The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory
Open accessAbstract
CONTEXT: Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified. OBJECTIVE: To examine a series of haplotype blocks of single-nucleotide polymorphic markers from a segment of 1q42 spanning the disrupted-in-schizophrenia 1 (DISC1) and translin-associated factor X (TRAX) genes for association with schizophrenia and several endophenotypic traits thought to be involved in disease pathogenesis. DESIGN: Population-based twin cohort study. SETTING: Finland. PARTICIPANTS: Two hundred thirty-six subjects, consisting of 7 twin pairs concordant for schizophrenia (6 monozygotic [MZ] and 1 dizygotic [DZ]), 52 pairs discordant for schizophrenia (20 MZ and 32 DZ), and 59 demographically balanced normal pairs (28 MZ and 31 DZ), were drawn from a twin cohort consisting of all of the same-sex twins born in Finland from 1940 through 1957. MAIN OUTCOME MEASURES: Psychiatric diagnosis, performance on neurocognitive tests of short- and long-term memory, and gray matter volume measurements taken from high-resolution magnetic resonance images. RESULTS: A common haplotype incorporating 3 single-nucleotide polymorphic markers near the translocation break point of DISC1 (odds ratio, 2.6 [P = .02]) and a rare haplotype incorporating 4 markers from the DISC1 and TRAX genes (odds ratio, 13.0 [P = .001]) were significantly overrepresented among individuals with schizophrenia. These haplotypes were also associated with several quantitative endophenotypic traits previously observed to covary with schizophrenia and genetic liability to schizophrenia, including impairments in short- and long-term memory functioning and reduced gray matter density in the prefrontal cortex, as demonstrated using a population-based brain atlas method, with a trend toward association with reduced hippocampal volume. CONCLUSIONS: Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions. These effects are consistent with their production of proteins that play roles in neuritic outgrowth, neuronal migration, synaptogenesis, and glutamatergic neurotransmission.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“loss-of-function translocations in DISC1 are associated with high rates of mental illness129, and with reduced PFC grey matter and impaired working memory in patients with schizophrenia130.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [130]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Mutations in DISC1 are associated with high rates of mental illness120,121, and more subtle polymorphisms are associated with decreased PFC gray matter and impaired working memory122,123.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Coefficient of Agreement for Nominal Scales
Cohen, J. (1960) · Educational and Psychological Measurement · doi:10.1177/001316446002000104 · Cited by 42,398
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
Reitan, R. M., & Wolfson, D. E. (1993) · Medical Entomology and Zoology · Cited by 3,413
Scale for the Assessment of Negative Symptoms (SANS)*
(1989) · The British Journal of Psychiatry · doi:10.1192/s0007125000291502 · Cited by 2,710
Scale for Assessment of Positive Symptoms (SAPS) 1984
Andreasen, N. C. (1995) · Open Scholarship Institutional Repository (Washington University in St. Louis) · Cited by 2,423
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
WAIS-R manual : Wechsler adult intelligence scale-revised
Wechsler, D. (1981) · Medical Entomology and Zoology · Cited by 1,559
In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999) · Nature Neuroscience · doi:10.1038/13154 · Cited by 1,439
Self-citationStructured Clinical Interview for DSM-III-R Personality Disorders
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2012) · PsycTESTS Dataset · doi:10.1037/t07827-000 · Cited by 1,403
Flagged first, then by citations
Research works printed but not linked: 6
- Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, Hwang DR, Keilp J, Kochan L, Van Heertum R, Gorman JM, Laruelle M. Prefrontal do- pamine D1 receptors and working memory in schizophrenia. J Neurosci. 2002; 22:3708-3719.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
- Delis DJH, Kaplan E, Ober B. California Verbal Learning Test, Research Edition. Cleveland, Ohio: Psychological Corp; 1983.
- Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry. 2003;8:445-452.
- Roches- ter, Minn. Vol 2359. Bellingham, Wash: International Society for Optical Engi- neering; 1994:160-169.
- Ono M, Kubik S. CDA Atlas of the Cerebral Sulci. Stuttgart, Germany: Georg Thieme Verlag; 1990.
Cited by
Sorted by citations
Items 201–300 of 337
Prata, D., Mechelli, A., Picchioni, M., Fu, C. H. Y., Kane, F., Kalidindi, S., Mcdonald, C., Kravariti, E., Toulopoulou, T., Bramon, E., et al. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00665.x · Cited by 24
Gozes, I. (2010) · Peptides · doi:10.1016/j.peptides.2010.10.030 · Cited by 21
Effect of DISC1 on the P300 Waveform in Psychosis
Shaikh, M., Hall, M., Schulze, K., Dutt, A., Li, K., Williams, I., Walshe, M., Constante, M., Broome, M. R., Picchioni, M., et al. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr101 · Cited by 22
Trost, S., Platz, B., Usher, J., Scherk, H., Wobrock, T., Ekawardhani, S., Meyer, J., Reith, W., Falkai, P., & Gruber, O. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.10.006 · Cited by 26
Koyama, Y., Hattori, T., Shimizu, S., Taniguchi, M., Yamada, K., Takamura, H., Kumamoto, N., Matsuzaki, S., Ito, A., Katayama, T., et al. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.07.002 · Cited by 21
Strug, L. J., Addis, L., Chiang, T., Baskurt, Z., Li, W., Clarke, T., Hardison, H. H., Kugler, S. L., Mandelbaum, D. E., Novotny, E. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040696 · Cited by 20
Anjanappa, R. M., Purushottam, M., Kumar, H. B. G. K., Manduva, V., Krishna, N., Sriharsha, K. J., Reddy, Y. C. J., Ghosh, S., & Jain, S. (2012) · Journal of Human Genetics · doi:10.1038/jhg.2012.62 · Cited by 20
Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness
Johnstone, M., Maclean, A. W., Heyrman, L., Lenaerts, A., Nordin, A., Nilsson, L., Rijk, P. D., Goossens, D., Adolfsson, R., Clair, D. M. S., et al. (2015) · Complex Psychiatry · doi:10.1159/000438788 · Cited by 20
Waddington, J. L. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.191.50.s52 · Cited by 20
Vázquez-Bourgon, J., Mata, I., Roiz-Santiañez, R., Ayesa-Arriola, R., Suárez-Pinilla, P., Tordesillas-Gutiérrez, D., Vázquez-Barquero, J., & Crespo-Facorro, B. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.2.186 · Cited by 20
Gsandtner, I., & Freissmuth, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026757 · Cited by 18
O’Tuathaigh, C. M. P., Moran, P. M., Zhen, X., & Waddington, J. L. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13938 · Cited by 19
Koyama, Y., Hattori, T., Nishida, T., Hori, O., & Tohyama, M. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00052 · Cited by 16
Pathophysiology of Schizophrenia
Falkai, P., Schmitt, A., & Cannon, T. D. (2011) · Wiley eBooks · doi:10.1002/9780470978672.ch2 · Cited by 18
Self-citationAnimal Models of Schizophrenia
Lipska, B. K., & Gogos, J. A. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch22 · Cited by 19
The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia
Doyle, O., Bois, C., Thomson, P. A., Romaniuk, L., Whitcher, B. J., Williams, S., Turkheimer, F., Stefánsson, H., McIntosh, A. M., Mehta, M. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82636 · Cited by 18
Chasing genes for mood disorders and schizophrenia in genetically isolated populations
Venken, T., & Del‐Favero, J. (2007) · Human Mutation · doi:10.1002/humu.20582 · Cited by 18
DISC1 and Striatal Volume: A Potential Risk Phenotype For mental Illness
Chakravarty, M., Felsky, D., Tampakeras, M., Lerch, J., Mulsant, B., Kennedy, J., & Voineskos, A. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00057 · Cited by 21
Bradshaw, N. J., Ukkola‐Vuoti, L., Pankakoski, M., Zheutlin, A. B., Ortega‐Alonso, A., Torniainen‐Holm, M., Sinha, V., Therman, S., Paunio, T., Suvisaari, J., et al. (2017) · Open Biology · doi:10.1098/rsob.170153 · Cited by 17
Self-citationThe Cognitive Genetics of Neuropsychiatric Disorders
Corvin, A. P., Donohoe, G. J., Hargreaves, A., Gallagher, L., & Gill, M. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_188 · Cited by 17
The Genetics of Schizophrenia Converge Upon the NMDA Glutamate Receptor
Stahl, S. M. (2007) · CNS Spectrums · doi:10.1017/s1092852900021374 · Cited by 16
Okuda, A., Kishi, T., Okochi, T., Ikeda, M., Kitajima, T., Tsunoka, T., Okumukura, T., Fukuo, Y., Kinoshita, Y., Kawashima, K., et al. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8090-1 · Cited by 16
Whalley, H. C., Sussmann, J. E., Johnstone, M., Romaniuk, L., Redpath, H., Chakirova, G., Mukherjee, P., Hall, J., Johnstone, E. C., Lawrie, S. M., et al. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32035 · Cited by 15
Yang, Y., Nuechterlein, K. H., Phillips, O. R., Gutman, B. A., Kurth, F., Dinov, I. D., Thompson, P. M., Asarnow, R. F., Toga, A. W., & Narr, K. L. (2011) · Human Brain Mapping · doi:10.1002/hbm.21349 · Cited by 15
Self-citationDepue, B. E., & Banich, M. T. (2011) · Hippocampus · doi:10.1002/hipo.20952 · Cited by 15
Rice, G. M., Qi, Z., Selzer, R. R., Richmond, T., Thompson, K. J., Pauli, R. M., & Yu, J. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31349 · Cited by 15
Clinical impact of recently detected susceptibility genes for schizophrenia
Maier, W., Zobel, A. W., & Kühn, K.-U. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.1/wmaier · Cited by 15
Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis
Kähler, A., Rimol, L. M., Brown, A., Djurovic, S., Hartberg, C. B., Melle, I., Dale, A., Andreassen, O., & Agartz, I. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32076 · Cited by 15
Molecular Genetic Models Related to Schizophrenia and Psychotic Illness: Heuristics and Challenges
O’Tuathaigh, C. M. P., Desbonnet, L., Moran, P. M., Kirby, B. P., & Waddington, J. L. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_111 · Cited by 13
Arime, Y., Fukumura, R., Miura, I., Mekada, K., Yoshiki, A., Wakana, S., Gondo, Y., & Akiyama, K. (2014) · Behavioral and Brain Functions · doi:10.1186/1744-9081-10-45 · Cited by 16
Lv, Y., Wen, L., Hu, W.-J., Deng, C., Ren, H., Bao, Y.-N., Su, B.-W., Gao, P., Man, Z., Luo, Y.-Y., et al. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01271-x · Cited by 13
Interaction between DISC1 and CHL1 in regulation of neurite outgrowth
Ren, J., Zhao, T., Xu, Y., & Ye, H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.033 · Cited by 12
Kognitive Störungen bei schizophrenen Patienten
Volz, H., Reischies, F. M., & Riedel, M. J. (2009) · Der Nervenarzt · doi:10.1007/s00115-009-2819-9 · Cited by 10
Primate-Accelerated Evolutionary Genes: Novel Routes to Drug Discovery in Psychiatric Disorders
Moalic, J., Strat, Y. L., Lepagnol-Bestel, A.-M., Ramoz, N., Loe-Mie, Y., Maussion, G., Gorwood, P. A. P. M., & Simonneau, M. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790936338 · Cited by 12
Unlocking the molecular mechanisms of antipsychotics – a new frontier for discovery
Bowling, H. L., & Santini, E. (2016) · Swiss Medical Weekly · doi:10.4414/smw.2016.14314 · Cited by 12
Neurobiologicalendophenotypes of psychosis and schizophrenia
Pantelis, C., Yücel, M., Wood, S. J., Brewer, W. J., Fornito, A., Berger, G. E., Cannon, T. D., & Velakoulis, D. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576287.006 · Cited by 11
Self-citationChromosomal abnormalities and psychosis
Muir, W. J., Pickard, B. S., & Blackwood, D. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.023895 · Cited by 11
The Neurodevelopmental Model of Schizophrenia: Updated
Bearden, C. E., MEYER, S. E., Loewy, R. L., Niendam, T. A., & Cannon, T. D. (2015) · Wiley eBooks · doi:10.1002/9780470939406.ch14 · Cited by 11
Self-citationDisrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia
Norlelawati, A. T., Abdullah, K., Norsidah, K.-Z., Ramli, M., Tariq, A. R., & Taib, W. R. W. (2015) · Psychiatry Investigation · doi:10.4306/pi.2015.12.1.103 · Cited by 10
Sinha, V., Ukkola‐Vuoti, L., Ortega‐Alonso, A., Torniainen‐Holm, M., Therman, S., Tuulio‐Henriksson, A., Jylhä, P. J., Kaprio, J. A., Hovatta, I., Isometsä, E. T., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0429-x · Cited by 10
Self-citationUkkola‐Vuoti, L., Torniainen‐Holm, M., Ortega‐Alonso, A., Sinha, V., Tuulio‐Henriksson, A., Paunio, T., Lönnqvist, J. K., Suvisaari, J., & Hennah, W. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.003 · Cited by 9
Self-citationIn Silico Whole Genome Association Scan for Murine Prepulse Inhibition
Webb, B. T., McClay, J. L., Vargas-Irwin, C., York, T. P., & van den Oord, E. J. C. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005246 · Cited by 10
Rittenhouse, A. R., Ortiz-Miranda, S., & Jurczyk, A. (2021) · Neuronal Signaling · doi:10.1042/ns20180122 · Cited by 10
Mühle, C., Kreczi, J., Rhein, C., Richter-Schmidinger, T., Alexopoulos, P., Doerfler, A., Lenz, B., & Kornhuber, J. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1253-6 · Cited by 9
Deng, D., Jian, C., Lei, L., Zhou, Y., McSweeney, C., Dong, F., Shen, Y., Zou, D., Wang, Y., Wu, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21381 · Cited by 9
Markers of vulnerability in schizophrenia.
Ladea, M., & Prelipceanu, D. (2009) · PubMed Central · Cited by 9
Differential Contributions of Lateral Prefrontal Cortex Regions to Visual Memory Processes
McLaughlin, N. C. R., Moore, D. W., Fulwiler, C., Bhadelia, R. A., & Gansler, D. A. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-009-9062-7 · Cited by 9
DISC1 mRNA expression is not influenced by common Cis‐acting regulatory polymorphisms or imprinting
Hayesmoore, J. B. G., Bray, N. J., Owen, M., & O’Donovan, M. C. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30715 · Cited by 9
Association Study Between the Pericentrin (PCNT) Gene and Schizophrenia
Numata, S., Nakataki, M., Iga, J., Tanahashi, T., Nakadoi, Y., Ohi, K., Hashimoto, R., Takeda, M., Itakura, M., Ueno, S., et al. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8106-x · Cited by 9
BRAFF, D. L., Freedman, R., Schork, N. J., & Gottesman, I. I. (2008) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.6.2.foc221 · Cited by 8
Schizophrenia: Modeling a complex psychiatric disorder
Arguello, P. A., & Gogos, J. A. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.12.004 · Cited by 7
Cao, F., Zhang, H., Feng, J., Gao, C., & Li, S. (2013) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0438 · Cited by 7
Sayin, A., Yüksel, N., Konaç, E., Yılmaz, A., Doğan, B., Tönge, Ş., Şahiner, Ş. Y., & Menevşe, A. (2013) · DNA and Cell Biology · doi:10.1089/dna.2012.1894 · Cited by 7
DISC1 gene polymorphisms and the risk of schizophrenia in an Iranian population: A preliminary study
Shokouhifar, A., Askari, N., Yazdani, S., & Mehrabadi, J. F. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27427 · Cited by 7
Intermediate Phenotypes in Genetic Studies of Schizophrenia
Egan, M. F., Leboyer, M., & Weinberger, D. R. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch15 · Cited by 7
The Center for Computational Biology: resources, achievements, and challenges
Toga, A. W., Dinov, I. D., Thompson, P. M., Woods, R. P., Horn, J. D. V., Shattuck, D. W., & Parker, D. S. (2011) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000525 · Cited by 6
Self-citationGenetic Effects of DISC1 and G72 (DAOA) on Visual Learning of Patients with Schizophrenia
Chang, J. P., Huang, K.-H., Lin, C., & Lane, H. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s235675 · Cited by 6
Human Brain Volume: What’s in the Genes#
Peper, J. S., Zwiers, M. P., Boomsma, D. I., Kahn, R. S., & Pol, H. E. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-76727-7_10 · Cited by 6
Orešič, M., Seppänen-Laakso, T., Sun, D., Tang, J., Therman, S., Viehman, R., Mustonen, U., van Erp, T. G., Hyötyläinen, T., Thompson, P., et al. (2012) · Genome Medicine · doi:10.1186/gm300 · Cited by 5
Self-citationDong, Z., Sun, X., Pan, C., Lu, T., Han, Y., Wang, L., Yan, H., Dong, L., Zhang, D., & Yue, W. (2016) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000138 · Cited by 5
The Cognitive Neuroscience of Thought Disorder in Schizophrenia
Bachman, P., & Cannon, T. D. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199734689.013.0034 · Cited by 5
Self-citationVázquez-Bourgon, J., Ayesa-Arriola, R., Fatjó-Vilas, M., Roiz-Santiañez, R., Fañanás, L., & Crespo-Facorro, B. (2015) · European psychiatry · doi:10.1016/j.eurpsy.2015.07.007 · Cited by 5
Liu, C., Liu, Y.-L., Hwu, H., Fann, C. S. J., Yang, U., Hsu, P.-C., Chang, C.-C., Chen, W. J., Hwang, T., Hsieh, M. H., et al. (2019) · Journal of Human Genetics · doi:10.1038/s10038-019-0597-1 · Cited by 5
Preclinical neuroimaging of gene–environment interactions in psychiatric disease
Yi, S. Y., Barnett, B. R., & Yu, J. J. (2019) · British Journal of Radiology · doi:10.1259/bjr.20180885 · Cited by 5
Classical Genetic Studies of Schizophrenia
Riley, B., & Kendler, K. (2011) · Wiley eBooks · doi:10.1002/9781444327298.ch12 · Cited by 6
Zhang, B.-L., Chen, Y., Zhang, Y., Qiao, Y., Wu, Y., Zhang, Y., Lu, Y., You, X., Li, Y., Huang, H.-D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63747-x · Cited by 4
Huang, K.-Y., Huang, Y.-J., Chen, S.-J., Lin, C., & Lane, H. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173554 · Cited by 4
The genetics of latent inhibition: studies of inbred and mutant mice
Lipina, T. V., & Roder, J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511730184.012 · Cited by 4
Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese.
Hu, G., Yang, C., Zhao, J., Zhu, M., Guo, X., Bao, C., Si, J., Xu, A., Jie, Y., Wang, Z., et al. (2015) · PubMed Central · doi:10.11919/j.issn.1002-0829.215120 · Cited by 4
Cuoco, J. A., Esposito, A. W., Moriarty, S., Tang, Y., Seth, S., Toia, A. R., Kampton, E. B., Mayr, Y., Khan, M., Khan, M. B., et al. (2017) · The Cerebellum · doi:10.1007/s12311-017-0892-3 · Cited by 4
Chromosomal region 1q24.1 is associated with increased risk of schizophrenia in Pakistani population
Fatima, W., Riaz, S., Shahzad, M. A., Naz, Z., Mahmood, S., & Hasnain, S. (2020) · Gene · doi:10.1016/j.gene.2020.144390 · Cited by 4
Tuulio‐Henriksson, A., Perälä, J., Gottesman, I. I., & Suvisaari, J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9464-4_8 · Cited by 4
Self-citationWalters, J., O’Donovan, M. C., & Owen, M. J. (2011) · Wiley eBooks · doi:10.1002/9780470978672.ch4 · Cited by 4
Molecular Genetics of Schizophrenia: Focus on Symptom Dimensions
Ritsner, M. S., & Susser, E. (2009) · Springer eBooks · doi:10.1007/978-90-481-2298-1_4 · Cited by 4
Guardiola-Ripoll, M., Sotero-Moreno, A., Almodóvar-Payá, C., Hostalet, N., Guerrero‐Pedraza, A., Ramiro, N., Ortiz‐Gil, J., Arias, B., Madre, M., Soler‐Vidal, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10660-8 · Cited by 3
Impaired Neurogenesis as a Risk Factor for Schizophrenia and Related Mental Diseases
Osumi, N., & Guo, N. (2011) · Springer eBooks · doi:10.1007/978-4-431-53945-2_6 · Cited by 3
Kishi, T., Okochi, T., Kitajima, T., Ujike, H., Inada, T., Yamada, M., Uchimura, N., Sora, I., Iyo, M., Ozaki, N., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.06.001 · Cited by 3
Association study between schizophrenia and the DISC1 gene polymorphism.
Mohammad, F. A., Haidari, M., Galehdari, H., Pooryasin, A., Reza, K. S., Hosseini, S., & Nahid, K. M. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3
Prediction of Psychosis Through the Prodromal Syndrome
Cannon, T. D. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0913-8_13 · Cited by 3
Self-citationMolecular Genetics of Schizophrenia and Related Intermediate Phenotypes in a Founder Population
Wedenoja, J. (2010) · Työväentutkimus Vuosikirja · Cited by 3
Genes, hypoxia and schizophrenia
Cannon, T. D. (2006) · CRC Press eBooks · doi:10.1201/b14457-16 · Cited by 2
Self-citationDissecting the Molecular Causes of Schizophrenia
Wildenauer, D. B., Wildenauer, D. M. B., & Schwab, S. G. (2008) · Nucleic acids and molecular biology · doi:10.1007/978-3-540-85383-1_2 · Cited by 2
Desbonnet, L. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00016-x · Cited by 3
Genetic Studies of Schizophrenia
Riley, B. (2011) · Advances in neurobiology · doi:10.1007/978-1-4419-7197-5_13 · Cited by 4
Генетические корреляты когнитивных нарушений при шизофрении (обзор литературы)
(2018) · Сибирский вестник психиатрии и наркологии · doi:10.26617/1810-3111-2018-2(99)-105-110 · Cited by 2
The Cellular Mechanisms of Executive Functions and Working Memory
Lightbourne, T. C., & Arnsten, A. F. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803676-1.00002-7 · Cited by 1
GENETIC EPIDEMIOLOGY OF CANNABIS USE, ABUSE AND DEPENDENCE: A COMMENT ON AGRAWAL & LYNSKEY (2006)
Kaprio, J. A. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01449.x · Cited by 2
Self-citationChromosomal abnormalities and psychosis Chromosomal abnormalities and psychosis
Muir, W. J., Pickard, B. S., & Blackwood, D. (2005) · Cited by 2
Delevich, K. M., Jaaro-Peled, H., Penzo, M. A., Sawa, A., & Li, B. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/054759 · Cited by 2
Bradshaw, N. J., Ukkola-Vuoti, L., Pankakoski, M., Zheutlin, A. B., Ortega-Alonso, A., Torniainen‐Holm, M., Sinha, V., Therman, S., Paunio, T., Suvisaari, J., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/087007 · Cited by 2
Self-citationSotero-Moreno, A., Guardiola-Ripoll, M., Hostalet, N., Moreira, M., Giralt-López, M., Almodóvar-Payá, C., Campanera, S., Muñoz, M., Martín, M., Chaumette, B., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116721 · Cited by 2
Abazyan, S., & Pletnikov, M. V. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.017 · Cited by 1
Neurocognition and schizophrenia
Sachs, G. (2009) · CRC Press eBooks · doi:10.3109/9781420080063-9 · Cited by 1
Endophenotypes in schizophrenia
Freedman, R. (2017) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(17)30986-0 · Cited by 1
Neuroimaging Biomarkers in Schizophrenia
Tost, H., & Meyer‐Lindenberg, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_11 · Cited by 1
Recombination Hot-Spots and Defense Players – Maintenance of Genomic Integrity
Kamdar, R. P., & Basuthkar, J. (2013) · InTech eBooks · doi:10.5772/54016 · Cited by 1
Sinha, V., Ortega‐Alonso, A., Ukkola‐Vuoti, L., Mantere, O., Zheutlin, A. B., Torniainen‐Holm, M., Therman, S., Tuulio‐Henriksson, A., Jylhä, P. J., Kaprio, J. A., et al. (2020) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgaa055 · Cited by 1
Self-citationGenetics of Schizophrenia: The 1q42 Locus in Finnish Families
Hennah, W. (2005) · Työväentutkimus Vuosikirja · Cited by 1
Self-citationCommon Gene Variants in Schizophrenia Susceptibility with Focus on Neurodevelopment
Kähler, A. K. (2009) · NORA - Norwegian Open Research Archives · Cited by 1
A System-level Brain Model of Spatial Working Memory
Bond, A. H. (2006) · eScholarship (California Digital Library) · Cited by 1
Metadata
- Authors
- Cannon, T. D., Hennah, W., van Erp, T. G. M., Thompson, P. M., Lonnqvist, J., Huttunen, M., Gasperoni, T., Tuulio-Henriksson, A., Pirkola, T., Toga, A. W., Kaprio, J., Mazziotta, J., & Peltonen, L.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2005-11-01
- Volume
- 62
- Issue
- 11
- Pages
- 1205
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2117644711
- Cited by
- 337
- References
- 64
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 19 · 2014: 8 · 2013: 14 · 2012: 24
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-52857, R01MH052857)
- National Institute of Biomedical Imaging and Bioengineering (R21EB001561, EB01561)
- National Center for Research Resources (P41RR013642, R21RR019771, RR 13642, RR 19771, RR00827, M01RR000827)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, DISC1, TRAX, haplotype association, genetic susceptibility, short-term memory, long-term memory, hippocampal volume, endophenotypes, monozygotic twins, dizygotic twins, single nucleotide polymorphisms, brain structure, synaptogenesis
- MeSH terms
- Atrophy, Diseases in Twins, DNA-Binding Proteins, Female, Finland, Haplotypes, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Nerve Tissue Proteins, Neuropsychological Tests, Phenotype, Risk Factors, Schizophrenia, Twins, Dizygotic, Twins, Monozygotic, Cohort Studies, Prefrontal Cortex, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review