The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Amygdala and Ventrolateral Prefrontal Cortex Function During Anticipated Peer Evaluation in Pediatric Social Anxiety
Open accessAbstract
CONTEXT: Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. OBJECTIVE: To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. DESIGN: Case-control study. SETTING: Government clinical research institute. PARTICIPANTS: Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. MAIN OUTCOME MEASURES: Blood oxygenation level-dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants' ratings of specific peers. RESULTS: Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. CONCLUSIONS: Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Socially anxious adolescents also show greater amygdala activation when anticipating evaluation from undesired peers [33]”
From The social motivation theory of autism (2012) · cites this paper as [33]
In the citing paper
“Anxious adolescents showed increased activation in the amygdala and vmPFC when rating how much the other adolescents would want to chat with them; interestingly, activation was increased only when viewing the adolescents that the subjects had previously rated as low desirability.”
From Neural Substrates of Childhood Anxiety Disorders (2012) · cites this paper as [135]
In the citing paper
“Finally, work that leveraged the very social context that elicits fear in SAD has shown amygdala hyperactivation in socially anxious versus healthy adolescents when anticipating being evaluated by unknown peers with whom participants expressed disinterest for a social interaction (Guyer et al., 2008).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Guyer et al., 2008
In the citing paper
“Interestingly, in the study of social evaluation anticipation, positive functional connectivity between the vlPFC and amygdala was found in socially anxious versus healthy adolescents when anticipating evaluation from undesirable peers, suggesting a possible role for the vlPFC in modulating avoidance of stimuli associated with the threat of social retaliation (Guyer et al., 2008).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Guyer et al., 2008
In the citing paper
“As flexible social behavior is critical for competently interacting with others and adapting to social contexts, perturbations in the function of the vlPFC, in particular, relate to psychopathology in adolescence, such as social anxiety disorder (Guyer et al., 2008, Monk et al., 2006, Monk et al., 2008).”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Guyer et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
A Children's Global Assessment Scale (CGAS)
Shaffer, D. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790100074010 · Cited by 3,716
Steinberg, L., & Morris, A. (2001) · Journal of Cognitive Education and Psychology · doi:10.1891/194589501787383444 · Cited by 3,693
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
A cognitive-behavioral model of anxiety in social phobia
Rapee, R. M., & Heimberg, R. G. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)00022-3 · Cited by 2,987
BIRMAHER, B., KHETARPAL, S., BRENT, D., CULLY, M., BALACH, L., KAUFMAN, J., & NEER, S. M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199704000-00018 · Cited by 2,846
Flagged first, then by citations
Research works printed but not linked: 1
- [38]Talairach J Tournoux P Co-planar Stereotaxic Altas of the Human Brain Stuttgart, Germany Georg Thieme Verlag 1988
Cited by
Sorted by citations
Items 301–370 of 370
Neurobiology of Paediatric Anxiety
Zantvoord, J. B., Lindauer, R., Bakker, M. J., & Boer, F. (2012) · Wiley eBooks · doi:10.1002/9781118315088.ch5 · Cited by 2
The Social Neuroscience of Social Anxiety Disorder
Syal, S., & Stein, D. J. (2014) · Wiley eBooks · doi:10.1002/9781118653920.ch4 · Cited by 2
Rosa, L. A. (2018) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2018.1527217 · Cited by 1
The Neural Basis of Social Evaluation in Adolescents with Non-Suicidal Self-Injury
Cullen, K. R., Schreiner, M. W., & Klimes‐Dougan, B. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.08.002 · Cited by 1
Neural response to social feedback and internalizing dimensions
Barkley, S. B., & Nelson, B. D. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01317-w · Cited by 1
Cengiz, Ş. N. K., Güney, E., Özaslan, A., & Sarıpınar, E. G. (2025) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-025-00968-4 · Cited by 6
Ayomen, E. N., Keil, A., & Mathews, C. A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106446 · Cited by 2
Song, Y., Wu, Y., Zhou, Y., Wang, Y., Zhang, P., & Zheng, X. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121745 · Cited by 1
Neural sensitivity to social feedback and adaptations to changing social contexts in adolescence
Davis, M. M., Achterberg, M., & Sheridan, M. A. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106620 · Cited by 1
Facial Expression Recognition and Interpretation in Shy Children
Kokin, J. (2015) · doi:10.20381/ruor-2777 · Cited by 1
Hjärnan formas av psykologisk behandling
Månsson, K. N. T. (2016) · Linköping studies in behavioural science · doi:10.3384/diss.diva-132637 · Cited by 1
Galván, A., & Peris, T. S. (2020) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20200025 · Cited by 1
Comorbilidad del Trastorno Negativista Desafiante y los Trastornos de Ansiedad en preescolares
Martín‐Romera, V. (2016) · TDX (Tesis Doctorals en Xarxa) · Cited by 1
Neuropsychological Considerations in Child and Adolescent Anxiety
Larson, M. J., South, M., & Merkley, T. L. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7784-7_6 · Cited by 1
Ruggieri, V. L. (2014) · Revista de Neurología · doi:10.33588/rn.58s01.2013571 · Cited by 2
Why mind feels pain: Current status of studies on ostracism from social neuroscience
Onoda, K. (2010) · Japanese Journal of Physiological Psychology and Psychophysiology · doi:10.5674/jjppp.28.29 · Cited by 1
Neurobiology of Early-onset Anxiety Disorders
Nooner, K. B., Roy, A. K., & Pine, D. S. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780195398212.003.0010 · Cited by 1
Self-citationCrawford, B., Muhlert, N., MacDonald, G., & Lawrence, A. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.03.916999 · Cited by 2
Functional Connectivity MR Imaging
Hampson, M., Shen, X., & Constable, R. T. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1995-6_6 · Cited by 1
Vallorani, A., McNaughton, K. A., Lytle, M. N., Hallquist, M. N., Redcay, E., & Pérez‐Edgar, K. E. (2024) · doi:10.31234/osf.io/z5ebw · Cited by 1
Tone, E. B., Nawa, N. E., Nelson, E. E., Detloff, A. M., Fromm, S. J., Pine, D. S., & Ernst, M. (2011) · Developmental Neuropsychology · doi:10.1080/87565641.2010.549876 · Cited by 25
Self-citationSargent, K. (2022) · Digital Archive @ GSU · doi:10.57709/7282109
Anxiety and Emotion Regulation
Lebowitz, E. R., & Omer, H. (2013) · doi:10.1002/9781118589366.ch2
Nees, F., & Flor, H. (2014) · Wiley eBooks · doi:10.1002/9781118775349.ch15
Anxiety and depression in young people: developmental considerations
Lau, J. Y. F., Hilbert, K., & Gregory, A. M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139344456.004
Self-citationMauseth, T. A. (2013) · Texas ScholarWorks (Texas Digital Library)
Fonzo, G. A. (2013) · eScholarship (California Digital Library)
Understanding and treating social anxiety: lessons learnt from developmental cognitive neuroscience
Lau, J. Y. F. (2013) · Neuropsychiatry · doi:10.2217/npy.13.73
Self-citationKeshavan, M. S., Medical, B. I. D., & Lau, J. Y. F. (2014)
Self-citationSwartz, J. R. (2013) · Deep Blue (University of Michigan)
The affective neuroscience of human social anxiety
Miskovic, V., & Schmidt, L. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139012850.011
Influences on cognition : emotion, social cues, context
Brennan-Craddock, A. (2016) · Bangor University Research Portal (Bangor University)
Review of Brain Imaging Studies of Social Anxiety Disorder
Yokoyama, C., Kaiya, H., Tanii, H., & Kumano, H. (2015) · Anxiety Disorder Research · doi:10.14389/jsad.7.1_52
Etiological Factors: Basic Neuroscience
Cohodes, E. M., & Gee, D. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813004-9.00004-9 · Cited by 1
Amygdala Basal Activity Differs in Hospitalized Pediatric Psychiatry Patients Compared to Control
Bernal, B., Bohannon, D., Gonzalez, J., Altman, N. R., & Padilla, A. F. (2018) · Radiology - Open Journal · doi:10.17140/roj-3-120
The Social Cost of Pain: Rejection Sensitivity, Social Rejection, and Cannabis Use in Young Adults
Dambreville, N. (2019) · CUNY Academic Works (City University of New York)
Risk profiles for adolescent internalizing problems
Hudson, K. E. (2019) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Neuroendocrinology and Neuroimaging Studies of Social Anxiety Disorder
Phan, K. L., & Klumpp, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-394427-6.00012-1
Majeed, A. (2019) · Pakistan Journal of Education · doi:10.30971/pje.v36i2.395
Examining Patterns of Executive Functioning Across Dimensions of Psychopathology
Roye, S. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5347
Beligeanu, M. (2021) · Studia Doctoralia · doi:10.47040/sdpsych.v12i2.131
Neuroscientific Approaches to the Study of Self and Social Emotion Regulation During Development
Leal, A. S. M., & Silvers, J. A. (2022) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780198855903.013.7 · Cited by 2
Witte, N. A. J. D., Mueller, S. C., & Cromheeke, S. (2018) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/jxaqc
Volman, I., den Ouden, H. E. M., & Roelofs, K. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0010
Angststörungen im Kindes- und Jugendalter
In‐Albon, T. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-49289-5_105-1
Birk, S. L., Mennies, R. J., Guerra-Guzman, K., Aunapu, D., & Olino, T. M. (2023) · Journal of Emotion and Psychopathology · doi:10.55913/joep.v1i1.8
Jeung-Maarse, H. (2023) · Research Publications (Maastricht University) · doi:10.26481/dis.20230918hj
Neoh, M. J. Y. (2024) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/174933
Gerrans, P. (2024) · Oxford University Press eBooks · doi:10.1093/9780191994395.003.0008
Angststörungen im Kindes- und Jugendalter
In‐Albon, T. (2024) · Springer Reference Medizin · doi:10.1007/978-3-662-66744-6_105
Jones, E., & Rozenman, M. S. (2024) · Journal of Media Psychology Theories Methods and Applications · doi:10.1027/1864-1105/a000450
Leiva, I., Reisman, S. S., Helion, C., Murty, V. P., & Jarcho, J. M. (2025) · Journal of Mood and Anxiety Disorders · doi:10.1016/j.xjmad.2025.100105
Geng, L., Feng, Q., Wang, X., Li, Y., & Qiu, J. (2025) · Brain and Cognition · doi:10.1016/j.bandc.2025.106352
Goldberg, E. L., Brock, R. L., Yaroch, A. L., Hill, J. L., Mason, W. A., Nelson, J. M., Espy, K. A., & Nelson, T. D. (2025) · Appetite · doi:10.1016/j.appet.2025.108277
Endocannabinoids and the neurobiology of emotional states
Petrie, G. N., Lunge, A. R., Mayo, L. M., & Hill, M. N. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00021-9
Díaz, D. E., Norman, L. J., Block, S. R., Iturra-Mena, A. M., Phan, K. L., Monk, C. S., & Fitzgerald, K. D. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.12.005
Associations between amygdala connectivity and experienced discrimination in childrenPreprint
Goode, N. J., Potter, E., Rasheed, M., Camacho, M., Higashi, R., Nguyen, L., Shah, S., Miranda-Domínguez, Ó., Hermosillo, R. J. M., Juliano, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.695992
Implicitly tuned: The neural effects of social feedback on adolescent learning
Bosseler, A. N., Peterson, E. R., Stavropoulos, K. K. M., Mizrahi, J. C., Larson, E., Corrigan, N. M., Taulu, S., Meltzoff, A. N., & Kuhl, P. K. (2026) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2026.101809
Jacoby, K., Przeworski, A., & Rose, A. M. (2026) · Child & Family Behavior Therapy · doi:10.1080/07317107.2026.2637447
Neural responses to error in youth: the impact of social context, anxiety, and worry
Khosravi, P., Poe, A. D., Malone, E. P., Bezek, J. L., Meyer, M., Siegal, O., Cardinale, E. M., Kircanski, K., Brotman, M. A., Haller, S. P., et al. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-025-02957-6
Self-citationDeng, G., Zhou, Z., Song, K., Ai, H., Zhang, J., Nan, Y., & Xu, P. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.03.002 · Cited by 1
Distinct Cortical Activation in Adolescents With Social Anxiety Disorder: An fNIRS Study
Liu, H., Zhang, J.-R., Niu, Y., Huang, W.-H., Li, Q.-Q., Liu, Z.-F., Leavey, G., & Li, G.-Z. (2026) · Brain and Behavior · doi:10.1002/brb3.71357
Arrington, M. N., Swartz, J. R., Fine, J., & Guyer, A. E. (2026) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2026.101774
Self-citationEvaluation of the Results of a Multicomponent Emotional Health Intervention in a School Setting
Barroso-Márquez, E.-M., Merino-Godoy, M.-D.-L.-Á., Eraña-Méndez, I., Gómez-Asencio, D., Cabrera-Arana, Y., Arana-Álvarez, C., Gago-Valiente, F.-J., & Carrasco-Barroso, E.-M. (2026) · European Journal of Investigation in Health Psychology and Education · doi:10.3390/ejihpe16070102
Vallorani, A., McNaughton, K. A., Lytle, M. N., Hallquist, M. N., Redcay, E., & Pérez‐Edgar, K. E. (2026) · doi:10.31234/osf.io/z5ebw_v2
Rappaport, B. I., Glazer, J. E., Letkiewicz, A. M., Li, L. Y., McGregor, M. M., Sarkas, S. E., Sritharan, A., Massac, L. A., Durham, K., Auerbach, R. P., et al. (2026) · Development and Psychopathology · doi:10.1017/s0954579426101722
Hatchard, T., Boyd, J. E., Mutschler, C., Hewitt, J., Scott, A. M., Ip, J., Rowa, K., Syan, S. K., Elcock, A., & McCabe, R. E. (2026) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x26100749
Differential effects of central oxytocin on social versus cued fear in male rodents
Toth, I. (2014) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.27841
Metadata
- Authors
- Guyer, A. E., Lau, J. Y. F., McClure-Tone, E. B., Parrish, J., Shiffrin, N. D., Reynolds, R. C., Chen, G., Blair, R. J. R., Leibenluft, E., Fox, N. A., Ernst, M., Pine, D. S., & Nelson, E. E.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2008-11-03
- Volume
- 65
- Issue
- 11
- Pages
- 1303
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC2717208
- OpenAlex
- W2119671456
- Cited by
- 371
- References
- 60
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 25 · 2019: 22 · 2018: 19 · 2017: 19 · 2016: 31 · 2015: 23 · 2014: 34 · 2013: 39 · 2012: 21
- FWCI
- 24.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Archive @ GSU (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002781, R00MH080076, R29MH057503, K99 MH080076)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- amygdala, ventrolateral prefrontal cortex, peer assessment, adolescents, fear circuitry
- MeSH terms
- Adolescent, Amygdala, Anxiety Disorders, Child, Culture, Facial Expression, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Pattern Recognition, Visual, Peer Group, Phobic Disorders, Social Perception, Case-Control Studies, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
