Cited by 169Schizophrenia research and treatmentMetabolomics and Mass Spectrometry StudiesFatty Acid Research and Health

Phospholipids and Insulin Resistance in Psychosis: A Lipidomics Study of Twin Pairs Discordant for Schizophrenia

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Orešič, Matej, Seppänen-Laakso, Tuulikki, Sun, Daqiang, Tang, Jing, Therman, Sebastian, Viehman, Rachael, Mustonen, Ulla, van Erp, Theo G +8 more·2012·Genome Medicine

Abstract

BACKGROUND: Several theories have been proposed to conceptualize the pathological processes inherent to schizophrenia. The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission. METHODS: Here we sought to determine the lipidomic profiles associated with schizophrenia in twin pairs discordant for schizophrenia as well as unaffected twin pairs. The study included serum samples from 19 twin pairs discordant for schizophrenia (mean age 51 ± 10 years; 7 monozygotic pairs; 13 female pairs) and 34 age and gender matched healthy twins as controls. Neurocognitive assessment data and gray matter density measurements taken from high-resolution magnetic resonance images were also obtained. A lipidomics platform using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry was applied for the analysis of serum samples. RESULTS: In comparison to their healthy co-twins, the patients had elevated triglycerides and were more insulin resistant. They had diminished lysophosphatidylcholine levels, which associated with decreased cognitive speed. CONCLUSIONS: Our findings may be of pathophysiological relevance since lysophosphatidylcholines, byproducts of phospholipase A2-catalyzed phospholipid hydrolysis, are preferred carriers of polyunsaturated fatty acids across the blood-brain barrier. Furthermore, diminishment of lysophosphatidylcholines suggests that subjects at risk of schizophrenia may be more susceptible to infections. Their association with cognitive speed supports the view that altered neurotransmission in schizophrenia may be in part mediated by reactive lipids such as prostaglandins.

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  • Nine studies evaluated broad panels of different lipid markers in patients with SCZ and detected statistical differences in fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.

    “Nine studies evaluated the broad panels of different lipid markers in patients with SCZ [31,34,40,41,42,43,44,45,46] and detected statistical differences in the following lipid classes: fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.”

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Research works printed but not linked: 1

  1. Suvisaari JM Saarni SI Perala J Suvisaari JV Harkanen T Lonnqvist J Reunanen A Metabolic syndrome among persons with schizophrenia and other psychotic disorders in a general population survey. J Clin Psychiatry 2007 68 1045 1055 10.4088/JCP.v68n0711 17685741 · DOI

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Authors
Orešič, M., Seppänen-Laakso, T., Sun, D., Tang, J., Therman, S., Viehman, R., Mustonen, U., van Erp, T. G., Hyötyläinen, T., Thompson, P., Toga, A. W., Huttunen, M. O., Suvisaari, J., Kaprio, J., Lönnqvist, J., & Cannon, T. D.
Affiliations
  • VTT Technical Research Centre of Finland (FI)
  • University of California, Los Angeles (US)
  • Finnish Institute for Health and Welfare (FI)
  • University of Helsinki (FI)
  • Helsinki University Hospital (FI)
Corresponding author
Orešič, Matej
Venue
Genome Medicine
Published
2012-01-18
Volume
4
Issue
1
Pages
1-1
ISSN
1756-994X (ISSN-L)
OpenAlex
W1272423043
Cited by
5
References
45
Citations by year
2024: 1 · 2020: 3 · 2018: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Genome Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • European Commission (222720)
  • Academy of Finland
  • FP7 Food, Agriculture and Fisheries, Biotechnology
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
schizophrenia, insulin resistance, phospholipids, lysophosphatidylcholine, serum lipidomics, twin discordance, triglycerides, cognitive speed, phospholipase A2, polyunsaturated fatty acids, blood-brain barrier, gray matter density, neurocognitive function

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