Cited by 18
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Lobo, A. O., & Rojo, V. (2011) · Revista Española de Salud Pública · doi:10.1590/s1135-57272011000600002 · Cited by 19
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Fanni, D., Gerosa, C., Rais, M., Ravarino, A., Eyken, P. V., Fanos, V., & Faa, G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.063 · Cited by 17
Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Huang, J., Liu, C., Hwang, T., Chen, Y., Hsu, Y., Hwu, H., Lin, Y.-T., Hsieh, M. H., Liu, C., Chien, Y., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.23982 · Cited by 15
Veränderungen der Hirnstruktur durch neuroleptische Medikation
Scherk, H., & Falkai, P. (2004) · Der Nervenarzt · doi:10.1007/s00115-004-1793-5 · Cited by 16
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Maïza, O., Mazoyer, B., Hervé, P.-Y., Razafimandimby, A., Dollfus, S., & Tzourio-Mazoyer, N. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090103 · Cited by 15
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Stable deficits in gray matter volumes following a first episode of schizophrenia
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Morphometrical and morphological analysis of lateral ventricles in schizophrenia patients versus healthy controls
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A review of MRI studies of progressive brain changes in schizophrenia.
Okubo, Y., Saijo, T., & Oda, K. (2001) · PubMed · Cited by 10
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Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia
Molina, V., Sanz, J., Sarramea, F., Misiego, J. M., Carlos Benito, C., & Palomo, T. (2005) · European Psychiatry · doi:10.1016/j.eurpsy.2004.11.015 · Cited by 9
Anatomic Brain Imaging Studies of Normal and Abnormal Brain Development in Children and Adolescents
Giedd, J. N., Shaw, P., Wallace, G. L., Gogtay, N., & Lenroot, R. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch3 · Cited by 9
Sleep neurophysiology in childhood onset schizophrenia
Markovic, A., Buckley, A. W., Driver, D. I., Broadnax, D. D., Gochman, P., Hoedlmoser, K., Rapoport, J. L., & Tarokh, L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13039 · Cited by 8
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Feng, R., Womer, F. Y., Edmiston, E. K., Chen, Y., Wang, Y., Chang, M., Yin, Z., Wei, Y., Duan, J., Ren, S., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.579139 · Cited by 8
An MRI study of structural variations in schizophrenia using deformation field morphometry
Yoon, U., Lee, J., Kwon, J. S., Kim, H.-P., Shin, Y., Ha, T. H., Kim, I. Y., Chang, K. H., & Kim, S. I. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.12.005 · Cited by 8

Authors: Gur, R. E., Cowell, P., Turetsky, B. I., Gallacher, F., Cannon, T., Bilker, W., & Gur, R. C.
Affiliations: University of Pennsylvania (US)
ORCID: Gur, Raquel E.
Cowell, Patricia
Cannon, Tyrone
Bilker, Warren
Gur, Ruben C.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1998-02-01
Volume: 55
Issue: 2
Pages: 145
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.55.2.145
OpenAlex: W2126549748
Cited by: 540
References: 56
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 16 · 2012: 19
FWCI: 22.01
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k05mh001336-01)
National Institute of Mental Health (MH 43880, MH01336, MH-42191)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, longitudinal brain changes, frontal lobe volume, temporal lobe volume, brain atrophy, first-episode schizophrenia, neuroleptic dose, negative symptoms, positive symptoms, neurobehavioral function, cerebrospinal fluid volume
MeSH terms: Adult, Brain, Cross-Sectional Studies, Female, Follow-Up Studies, Frontal Lobe, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index, Temporal Lobe

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A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures

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