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AN OVARIAN HORMONE: PRELIMINARY REPORT ON ITS LOCALIZATION, EXTRACTION AND PARTIAL PURIFICATION, AND ACTION IN TEST ANIMALS
Abstract
The fact that double ovariectomy abolishes the cyclic changes which normally occur in the genital tract of female mammals demonstrates that these changes are due to some influence from the ovaries. That this influence is hormonal in nature is indicated by the maintenance of cyclic changes by autotransplantation of the ovaries to other sites in the body.1Many attempts have been made to localize the seat of production of an internal secretion in definite ovarian structures. The follicles, the corpora lutea2developing in them after ovulation, and the interstitial tissue3have all been cited as possible sources, and many different ovarian preparations have been used clinically in the belief that therapeutic effects were being secured from accompanying hormones. But there appears to be no conclusive evidence of either a definite localization of the hypothetic hormone or of the specific effect claimed for the commercial ovarian extracts in
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Cited by
Esplugas, S., Bila, D. M., Krause, L. G. T., & Dezotti, M. (2007) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2007.07.073 · Cited by 1,020
An updated review of environmental estrogen and androgen mimics and antagonists
Sonnenschein, C., & Soto, A. M. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00027-2 · Cited by 990
Goldman, J. M., Murr, A. S., & Cooper, R. L. (2007) · Birth Defects Research Part B: Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20106 · Cited by 801
The G protein-coupled oestrogen receptor GPER in health and disease: an update
Prossnitz, E. R., & Barton, M. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00822-7 · Cited by 231
Metadata
- Authors
- ALLEN, E., & DOISY, E. A.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1923-09-08
- Volume
- 81
- Issue
- 10
- Pages
- 819
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W4252199431
- Cited by
- 479
- References
- 0
- FWCI
- 56.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: AN OVARIAN HORMONE: PRELIMINARY REPORT ON ITS LOCALIZATION, EXTRACTION AND PARTIAL PURIFICATION, AND ACTION IN TEST ANIMALS. https://app.cochat.ai/papers/10.1001/jama.1923.02650100027012
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- ALLEN, E., & DOISY, E. A. (1923). AN OVARIAN HORMONE: PRELIMINARY REPORT ON ITS LOCALIZATION, EXTRACTION AND PARTIAL PURIFICATION, AND ACTION IN TEST ANIMALS. Journal of the American Medical Association. https://doi.org/10.1001/jama.1923.02650100027012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
