Cited by 540Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

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A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures

Gur, Raquel E., Cowell, Patricia, Turetsky, Bruce I., Gallacher, Fiona, Cannon, Tyrone, Bilker, Warren, Gur, Ruben C.·1998·Archives of General Psychiatry

DOI 10.1001/archpsyc.55.2.145

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Abstract

BACKGROUND: Cross-sectional neuroanatomical studies have reported abnormalities in schizophrenia that relate to disease variables. Longitudinal neuroimaging investigations that integrate anatomical, clinical, and neurobehavioral measures may help clarify the pathogenesis of schizophrenia. METHODS: Magnetic resonance brain imaging and neurobehavioral studies were conducted at baseline and after 30.63 +/- 12.92 months (mean +/- SD) in 40 patients with schizophrenia (23 men and 17 women) and 17 healthy controls (13 men and 4 women). The schizophrenia group included 20 first-episode and 20 previously treated subjects. Volumes of whole-brain, cerebrospinal fluid, and frontal and temporal lobes were measured. The severity of negative and positive symptoms was assessed, medications were monitored, and neurobehavioral functioning in 8 domains was evaluated. RESULTS: Both first-episode and previously treated patients had smaller brains and frontal and temporal lobes than controls at intake. Longitudinally, reduction in frontal lobe volume was found only in patients, whereas temporal lobe reduction was also seen in controls. The association between volume reduction and symptom changes differed between patient groups, but volume reduction was associated with decline in some neurobehavioral functions in both groups. Exploratory analysis suggested that neuroleptic dose is correlated with changes in all 3 domains. CONCLUSIONS: The existence of neuroanatomical and neurobehavioral abnormalities in patients with first-episode schizophrenia indicates that the brain dysfunction occurred before clinical presentation. However, there is also evidence of progression, in which anatomical changes may affect some clinical and neurobehavioral features of the illness in some patients.

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Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Deficit and nondeficit forms of schizophrenia: the concept
Carpenter, W. T., Heinrichs, D. W., & Wagman, A. M. I. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.5.578 · Cited by 1,329
Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia
Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M. J., Wible, C. G., Hokama, H., Martin, J., Metcalf, D., Coleman, M., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208273270905 · Cited by 1,179
Neuropsychological Function in Schizophrenia
Saykin, A. J. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310036007 · Cited by 1,160
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086
Synopsis of Psychiatry
Kaplan, H. I., & Sadock, B. J. (1989) · International Clinical Psychopharmacology · doi:10.1097/00004850-198907000-00008 · Cited by 856
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Barta, P. E., Pearlson, G. D., Powers, R. E., Richards, S. S., & Tune, L. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.11.1457 · Cited by 744
Brain Morphology and Schizophrenia: A Magnetic Resonance Imaging Study of Limbic, Prefrontal Cortex, and Caudate Structures
Breier, A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120009003 · Cited by 513

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Authors: Gur, R. E., Cowell, P., Turetsky, B. I., Gallacher, F., Cannon, T., Bilker, W., & Gur, R. C.
Affiliations: University of Pennsylvania (US)
ORCID: Gur, Raquel E.
Cowell, Patricia
Cannon, Tyrone
Bilker, Warren
Gur, Ruben C.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1998-02-01
Volume: 55
Issue: 2
Pages: 145
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.55.2.145
OpenAlex: W2126549748
Cited by: 540
References: 56
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 16 · 2012: 19
FWCI: 22.01
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k05mh001336-01)
National Institute of Mental Health (MH 43880, MH01336, MH-42191)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, longitudinal brain changes, frontal lobe volume, temporal lobe volume, brain atrophy, first-episode schizophrenia, neuroleptic dose, negative symptoms, positive symptoms, neurobehavioral function, cerebrospinal fluid volume
MeSH terms: Adult, Brain, Cross-Sectional Studies, Female, Follow-Up Studies, Frontal Lobe, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index, Temporal Lobe

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A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures

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