The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Common Genetic Vulnerability for Nicotine and Alcohol Dependence in Men
Abstract
BACKGROUND: Nicotine and alcohol dependence often occur together. We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences. METHODS: Subjects were 3356 male-male twin-pair members of the Vietnam Era Twin Registry who participated in a 1992 telephone administration of the Diagnostic Interview Schedule Version 3 Revised. Genetic model fitting was performed to estimate the magnitude and correlation of genetic and environmental contributions to lifetime nicotine and alcohol dependence. RESULTS: The heritability of nicotine dependence was 60.3% (95% confidence interval [CI], 55.4%-65.2%); that of alcohol dependence, 55.1% (95% CI, 49.7%-60.5%). The best-fitting model for the co-occurrence of lifetime nicotine and alcohol dependence included a substantial genetic correlation between both disorders (r = 0.68; 95% CI, 0.61-0.74) and a modest unique environmental correlation (r = 0.23; 95% CI, 0.14-0.32). CONCLUSIONS: These data suggest a common genetic vulnerability to nicotine and alcohol dependence in men. This common genetic influence may partially explain the clinical and epidemiological observations that alcoholics are often dependent smokers.
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Cites
Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Akaike, H. (1987) · Springer Series in Statistics · doi:10.1007/978-1-4612-1694-0_29 · Cited by 4,027
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005
Nicotine dependence, major depression, and anxiety in young adults
Breslau, N. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810360033005 · Cited by 634
DiFranza, J. R., & Guerrera, M. P. (1990) · Journal of Studies on Alcohol · doi:10.15288/jsa.1990.51.130 · Cited by 419
Cited by
Drug Dependence, a Chronic Medical Illness
McLellan, A. T., Lewis, D. C., O'Brien, C. P., & Kleber, H. D. (2000) · JAMA · doi:10.1001/jama.284.13.1689 · Cited by 2,622
The genetics of addictions: uncovering the genes
Goldman, D., Oroszi, G., & Ducci, F. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1635 · Cited by 1,099
The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies
Verhulst, B., Neale, M. C., & Kendler, K. S. (2015) · Psychological Medicine · doi:10.1017/s0033291714002165 · Cited by 652
Novel genes identified in a high-density genome wide association study for nicotine dependence
Bierut, L. J., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O. F., Swan, G. E., Rutter, J., Bertelsen, S., Fox, L., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl441 · Cited by 622
Self-citationAlcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 616
Metadata
- Authors
- True, W. R., Xian, H., Scherrer, J. F., Madden, P. A. F., Bucholz, K. K., Heath, A. C., Eisen, S. A., Lyons, M. J., Goldberg, J., & Tsuang, M.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1999-07-01
- Volume
- 56
- Issue
- 7
- Pages
- 655
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1972401127
- Cited by
- 455
- References
- 6
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- True, W. R., Xian, H., Scherrer, J. F., Madden, P. A. F., Bucholz, K. K., Heath, A. C., Eisen, S. A., Lyons, M. J., Goldberg, J., & Tsuang, M. (1999). Common Genetic Vulnerability for Nicotine and Alcohol Dependence in Men. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.56.7.655
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
