The G protein-coupled oestrogen receptor GPER in health and disease: an update

Sex differences in immune responses

Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370 · see citing works

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,792 · see citing works

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585 · see citing works

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302 · see citing works

ERβ: Identification and characterization of a novel human estrogen receptor

Mosselman, S., Polman, J., & Dijkema, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00782-x · Cited by 2,269 · see citing works

Sex and gender: modifiers of health, disease, and medicine

Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001 · see citing works

Rate of Pregnancy-Related Relapse in Multiple Sclerosis

Confavreux, C., Hutchinson, M., Hours, M. M., Cortinovis-Tourniaire, P., & Moreau, T. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390501 · Cited by 1,559 · see citing works

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Daub, H., Weiß, F. U., Wallasch, C., & Ullrich, A. (1996) · Nature · doi:10.1038/379557a0 · Cited by 1,476 · see citing works

Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410 · see citing works

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387 · see citing works

The role of estrogens in control of energy balance and glucose homeostasis

Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works

A two-step mechanism for the interaction of estradiol with rat uterus.

Jensen, E. V., Suzuki, T., Kawashima, T., Stumpf, W. E., Jungblut, P. W., & DeSombre, E. R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.59.2.632 · Cited by 1,015 · see citing works

The G-protein-coupled estrogen receptor GPER in health and disease

Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925 · cited 1× · see citing works

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

Filardo, E. J., Quinn, J. A., Frackelton, A. R., & Bland, K. I. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.1.0758 · Cited by 907 · see citing works

Tamoxifen: a most unlikely pioneering medicine

Jordan, V. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1031 · Cited by 832 · see citing works

Virtual and biomolecular screening converge on a selective agonist for GPR30

Bologa, C., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., Parker, M. A., Tkachenko, S. E., Savchuk, N., Sklar, L. A., et al. (2006) · Nature Chemical Biology · doi:10.1038/nchembio775 · Cited by 819 · see citing works

Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

Stauffer, S. R., Coletta, C. J., Tedesco, R., Nishiguchi, G., Carlson, K. E., Sun, J., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000170m · Cited by 760 · see citing works

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Paterni, I., Granchi, C., Katzenellenbogen, J. A., & Minutolo, F. (2014) · Steroids · doi:10.1016/j.steroids.2014.06.012 · Cited by 736 · see citing works

Cloning of the human estrogen receptor cDNA.

Walter, P., Green, S., Greene, G. L., Krust, A., Bornert, J., Jeltsch, J., Staub, A., Jensen, E. Ø., Scrace, G., & Waterfield, M. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7889 · Cited by 731 · see citing works

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

Toft, D. O., & Górski, J. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.55.6.1574 · Cited by 682 · see citing works

Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

Meyers, M. J., Sun, J., Carlson, K. E., Marriner, G. A., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010254a · Cited by 678 · see citing works

Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption

Thomas, P., & Dong, J. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.017 · Cited by 604 · see citing works

Identification of a Gene (GPR30) with Homology to the G-Protein-Coupled Receptor Superfamily Associated with Estrogen Receptor Expression in Breast Cancer

Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U., & Weigel, R. J. (1997) · Genomics · doi:10.1006/geno.1997.4972 · Cited by 590 · see citing works

In vivo effects of a GPR30 antagonist

Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., Bologa, C., Leitão, A., Brailoiu, E., Deliu, E., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.168 · Cited by 533 · see citing works

Guide to Receptors and Channels (GRAC), 3rd edition

Alexander, S. P. H., Mathie, A. A., & Peters, J. A. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707746 · Cited by 510 · see citing works

Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice

May, C. L., Chu, K., Hu, M., Ortega, C. S., Simpson, E. R., Korach, K. S., Tsai, M., & Mauvais‐Jarvis, F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602956103 · Cited by 500 · see citing works

AN OVARIAN HORMONE

Allen, E., & Doisy, E. A. (1923) · JAMA · doi:10.1001/jama.1923.02650100027012 · Cited by 479 · see citing works

The estrogen receptor: a model for molecular medicine.

Jensen, E. V., & Jordan, V. C. (2003) · PubMed · Cited by 470 · see citing works

The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17β-Estradiol and Phytoestrogens in Breast Cancer Cells

Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A. G., Sisci, D., Pezzi, V., Montanaro, D., Musti, A. M., Picard, D., & Andò, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403588200 · Cited by 448 · see citing works

Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice

Mårtensson, U. E. A., Salehi, A. A., Windahl, S. H., Gomez, M. F., Swärd, K., Daszkiewicz-Nilsson, J., Wendt, A., Andersson, N., Hellstrand, P., Grände, P., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0623 · Cited by 413 · see citing works

Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen.

Szego, C. M., & Davis, J. S. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.4.1711 · Cited by 406 · see citing works

G Protein–Coupled Receptor 30 (GPR30) Mediates Gene Expression Changes and Growth Response to 17β-Estradiol and Selective GPR30 Ligand G-1 in Ovarian Cancer Cells

Albanito, L., Madeo, A., Lappano, R., Vivacqua, A., Rago, V., Carpino, A., Oprea, T. I., Prossnitz, E. R., Musti, A. M., Andò, S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2909 · Cited by 399 · see citing works

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity

Haas, E., Bhattacharya, I., Brailoiu, E., Damjanović, M., Brailoiu, G. C., Gao, X., Mueller-Guerre, L., Marjon, N. A., Gut, A., Minotti, R., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.190892 · Cited by 373 · see citing works

Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression

Filardo, E. J., Graeber, C. T., Quinn, J. A., Resnick, M. B., Giri, D. D., DeLellis, R. A., Steinhoff, M. M., & Sabo, E. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0860 · Cited by 361 · see citing works

Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

Stubbins, R., Holcomb, V. B., Hong, J., & Núñez, N. P. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0266-4 · Cited by 345 · see citing works

The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

Vivacqua, A., Bonofiglio, D., Recchia, A., Musti, A., Picard, D., Andò, S., & Maggiolini, M. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0280 · Cited by 345 · see citing works

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

Divella, R., Luca, R. D., Abbate, I., Naglieri, E., & Daniele, A. (2016) · Journal of Cancer · doi:10.7150/jca.16884 · Cited by 342 · see citing works

Discovery of Three Novel G-Protein-Coupled Receptor Genes

O’Dowd, B. F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K. R., Heng, H. H., Kolakowski, L. F., & George, S. R. (1998) · Genomics · doi:10.1006/geno.1998.5095 · Cited by 335 · see citing works

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors

Meyer, M. R., Clegg, D. J., Prossnitz, E. R., & Barton, M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02237.x · Cited by 331 · see citing works

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

Pandey, D. P., Lappano, R., Albanito, L., Madeo, A., Maggiolini, M., & Picard, D. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.304 · Cited by 327 · see citing works

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

Dennis, M. K., Field, A. S., Burai, R., Ramesh, C., Petrie, W. K., Bologa, C., Oprea, T. I., Yamaguchi, Y., Hayashi, S., Sklar, L. A., et al. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.07.002 · Cited by 312 · see citing works

Estrogen Receptor Signaling in the Immune System

Chakraborty, B., Byemerwa, J. K., Krebs, T., Lim, F., Chang, C., & McDonnell, D. P. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac017 · Cited by 275 · see citing works

Endometrial cell calcium and oestrogen action

Pietras, R. J., & Szego, C. M. (1975) · Nature · doi:10.1038/253357a0 · Cited by 266 · see citing works

International Union of Basic and Clinical Pharmacology. XCVII. G Protein–Coupled Estrogen Receptor and Its Pharmacologic Modulators

Prossnitz, E. R., & Arterburn, J. B. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009712 · Cited by 263 · see citing works

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives

Barton, M., Filardo, E. J., Lolait, S. J., Thomas, P., Maggiolini, M., & Prossnitz, E. R. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.021 · Cited by 249 · see citing works

The G Protein–Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor–Positive Breast Cancer Cells

Ariazi, E. A., Brailoiu, E., Yerrum, S., Shupp, H. A., Slifker, M. J., Cunliffe, H. E., Black, M. A., Donato, A. L., Arterburn, J. B., Oprea, T. I., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3068 · Cited by 236 · see citing works

A NON-STEROIDAL ESTROGEN ANTAGONIST l-(p-2-DIETHYLAMINOETHOXYPHENYLH-PHENYL-2-p-METHOXYPHENYL ETHANOL

Lerner, L. J., HOLTHAUS, F. J., & THOMPSON, C. R. (1958) · Endocrinology · doi:10.1210/endo-63-3-295 · Cited by 233 · see citing works

Estrogen regulates Hippo signaling via GPER in breast cancer

Zhou, X., Wang, S., Wang, Z., Feng, X., Liu, P., Lv, X.-B., Li, F., Yu, F.-X., Sun, Y., Yuan, H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79573 · Cited by 232 · see citing works

Cloning of Human cDNA Encoding a Novel Heptahelix Receptor Expressed in Burkitt's Lymphoma and Widely Distributed in Brain and Peripheral Tissues

Owman, C., Blay, P., Nilsson, C., & Lolait, S. J. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1654 · Cited by 224 · see citing works

The effect of conjugated equine oestrogen on diabetes incidence: the Women’s Health Initiative randomised trial

Bonds, D. E., Lasser, N. L., Qi, L., Brzyski, R. G., Caan, B. J., HEISS, G. M., Limacher, M. C., LIU, J. H., Mason, E. D., Oberman, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0096-0 · Cited by 214 · see citing works

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G2 cell-cycle arrest

Chan, Q. K. Y., Lam, H. C. M., Ng, C., Lee, A., Chan, E. S. Y., Ng, H., Ho, S., & Lau, K.-M. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.20 · Cited by 211 · see citing works

A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)

Lafferty, A. R. A., Torpy, D. J., Stowasser, M., Taymans, S. E., Lin, J. P., Huggard, P., Gordon, R. D., & Stratakis, C. A. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.11.831 · Cited by 211 · see citing works

Cloning of cDNAs Encoding G Protein-Coupled Receptor Expressed in Human Endothelial Cells Exposed to Fluid Shear Stress

Takada, Y., Kato, C., Kondo, S., Korenaga, R., & Ando, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7734 · Cited by 210 · see citing works

GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state

Sharma, G., Hu, C., Brigman, J. L., Zhu, G., Hathaway, H. J., & Prossnitz, E. R. (2013) · Endocrinology · doi:10.1210/en.2013-1357 · Cited by 210 · see citing works

GPR30 predicts poor survival for ovarian cancer

Smith, H. O., Arias‐Pulido, H., Kuo, D. Y., Howard, T. A., Qualls, C., Lee, S. J., Verschraegen, C. F., Hathaway, H. J., Joste, N. E., & Prossnitz, E. R. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.05.015 · Cited by 206 · see citing works

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

Zhang, Z., Qin, P., Deng, Y., Ma, Z., Guo, H., Guo, H., Hou, Y., Wang, S., Zou, W., Sun, Y., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1246-x · Cited by 201 · see citing works

Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

Liu, S., May, C. L., Wong, W. P. S., Ward, R. D., Clegg, D. J., Marcelli, M., Korach, K. S., & Mauvais‐Jarvis, F. (2009) · Diabetes · doi:10.2337/db09-0257 · Cited by 198 · see citing works

A novel estrogen receptor gper inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury

Bopassa, J. C., Eghbali, M., Toro, L., & Stefani, E. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00588.2009 · Cited by 197 · see citing works

Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1

Pelekanou, V., Kampa, M., Kiagiadaki, F., Deli, A., Theodoropoulos, P., Agrogiannis, G., Patsouris, E., Tsapis, A., Castanas, E., & Notas, G. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0914-430rr · Cited by 184 · see citing works

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis

Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks‐Miller, M., Mahmoudi, M., Dennis, M. K., Prossnitz, E. R., Karpus, W. J., & Horuk, R. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.023 · Cited by 181 · see citing works

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17β-Estradiol–Induced Gene Expression and Migration in Breast Cancer–Associated Fibroblasts

Madeo, A., & Maggiolini, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0408 · Cited by 179 · see citing works

Estrogen receptors in uterine plasma membrane

Pietras, R. J., & Szego, C. M. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90124-9 · Cited by 177 · see citing works

G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer

Ignatov, A., Ignatov, T., Weißenborn, C., Eggemann, H., Bischoff, J., Semczuk, A., Roessner, A., Costa, S. D., & Kalinski, T. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1584-1 · Cited by 172 · see citing works

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells

Ignatov, A., Ignatov, T., Roessner, A., Costa, S. D., & Kalinski, T. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0624-6 · Cited by 168 · see citing works

G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth

Petrie, W. K., Dennis, M. K., Hu, C., Dai, D. D., Arterburn, J. B., Smith, H. O., Hathaway, H. J., & Prossnitz, E. R. (2013) · Obstetrics and Gynecology International · doi:10.1155/2013/472720 · Cited by 166 · see citing works

Differential Effects of 17β-Estradiol on Function and Expression of Estrogen Receptor α, Estrogen Receptor β, and GPR30 in Arteries and Veins of Patients With Atherosclerosis

Haas, E., Meyer, M. R., Schurr, U. P., Bhattacharya, I., Minotti, R., Nguyen, H. H., Heigl, A., Lachat, M. L., Genoni, M., & Barton, M. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.089995 · Cited by 165 · see citing works

New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation

Wang, H. H., Liu, M., Clegg, D. J., Portincasa, P., & Wang, D. Q. ‐. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.06.006 · Cited by 160 · see citing works

Estrogen Rescues Preexisting Severe Pulmonary Hypertension in Rats

Umar, S., Iorga, A., Matori, H., Nadadur, R. D., Li, J., Maltese, F., van der Laarse, A., & Eghbali, M. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0078oc · Cited by 159 · see citing works

What have we learned about GPER function in physiology and disease from knockout mice

Prossnitz, E. R., & Hathaway, H. J. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.014 · Cited by 157 · see citing works

G Protein-coupled Estrogen Receptor Protects from Atherosclerosis

Meyer, M. R., Fredette, N. C., Howard, T. A., Hu, C., Ramesh, C., Daniel, C., Amann, K., Arterburn, J. B., Barton, M., & Prossnitz, E. R. (2014) · Scientific Reports · doi:10.1038/srep07564 · Cited by 156 · see citing works

Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

Natale, C. A., Li, J., Zhang, J., Dahal, A., Dentchev, T., Stanger, B. Z., & Ridky, T. W. (2018) · eLife · doi:10.7554/elife.31770 · Cited by 152 · see citing works

�ber ?Progynon? ein krystallisiertes weibliches Sexualhormon

Butenandt, A. (1929) · Die Naturwissenschaften · doi:10.1007/bf01506919 · Cited by 149 · see citing works

Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1

Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Proctor, T., Vandenbark, A. A., & Offner, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803205 · Cited by 148 · see citing works

Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo

Hutchens, M. P., Fujiyoshi, T., Komers, R., Herson, P. S., & Anderson, S. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00354.2011 · Cited by 148 · see citing works

Mechanisms of Estradiol-Induced Insulin Secretion by the G Protein-Coupled Estrogen Receptor GPR30/GPER in Pancreatic β-Cells

Sharma, G., & Prossnitz, E. R. (2011) · Endocrinology · doi:10.1210/en.2011-0091 · Cited by 143 · see citing works

Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT

Francesco, E. M. D., Maggiolini, M., & Musti, A. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072011 · Cited by 143 · see citing works

GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer

Mo, Z., Liu, M., Yang, F., Luo, H., Li, Z., Tu, G., & Yang, G. (2013) · Breast Cancer Research · doi:10.1186/bcr3581 · Cited by 134 · see citing works

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

Natale, C. A., Duperret, E. K., Zhang, J., Sadeghi, R. S., Dahal, A., O'Brien, K. T., Cookson, R., Winkler, J. D., & Ridky, T. W. (2016) · eLife · doi:10.7554/elife.15104 · Cited by 134 · see citing works

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: EFFECT ON OESTROGEN BINDING

Jordan, V. C., & DOWSE, L. J. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0680297 · Cited by 133 · see citing works

GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens

Francesco, E. M. D., PELLEGRINO, M. A., Santolla, M. F., Lappano, R., Ricchio, E., Abonante, S., & Maggiolini, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3590 · Cited by 130 · see citing works

Activation of G protein‐coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy

Feng, Y., Madungwe, N. B., Junho, C. V. C., & Bopassa, J. C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14033 · Cited by 129 · see citing works

Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma

Chakraborty, B., Byemerwa, J. K., Shepherd, J., Haines, C., Baldi, R., Gong, W., Liu, W., Mukherjee, D., Artham, S., Lim, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151347 · Cited by 128 · see citing works

Estradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke

Zhang, B., Subramanian, S., Dziennis, S., Jia, J., Uchida, M., Akiyoshi, K., Migliati, E., Lewis, A. D., Vandenbark, A. A., Offner, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902339 · Cited by 127 · see citing works

Role of GPER in estrogen-dependent nitric oxide formation and vasodilation

Fredette, N. C., Meyer, M. R., & Prossnitz, E. R. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.05.006 · Cited by 126 · see citing works

Contributions of sex to cerebrovascular function and pathology

Robison, L. S., Gannon, O. J., Salinero, A. E., & Zuloaga, K. L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.030 · Cited by 124 · see citing works

Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats

Wang, H., Jessup, J. A., Lin, M. S., Chagas, C., Lindsey, S. H., & Groban, L. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs090 · Cited by 121 · see citing works

The History of DES, Lessons to be Learned

Veurink, M., Koster, M. E., & den Berg, L. T. W. D. J. (2005) · Pharmacy World & Science · doi:10.1007/s11096-005-3663-z · Cited by 121 · see citing works

The Women's Health Initiative trial and related studies: 10 years later: A clinician's view

Gurney, E. P., Nachtigall, M. J., Nachtigall, L. E., & Naftolin, F. N. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.009 · Cited by 119 · see citing works

Sex and the kidneys: current understanding and research opportunities

Merz, C. N. B., Dember, L. M., Ingelfinger, J. R., Vinson, A. J., Neugarten, J., Sandberg, K. L., Sullivan, J. C., Maric‐Bilkan, C., Rankin, T. L., Kimmel, P. L., et al. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0208-6 · Cited by 119 · see citing works

Expression and Signaling of G Protein-Coupled Estrogen Receptor 1 (GPER) in Rat Sertoli Cells1

Lucas, T. F. G., Royer, C., Siu, E. R., Lazari, M. F. M., & Porto, C. S. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.084160 · Cited by 119 · see citing works

The G-protein coupled estrogen receptor, GPER: The inside and inside-out story

Gaudet, H. M., Cheng, S., Christensen, E. M., & Filardo, E. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.016 · Cited by 117 · see citing works

The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes

Recchia, A. G., Francesco, E. M. D., Vivacqua, A., Sisci, D., Panno, M. L., Andò, S., & Maggiolini, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172247 · Cited by 116 · see citing works

Dilation of Epicardial Coronary Arteries by the G Protein-Coupled Estrogen Receptor Agonists G-1 and ICI 182,780

Meyer, M. R., Baretella, O., Prossnitz, E. R., & Barton, M. (2010) · Pharmacology · doi:10.1159/000315497 · Cited by 116 · see citing works

Estrogen Receptor GPR30 Reduces Oxidative Stress and Proteinuria in the Salt-Sensitive Female mRen2.Lewis Rat

Lindsey, S. H., Yamaleyeva, L. M., Brosnihan, K. B., Gallagher, P. E., & Chappell, M. C. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175174 · Cited by 112 · see citing works

GPER Mediates Estrogen-Induced Signaling and Proliferation in Human Breast Epithelial Cells and Normal and Malignant Breast

Scaling, A. L., Prossnitz, E. R., & Hathaway, H. J. (2014) · Hormones and Cancer · doi:10.1007/s12672-014-0174-1 · Cited by 110 · see citing works

GPR30 mediates estrogen rapid signaling and neuroprotection

Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W., & Wang, R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.024 · Cited by 110 · see citing works

RHYTHMIC VASCULAR UTERINE CHANGES

Markee, J. E. (1932) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1932.100.1.32 · Cited by 110 · see citing works

Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Chaturantabut, S., Shwartz, A., Evason, K. J., Cox, A. G., LaBella, K. A., Schepers, A. G., Yang, S. P., Acuña, M., Houvras, Y. J., Mâncio-Silva, L., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.010 · Cited by 108 · see citing works

Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling

Lindsey, S. H., Liu, L., & Chappell, M. C. (2013) · Steroids · doi:10.1016/j.steroids.2013.10.017 · Cited by 107 · see citing works

A novel putative G‐protein‐coupled receptor expressed in lung, heart and lymphoid tissue

Kvingedal, A. M., & Smeland, E. B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00278-0 · Cited by 106 · see citing works

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

Sharma, G., Hu, C., Staquicini, D. I., Brigman, J. L., Liu, M., Mauvais‐Jarvis, F., Pasqualini, R., Arap, W., Arterburn, J. B., Hathaway, H. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aau5956 · Cited by 105 · see citing works

Attenuation of Salt-Induced Cardiac Remodeling and Diastolic Dysfunction by the GPER Agonist G-1 in Female mRen2.Lewis Rats

Jessup, J. A., Lindsey, S. H., Wang, H., Chappell, M. C., & Groban, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015433 · Cited by 104 · see citing works

Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis

Davis, K. E., Carstens, E. J., Irani, B. G., Gent, L. M., Hahner, L., & Clegg, D. J. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.02.004 · Cited by 103 · see citing works

Cloning of a Novel Member of the G Protein-Coupled Receptor Family Related to Peptide Receptors

Feng, Y., & Gregor, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6161 · Cited by 102 · see citing works

Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone

Cheng, S., Dong, J., Pang, Y., LaRocca, J. L., Hixon, M. L., Thomas, P., & Filardo, E. J. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.11.005 · Cited by 102 · see citing works

Hormonal Action of Plant Derived and Anthropogenic Non-Steroidal Estrogenic Compounds: Phytoestrogens and Xenoestrogens

Lóránd, T., Vigh, É., & Garai, J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710792927813 · Cited by 101 · see citing works

Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1

Brunsing, R. L., & Prossnitz, E. R. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03471.x · Cited by 100 · see citing works

Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth

Catalano, S., Giordano, C., Panza, S., Chemi, F., Bonofiglio, D., Lanzino, M., Rizza, P., Romeo, F., Fuqua, S. A. W., Maggiolini, M., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3017-4 · Cited by 97 · see citing works

Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1)

Ghaffari, S., Nabi, F. N., Sugiyama, M. G., & Lee, W. L. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310792 · Cited by 97 · see citing works

Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle

Yu, X., Ma, H., Barman, S. A., Liu, A. T., Sellers, M., Stallone, J. N., Prossnitz, E. R., White, R. E., & Han, G. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00037.2011 · Cited by 96 · see citing works

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak‐Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aad8170 · Cited by 95 · see citing works

Oleuropein and hydroxytyrosol activate GPER / GPR 30‐dependent pathways leading to apoptosis of ER ‐negative SKBR 3 breast cancer cells

Chimento, A., Casaburi, I., Rosano, C., Avena, P., Luca, A. D., Campana, C., Martire, E., Santolla, M. F., Maggiolini, M., Pezzi, V., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300323 · Cited by 94 · see citing works

MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells

Lappano, R., Santolla, M. F., Pupo, M., Sinicropi, M. S., Caruso, A., Rosano, C., & Maggiolini, M. (2012) · Breast Cancer Research · doi:10.1186/bcr3096 · Cited by 94 · see citing works

GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages

Rettew, J. A., McCall, S. H., & Marriott, I. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.07.017 · Cited by 93 · see citing works

G Protein–Coupled Estrogen Receptor Regulates Mammary Tumorigenesis and Metastasis

Marjon, N. A., Hu, C., Hathaway, H. J., & Prossnitz, E. R. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0128-t · Cited by 92 · see citing works

GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts

Luo, H., Yang, G., Yu, T., Luo, S., Wu, C., Sun, Y., Liu, M., & Tu, G. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0237 · Cited by 89 · see citing works

Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice

Balhuizen, A., Kumar, R., Amisten, S., Lundquist, I., & Salehi, A. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.030 · Cited by 84 · see citing works

Rescue of Pressure Overload‐Induced Heart Failure by Estrogen Therapy

Iorga, A., Li, J., Sharma, S., Umar, S., Bopassa, J. C., Nadadur, R. D., Centala, A., Ren, S. V., Saito, T., Toro, L., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002482 · Cited by 83 · see citing works

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

Marco, P. D., Lappano, R., Francesco, E. M. D., Cirillo, F., Pupo, M., Avino, S., Vivacqua, A., Abonante, S., Picard, D., & Maggiolini, M. (2016) · Scientific Reports · doi:10.1038/srep24354 · Cited by 82 · see citing works

Insulinotropic and Antidiabetic Effects of 17β-Estradiol and the GPR30 Agonist G-1 on Human Pancreatic Islets

Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. A. (2011) · Endocrinology · doi:10.1210/en.2010-1361 · Cited by 80 · see citing works

Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells

Lappano, R., Rosano, C., Santolla, M. F., Pupo, M., Francesco, E. M. D., Marco, P. D., Ponassi, M., Spallarossa, A., Ranise, A., & Maggiolini, M. (2012) · Current Cancer Drug Targets · doi:10.2174/156800912800673284 · Cited by 80 · see citing works

Regulation of Vascular Smooth Muscle Tone by Adipose-Derived Contracting Factor

Meyer, M. R., Fredette, N. C., Barton, M., & Prossnitz, E. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079245 · Cited by 79 · see citing works

Obligatory role for GPER in cardiovascular aging and disease

Meyer, M. R., Fredette, N. C., Daniel, C., Sharma, G., Amann, K., Arterburn, J. B., Barton, M., & Prossnitz, E. R. (2016) · Science Signaling · doi:10.1126/scisignal.aag0240 · Cited by 78 · see citing works

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment

Cortés, E., Sarper, M., Robinson, B. K., Lachowski, D., Chronopoulos, A., Thorpe, S. D., Lee, D. A., & Hernández, A. E. D. R. (2018) · EMBO Reports · doi:10.15252/embr.201846556 · Cited by 78 · see citing works

GPER/Hippo-YAP signal is involved in Bisphenol S induced migration of triple negative breast cancer (TNBC) cells

Deng, Q., Jiang, G., Wu, Y., Li, J., Liang, W., Chen, L., Su, Q., Li, W., Du, J., Wong, C. K. C., et al. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.05.013 · Cited by 77 · see citing works

G protein‐coupled oestrogen receptor promotes cell growth of non‐small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling

Shen, Y., Li, C., Zhou, L. M., & Huang, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15997 · Cited by 77 · see citing works

Estrogens and Coronary Artery Disease

Meyer, M. R., & Barton, M. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.05.003 · Cited by 76 · see citing works

G protein‐coupled estrogen receptor and estrogen receptor ligands regulate colonic motility and visceral pain

Zielińska, M., Fichna, J., Bashashati, M., Habibi, S., Sibaev, A., Timmermans, J., & Storr, M. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13025 · Cited by 76 · see citing works

2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats

Tofovic, S. P., Zhang, X., Jackson, E. K., Zhu, H., & Petruševska, G. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.06.002 · Cited by 76 · see citing works

G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

Jacenik, D., Beswick, E. J., Krajewska, W. M., & Prossnitz, E. R. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i30.4092 · Cited by 76 · see citing works

G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion

Kabir, M. E., Singh, H., Lü, R., Olde, B., Leeb-Lundberg, L. M. F., & Bopassa, J. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135988 · Cited by 75 · see citing works

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

Natale, C. A., Li, J., Pitarresi, J. R., Norgard, R. J., Dentchev, T., Capell, B. C., Seykora, J. T., Stanger, B. Z., & Ridky, T. W. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.016 · Cited by 75 · see citing works

Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung

Bonini, J. A., Anderson, S. M., & Steiner, D. F. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6591 · Cited by 74 · see citing works

GPER regulates endothelin-dependent vascular tone and intracellular calcium

Meyer, M. R., Field, A. S., Kanagy, N. L., Barton, M., & Prossnitz, E. R. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.01.007 · Cited by 72 · see citing works

Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF‐κB signals

Chen, Z.-J., Wei, W., Jiang, G.-M., Liu, H., Wei, W.-D., Yang, X., Wu, Y.-M., Liu, H., Wong, C. K. C., Du, J., et al. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.01.002 · Cited by 72 · see citing works

Activation of G protein‐coupled receptor 30 protects neurons by regulating autophagy in astrocytes

Wang, X., Yue, J., Hu, L., Tian, Z., Zhang, K., Yang, L., Zhang, H., Guo, Y., Feng, B., Liu, H., et al. (2019) · Glia · doi:10.1002/glia.23697 · Cited by 71 · see citing works

Use of PROTACS as molecular probes of angiogenesis

Bargagna‐Mohan, P., Baek, S., Lee, H., Kim, K., & Mohan, R. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.04.008 · Cited by 70 · see citing works

GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells

Rigiracciolo, D. C., Scarpelli, A., Lappano, R., Pisano, A., Santolla, M. F., Avino, S., Marco, P. D., Bussolati, B., Maggiolini, M., & Francesco, E. M. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6475 · Cited by 70 · see citing works

G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis

Wei, T., Chen, W., Wen, L., Zhang, J., Zhang, Q., Yang, J., Liu, H., Chen, B. W., Zhou, Y., Feng, X., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.012 · Cited by 70 · see citing works

The G Protein-coupled Estrogen Receptor (GPER) Agonist G-1 Expands the Regulatory T-cell Population Under TH17-polarizing Conditions

Brunsing, R. L., Owens, K., & Prossnitz, E. R. (2013) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31828d8e3b · Cited by 69 · see citing works

G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia

Du, Z., Feng, X., Li, N., Qu, J., Feng, L., Chen, L., & Chen, W. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.03.039 · Cited by 69 · see citing works

The effects of (−)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER)

Moreno‐Ulloa, A., Méndez-Luna, D., Beltrán‐Partida, E., Castillo, C., Guevara, G., Ramírez‐Sánchez, I., Correa‐Basurto, J., Ceballos, G. M., & Villarreal, F. J. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.08.014 · Cited by 67 · see citing works

G Protein–Coupled Estrogen Receptor Agonist Improves Cerebral Microvascular Function After Hypoxia/Reoxygenation Injury in Male and Female Rats

Murata, T., Dietrich, H. H., Xiang, C., & Dacey, R. G. (2013) · Stroke · doi:10.1161/strokeaha.112.678177 · Cited by 67 · see citing works

GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia

Hata, M., Kinoshita, H., Hayakawa, Y., Konishi, M., Tsuboi, M., Oya, Y., Kurokawa, K., Hayata, Y., Nakagawa, H., Tateishi, K., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.046 · Cited by 67 · see citing works

G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense

Bai, N., Zhang, Q., Zhang, W., Liu, B., Yang, F., Brann, D. W., & Wang, R. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1715-x · Cited by 65 · see citing works

GPER/ERK&AKT/NF-κB pathway is involved in cadmium-induced proliferation, invasion and migration of GPER-positive thyroid cancer cells

Zhu, P., Liao, L.-Y., Zhao, T., Mo, X.-M., Chen, G. Y., & Liu, Z. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.007 · Cited by 64 · see citing works

(-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor

Moreno‐Ulloa, A., Miranda‐Cervantes, A., Licea-Navarro, A. F., Mansour, C. M., Beltrán‐Partida, E., Donis‐Maturano, L., la Herrán, H. C. D.-D., Villarreal, F. J., & Álvarez‐Delgado, C. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.01.014 · Cited by 63 · see citing works

Pregnancy Augments G Protein Estrogen Receptor (GPER) Induced Vasodilation in Rat Uterine Arteries via the Nitric Oxide - cGMP Signaling Pathway

Tropea, T., Francesco, E. M. D., Rigiracciolo, D. C., Maggiolini, M., Wareing, M., Osol, G., & Mandalà, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141997 · Cited by 62 · see citing works

GPER1 is required to protect fetal health from maternal inflammation

Harding, A. T., Goff, M., Froggatt, H. M., Lim, J. K., & Heaton, N. S. (2021) · Science · doi:10.1126/science.aba9001 · Cited by 62 · see citing works

GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression

Santolla, M. F., Vivacqua, A., Lappano, R., Rigiracciolo, D. C., Cirillo, F., Galli, G. R., Talia, M., Brunetti, G., Miglietta, A., Belfiore, A., et al. (2019) · Cells · doi:10.3390/cells8030223 · Cited by 61 · see citing works

G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer

Liu, C., Liao, Y., Fan, S., Fu, X., Xiong, J., Zhou, S., Zou, M., & Wang, J. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x15035795904677 · Cited by 60 · see citing works

Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice

de Bari, O., Wang, T. Y., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m059121 · Cited by 60 · see citing works

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter

Cheng, L., Poulsen, S. B., Wu, Q., Esteva‐Font, C., Olesen, E. T. B., Peng, L., Olde, B., Leeb-Lundberg, L. M. F., Pisitkun, T., Rieg, T., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018101025 · Cited by 59 · see citing works

Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells

Teng, Y., Radde, B. N., Litchfield, L. M., Ivanova, M. M., Prough, R. A., Clark, B. J., Doll, M. A., Hein, D. W., & Klinge, C. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.641167 · Cited by 58 · see citing works

Activation of G protein-coupled estrogen receptor 1 (GPER-1) ameliorates blood-brain barrier permeability after global cerebral ischemia in ovariectomized rats

Lu, D., Qu, Y., Shi, F., Feng, D., Tao, K. X., Gao, G., He, S., & Zhao, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.044 · Cited by 58 · see citing works

Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1

Waghulde, H., Cheng, X., Galla, S., Mell, B., Cai, J., Pruett‐Miller, S. M., Vázquez, G., Patterson, A. D., Kumar, M. V., & Joe, B. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11175 · Cited by 58 · see citing works

Issue Information

(2020) · The FASEB Journal · doi:10.1096/fsb2.21134 · Cited by 57 · see citing works

G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis

Zucchetti, A. E., Barosso, I. R., Boaglio, A. C., Basiglio, C. L., Miszczuk, G. S., Larocca, M. C., Ruiz, L. M., Davio, C. A., Roma, M. G., Crocenzi, F. A., et al. (2013) · Hepatology · doi:10.1002/hep.26752 · Cited by 56 · see citing works

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1

Bourque, M., Morissette, M., & Paolo, T. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.006 · Cited by 56 · see citing works

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

Wang, Z.-F., Pan, Z.-Y., Xu, C.-S., & Li, Z.-Q. (2017) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2016.11.138 · Cited by 56 · see citing works

GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions

Bustos, V., Nolan, Á. M., Nijhuis, A. M., Harvey, H. M., Parker, A., Poulsom, R., McBryan, J., Thomas, W., Silver, A. R., & Harvey, B. J. (2017) · Oncotarget · doi:10.18632/oncotarget.20653 · Cited by 56 · see citing works

Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils

Tamaki, M., Konno, Y., Kobayashi, Y., Takeda, M., Itoga, M., Moritoki, Y., Oyamada, H., Kayaba, H., Chihara, J., & Ueki, S. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.012 · Cited by 55 · see citing works

Protective Role of GPER Agonist G‐1 on Cardiotoxicity Induced by Doxorubicin

Francesco, E. M. D., Rocca, C., Scavello, F., Amelio, D., Pasqua, T., Rigiracciolo, D. C., Scarpelli, A., Avino, S., Cirillo, F., Amodio, N., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25585 · Cited by 55 · see citing works

G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma

Sun, M., Xie, H., Tang, Y., Lin, S., Li, J., Sun, S., Hu, X., Huang, Y., Shi, W., & Jian, D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.06.012 · Cited by 54 · see citing works

G protein-coupled estrogen receptor mediates anti-inflammatory action in Crohn’s disease

Jacenik, D., Zielińska, M., Mokrowiecka, A., Michlewska, S., Malecka-Panas, E. I., Kordek, R., Fichna, J., & Krajewska, W. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-43233-3 · Cited by 54 · see citing works

GPER Agonist G1 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson Disease

Guan, J., Yang, B., Fan, Y., & Zhang, J. (2017) · NeuroImmunoModulation · doi:10.1159/000478908 · Cited by 53 · see citing works

Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin

Castleman, M. J., Pokhrel, S., Triplett, K. D., Kusewitt, D. F., Elmore, B. O., Joyner, J. A., Femling, J., Sharma, G., Hathaway, H. J., Prossnitz, E. R., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700810 · Cited by 53 · see citing works

G Protein-Coupled Estrogen Receptor in Cancer and Stromal Cells: Functions and Novel Therapeutic Perspectives

Pepermans, R. A., Sharma, G., & Prossnitz, E. R. (2021) · Cells · doi:10.3390/cells10030672 · Cited by 53 · see citing works

Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat

Alencar, A. K. N., da Silva, J. S., Lin, M., Silva, A. M., Sun, X., Ferrario, C. M., Cheng, C., Sudo, R. T., Zapata‐Sudo, G., Wang, H., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw045 · Cited by 53 · see citing works

Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer's disease

Kubota, T., Matsumoto, H., & Kirino, Y. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.06.005 · Cited by 52 · see citing works

G Protein-Coupled Estrogen Receptor 1 Regulates Human Neutrophil Functions

Rodenas, M. C., Tamassia, N., Cabas, I., Calzetti, F., Meseguer, J., Cassatella, M. A., Ayala, A. G., & Mulero, V. (2017) · Biomedicine Hub · doi:10.1159/000454981 · Cited by 52 · see citing works

Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice

Cao, J., Lu, M., Yan, W., Li, L., & Ma, H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.025 · Cited by 51 · see citing works

Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein

Locher, R., Emmanuele, L., Suter, P. M., Vetter, W., & Barton, M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01535-7 · Cited by 50 · see citing works

17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1

Hofmeister, M. V., Damkier, H. H., Christensen, B. M., Olde, B., Leeb-Lundberg, L. M. F., Fenton, R. A., Prætorius, H. A., & Prætorius, J. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00343.2011 · Cited by 50 · see citing works

Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor

Greenlee, M. M., Mitzelfelt, J. D., Yu, L., Yue, Q., Duke, B. J., Harrell, C. S., Neigh, G. N., & Eaton, D. C. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00008.2013 · Cited by 50 · see citing works

Icariin modulates mitochondrial function and apoptosis in high glucose-induced glomerular podocytes through G protein-coupled estrogen receptors

Qiao, C., Ye, W., Li, S., Wang, H., & Ding, X. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.01.014 · Cited by 50 · see citing works

Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation

Li, F., Yu, X., Szynkarski, C. K., Meng, C., Zhou, B., Barhoumi, R., White, R. E., Heaps, C. L., Stallone, J. N., & Han, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064771 · Cited by 49 · see citing works

Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer

Lam, H., Ouyang, B., Chen, J., Ying, J., Wang, J., Wu, C., Li, J., Medvedovic, M., Vessella, R. L., & Ho, S. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0402 · Cited by 49 · see citing works

G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism

Hussain, Y., Ding, Q., Connelly, P. W., Brunt, J., Ban, M. R., McIntyre, A. D., Huff, M. W., Gros, R., Hegele, R. A., & Feldman, R. D. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304326 · Cited by 49 · see citing works

Resveratrol inhibits Kv2.2 currents through the estrogen receptor GPR30-mediated PKC pathway

Dong, W., Chen, J.-C., He, Y., Xu, J., & Mei, Y. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00146.2013 · Cited by 49 · see citing works

Alterations in the estrogen receptor profile of cardiovascular tissues during aging

Gurrala, R., Kilanowski‐Doroh, I., Hutson, D. D., Ogola, B. O., Zimmerman, M. A., Katakam, P. V. G., Satou, R., Mostany, R., & Lindsey, S. H. (2021) · GeroScience · doi:10.1007/s11357-021-00331-3 · Cited by 49 · see citing works

2-Methoxyestradiol binding of GPR30 down-regulates angiotensin AT1 receptor

Koganti, S., Snyder, R. O., Gumaste, U., Karamyan, V. T., & Thekkumkara, T. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.064 · Cited by 48 · see citing works

Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice

Meoli, L., Isensee, J., Zazzu, V., Nabzdyk, C. S., Soewarto, D., Witt, H., Foryst‐Ludwig, A., Kintscher, U., & Ruíz, P. (2014) · Gene · doi:10.1016/j.gene.2014.02.036 · Cited by 47 · see citing works

G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen

Ignatov, T., Claus, M., Naß, N., Haybaeck, J., Seifert, B., Kalinski, T., Ortmann, O., & Ignatov, A. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-5064-8 · Cited by 47 · see citing works

Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER

Gilligan, L. C., Rahman, H. P., Hewitt, A.-M., Sitch, A. J., Gondal, A., Arvaniti, A., TAYLOR, A. E. R., Read, M. L., Morton, D. G., & Foster, P. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3716 · Cited by 47 · see citing works

GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner

Ren, J., Guo, H., Wu, H., Tian, T., Dong, D., Zhang, Y., Sui, Y.-X., Zhang, Y., Zhao, D., Wang, S., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.3779 · Cited by 46 · see citing works

Vasodilatory effects of the selective GPER agonist G-1 is maximal in arteries of postmenopausal women

Arefin, S., Simoncini, T., Wieland, R. S., Hammarqvist, F., Spina, S., Goglia, L., & Kublickiene, K. R. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.04.002 · Cited by 46 · see citing works

A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women

Feldman, R. D., Gros, R., Ding, Q., Hussain, Y., Ban, M. R., McIntyre, A. D., & Hegele, R. A. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12471 · Cited by 46 · see citing works

17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor

Yasuda, H., Sonoda, A., Yamamoto, M., Kawashima, Y., Takishita, Y., Morita, A., Tsutsumi, T., Tsuchiya, M., & Sato, E. F. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.12.028 · Cited by 46 · see citing works

Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor

Gohar, E. Y., Daugherty, E. M., Aceves, J. O., Sedaka, R., Obi, I. E., Allan, J. M., Soliman, R. H., Jin, C., Miguel, C. D., Lindsey, S. H., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015110 · Cited by 46 · see citing works

G protein‐coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57 BL /6 female mice

Li, Y., Xu, J., Jiang, F., Jiang, Z., Liu, C., Li, L., Luo, Y., Lu, R., Mu, Y., Liu, Y., et al. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12743 · Cited by 45 · see citing works

Estrogen signaling deregulation related with local immune response modulation in irritable bowel syndrome

Jacenik, D., Cygankiewicz, A. I., Fichna, J., Mokrowiecka, A., Malecka-Panas, E. I., & Krajewska, W. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.036 · Cited by 45 · see citing works

Activation of GPR30 with G1 attenuates neuronal apoptosis via src/EGFR/stat3 signaling pathway after subarachnoid hemorrhage in male rats

Peng, J., Zuo, Y., Huang, L., Okada, T., Liu, S., Zuo, G., Zhang, G., Tang, J., Xia, Y., & Zhang, J. H. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113008 · Cited by 45 · see citing works

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER

Zekas, E., & Prossnitz, E. R. (2015) · BMC Cancer · doi:10.1186/s12885-015-1699-6 · Cited by 44 · see citing works

A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells

Pupo, M., Bodmer, A., Berto, M., Maggiolini, M., Dietrich, P., & Picard, D. (2017) · Oncotarget · doi:10.18632/oncotarget.18156 · Cited by 44 · see citing works

Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

Lo, E. K. K., Lee, J. C., Turner, P. C., & El-Nezami, H. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-86788-w · Cited by 44 · see citing works

Purification of estradiol receptor from rat uterus and blockade of its estrogen-binding function by specific antibody

Soloff, M. S., & Szego, C. M. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90540-3 · Cited by 43 · see citing works

Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA

Yu, X., Zhang, Q., Zhao, Y., Schwarz, B. J., Stallone, J. N., Heaps, C. L., & Han, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173085 · Cited by 43 · see citing works

Cardioprotective and anti-inflammatory effects of G-protein coupled receptor 30 (GPR30) on postmenopausal type 2 diabetic rats

Azizian, H., Khaksari, M., Asadikaram, G., Esmailidehaj, M., & Farhadi, Z. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.028 · Cited by 43 · see citing works

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments

Hsu, S.-H., Chen, L.-R., & Chen, K.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212139 · Cited by 90 · see citing works

Identification, structure, and agonist design of an androgen membrane receptor

Yang, Z., Ping, Y.-Q., Wang, M., Zhang, C., Zhou, S., Xi, Y.-T., Zhu, K., Ding, W., Zhang, Q., Song, Z.-C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.01.006 · Cited by 74 · see citing works

Treating ER-positive breast cancer: a review of the current FDA-approved SERMs and SERDs and their mechanisms of action

Kim, N., & Lukong, K. E. (2025) · Oncology Reviews · doi:10.3389/or.2025.1564642 · Cited by 73 · see citing works

Estrogen-immuno-neuromodulation disorders in menopausal depression

Zhang, Y., Tan, X., & Tang, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03152-1 · Cited by 67 · see citing works

From physiology to pathology: Emerging roles of GPER in cardiovascular disease

Wang, Z., Liu, J., Chen, Y., Tang, Y., Chen, T., Zhou, C. S., Wang, S., Chang, R., Chen, Z., Yang, W., et al. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108801 · Cited by 57 · see citing works

The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy

Dong, J., Dennis, K. M. J. H., Venkatakrishnan, R., Hodson, L., & Tomlinson, J. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf018 · Cited by 61 · see citing works

Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis

Saavedra-Torres, J. S., Fernández, M. V. P., Ocampo-Posada, M., Nati-Castillo, H. A., Hincapie, L. A. J., Cadrazo-Gil, E. J., Arias-Intriago, M., Rojas-Cadena, M., Tello-De-la-Torre, A., Osejos, W., et al. (2025) · Cells · doi:10.3390/cells14120930 · Cited by 50 · see citing works

CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease

Zuo, F., Wang, Y., Xu, X., Ding, R., Tang, W., Sun, Y., Wang, X., Zhang, Y., Wu, J., Xie, Y., et al. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155724 · Cited by 38 · see citing works

Roles of estrogen and its receptors in polycystic ovary syndrome

Xu, Y., Zhang, Z., Wang, R., Xue, S., Ying, Q., & Jin, L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1395331 · Cited by 38 · see citing works

Sex and sex steroids as determinants of cardiovascular risk

Cignarella, A., Bolego, C., & Barton, M. (2024) · Steroids · doi:10.1016/j.steroids.2024.109423 · Cited by 37 · see citing works

The role of estrogen receptors in intracellular estrogen signaling pathways, an overview

Gui, Z., Shi, W., Zhou, F., Yan, Y., Li, Y., & Xu, Y. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106632 · Cited by 34 · see citing works

Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges

Fang, C., Zeng, Z., Ni, B., Wen, X., Fang, Z., Zou, J., & Zhang, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1681875 · Cited by 29 · see citing works

Structural and functional evidence that GPR30 is not a direct estrogen receptor

Liu, H., Guo, S., Dai, A., Xu, P., Li, X., Huang, S., He, X., Wu, K., Zhang, X., Yang, D., et al. (2024) · Cell Research · doi:10.1038/s41422-024-00963-y · Cited by 27 · see citing works

Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients

Talia, M., Cesario, E., Cirillo, F., Scordamaglia, D., Dio, M. D., Zicarelli, A., Mondino, A. A., Occhiuzzi, M. A., Francesco, E. M. D., Belfiore, A., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05413-2 · Cited by 28 · see citing works

Health of adipose tissue: oestrogen matters

Vieira‐Potter, V. J., Mishra, G., & Townsend, K. L. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01180-2 · Cited by 27 · see citing works

Nuclear Estrogen Receptors in Prostate Cancer: From Genes to Function

Belluti, S., Imbriano, C., & Casarini, L. (2023) · Cancers · doi:10.3390/cancers15184653 · Cited by 29 · see citing works

Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease

Gu, Y., Hu, Z., Zheng, D., Yang, Y., Dong, X., & Chen, W. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155435 · Cited by 24 · see citing works

Exploring the physiological role of the G protein-coupled estrogen receptor (GPER) and its associations with human diseases

Żabińska, M., Wiśniewska, K., Węgrzyn, G., & Pierzynowska, K. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107070 · Cited by 24 · see citing works

Salt sensitivity of blood pressure: mechanisms and sex-specific differences

Masenga, S. K., Wandira, N., Cattivelli-Murdoch, G., Saleem, M., Beasley, H. K., Hinton, A. O., Jr., Ertuğlu, L. A., Mwesigwa, N., Kleyman, T. R., & Kirabo, A. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01135-0 · Cited by 27 · see citing works

Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload

Fukuma, N., Tokiwa, H., Numata, G., Ueda, K., Liu, P., Tajima, M., Otsu, Y., Kariya, T., Hiroi, Y., Liao, J. K., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae202 · Cited by 21 · see citing works

Estrogen: the forgotten player in metaflammation

Zhu, B. T., Liao, Q.-Q., Tian, H., Yu, D., Xie, T., Sun, X., Zhou, X.-M., Han, Y., Zhao, Y., El‐Kassas, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1478819 · Cited by 22 · see citing works

Sex differences in bladder cancer: understanding biological and clinical implications

Chaudhary, P., Singha, B., Abdel-Hafiz, H. A., Velegraki, M., Sundi, D., Satturwar, S. P., Parwani, A. V., Grivennikov, S. I., You, S., Goodridge, H. S., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00715-6 · Cited by 25 · see citing works

Sex Differences in Colon Cancer: Genomic and Nongenomic Signalling of Oestrogen

Harvey, B. J., & Harvey, H. M. (2023) · Genes · doi:10.3390/genes14122225 · Cited by 20 · see citing works

GPR30-driven fatty acid oxidation targeted by ginsenoside Rd maintains mitochondrial redox homeostasis to restore vascular barrier in diabetic retinopathy

Tang, K., Huang, C., Huang, Z., Wang, Z., & Tan, N. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02638-3 · Cited by 19 · see citing works

F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis

Nie, P., Lan, Y., You, T., Jia, T., & Xu, H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116399 · Cited by 19 · see citing works

Inflammatory burden index (IBI) and body roundness index (BRI) in gallstone risk prediction: insights from NHANES 2017–2020

Gu, Y., Zhou, Z., Zhao, X., Ye, X., Qin, K., Liu, J., Zhang, X., & Ji, Y. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02472-2 · Cited by 18 · see citing works

Molecular insights into the potential effects of selective estrogen receptor β agonists in Alzheimer's and Parkinson's diseases

Rymbai, E., Sugumar, D., Chakkittukandiyil, A., Kothandan, R., & Selvaraj, D. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4014 · Cited by 18 · see citing works

Selenium restored mitophagic flux to alleviate cadmium-induced hepatotoxicity by inhibiting excessive GPER1-mediated mitophagy activation

Zhang, H., Yan, J., Xie, D., Zhu, X., Nie, G., Zhang, H., & Li, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134855 · Cited by 17 · see citing works

Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling

Cignarella, A., Boscaro, C., Albiero, M., Bolego, C., & Barton, M. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001613 · Cited by 17 · see citing works

Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways

He, T.-T., Li, X., Ma, J., Yang, Y., Zhu, S., Zeng, J., Luo, L., Yin, Y., & Cao, L.-Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172782 · Cited by 17 · see citing works

Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB–neuT Mice

Focaccetti, C., Nardozi, D., Benvenuto, M., Lucarini, V., Angiolini, V., Carrano, R., Scimeca, M., Servadei, F., Mauriello, A., Mancini, P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116259 · Cited by 17 · see citing works

Sex-Related Differences in Pancreatic Ductal Adenocarcinoma Progression and Response to Therapy

Grahovac, J., Djurić, A., Tanić, M., & Krivokuća, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312669 · Cited by 17 · see citing works

Bisphenols and brominated bisphenols induced endothelial dysfunction via its disruption of endothelial nitric oxide synthase

Hu, C., Lu, L., Guo, C., Zhan, T., Zhang, X., & Zhang, H. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123600 · Cited by 16 · see citing works

Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα−positive breast cancer

Saha, T., & Lukong, K. E. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1513225 · Cited by 19 · see citing works

The Expression of Adipogenic Marker Is Significantly Increased in Estrogen-Treated Lipedema Adipocytes Differentiated from Adipose Stem Cells In Vitro

Al-Ghadban, S. I., Isern, S. U., Herbst, K. L., & Bunnell, B. A. (2024) · Biomedicines · doi:10.3390/biomedicines12051042 · Cited by 15 · see citing works

Impact of Gut and Reproductive Tract Microbiota on Estrogen Metabolism in Endometriosis

Li, Z., Yin, Z., Chen, W. X., & Wang, Z. (2025) · American Journal of Reproductive Immunology · doi:10.1111/aji.70109 · Cited by 15 · see citing works

G protein-coupled estrogen receptor biased signaling in health and disease

Bushi, A., Ma, Y., Adu‐Amankwaah, J., Wang, R., Cui, F., Xiao, R., Zhao, J., Yuan, J., & Tan, R. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108822 · Cited by 14 · see citing works

GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential

Liu, L., Zhou, Y., Liu, J., Zhang, X., He, C., Zeng, X., Dejenie, R., Zeb, U., Zeng, Q., Liu, L., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07005-0 · Cited by 13 · see citing works

Mechanistic insights into the anti-fibrotic effects of estrogen via the PI3K-Akt pathway in frozen shoulder

Wang, Z., Li, X., Liu, X., Yang, Y., Yan, Y., Cui, D., Meng, C., Ali, M. I., Zhang, J., Yao, Z., et al. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106701 · Cited by 13 · see citing works

Sex Chromosomes and Sex Hormones: Dissecting the Forces That Differentiate Female and Male Hearts

Brong, A., & Kontrogianni‐Konstantopoulos, A. (2025) · Circulation · doi:10.1161/circulationaha.124.069493 · Cited by 13 · see citing works

Activation of GPER1 by G1 prevents PTSD ‐like behaviors in mice: Illustrating the mechanisms from BDNF / TrkB to mitochondria and synaptic connection

Chen, L., Zhang, Y., Wang, Z., Zhang, Z., Wang, J., Zhu, G., & Yang, S. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14855 · Cited by 13 · see citing works

Dioscin improves fatty liver hemorrhagic syndrome by promoting ERα-AMPK mediated mitophagy in laying hens

Xing, Y., Huang, B., Cui, Z., Zhang, Q., & Ma, H. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156056 · Cited by 14 · see citing works

Mitogen-Activated Protein Kinase and Exploratory Nuclear Receptor Crosstalk in Cancer Immunotherapy

Burgermeister, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914546 · Cited by 13 · see citing works

The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer

Talia, M., Cirillo, F., Scordamaglia, D., Dio, M. D., Zicarelli, A., Rosis, S. D., Miglietta, A., Capalbo, C., Francesco, E. M. D., Belfiore, A., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03096-7 · Cited by 12 · see citing works

Sex hormones and immune regulation in ovarian cancer

Zhao, R., Lian, W., & Xu, Q. (2024) · Discover Oncology · doi:10.1007/s12672-024-01675-w · Cited by 12 · see citing works

Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER

Hussein, S. A., Ababneh, N. A., Tarawneh, N., Ismail, M. A., Awidi, A., & Abdalla, S. (2025) · Life · doi:10.3390/life15030417 · Cited by 12 · see citing works

Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes

Mei, Z., Liu, J., Bennett, D. A., Seyfried, N., Wingo, A. P., & Wingo, T. S. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70206 · Cited by 11 · see citing works

Proteomic Analyses of the G Protein-Coupled Estrogen Receptor GPER1 Reveal Constitutive Links to Endoplasmic Reticulum, Glycosylation, Trafficking, and Calcium Signaling

Elmi, M. A., Motamed, N., & Picard, D. (2023) · Cells · doi:10.3390/cells12212571 · Cited by 11 · see citing works

Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells

Cirillo, F., Spinelli, A., Talia, M., Scordamaglia, D., Santolla, M. F., Grande, F., Rizzuti, B., Maggiolini, M., Gérard, C., & Lappano, R. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05269-6 · Cited by 11 · see citing works

The immune–endocrine interplay in sex differential responses to viral infection and COVID-19

D’Onofrio, V., & Sékaly, R. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.10.004 · Cited by 11 · see citing works

TFAP2A drives non-small cell lung cancer (NSCLC) progression and resistance to targeted therapy by facilitating the ESR2-mediated MAPK pathway

Wang, D.-G., Gao, J., Wang, J., Li, K.-C., Wu, Z., Liao, Z., & Wu, Y.-B. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02251-5 · Cited by 11 · see citing works

LNS8801: An Enantiomerically Pure Agonist of the G Protein–Coupled Estrogen Receptor Suitable for Clinical Development

Natale, C. A., Mercado, S., Zhuang, R., Aguirre‐Portolés, C., Olayide, I., Arnatt, C. K., Seykora, J. T., Garyantes, T. K., Luke, W., & Ridky, T. W. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0632 · Cited by 11 · see citing works

Gut–Vaginal Microbiome Crosstalk in Ovarian Cancer: Implications for Early Diagnosis

Zhang, H., Lin, H., Zeng, Z., Jia, Y., Zhang, H., Pang, J. M., & Chen, J. J. (2025) · Pathogens · doi:10.3390/pathogens14070635 · Cited by 11 · see citing works

GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol

Arisawa, K., Matsuoka, A., Ozawa, N., Ishikawa, T., Ichi, I., & Fujiwara, Y. (2023) · Nutrients · doi:10.3390/nu16010038 · Cited by 10 · see citing works

17β-estradiol in colorectal cancer: friend or foe?

Wu, Z., Xiao, C., Wang, J., Zhou, M., You, F., & Li, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01745-0 · Cited by 11 · see citing works

The Loss of Estradiol by Androgen Deprivation in Prostate Cancer Patients Shows the Importance of Estrogens in Males

Bennink, H. J. T. C., Prowse, A. H., Egberts, J. F. M., Debruyne, F. M. J., Huhtaniemi, I. T., & TOMBAL, B. F. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae107 · Cited by 10 · see citing works

An update on regulation and function of G protein-coupled receptors in cancer: A promising strategy for cancer therapy

Li, L., An, Z., Lin, C., Xu, Q., & Tang, C. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189266 · Cited by 10 · see citing works

A deadly taste: linking bitter taste receptors and apoptosis

Miller, Z. A., Carey, R. M., & Lee, R. J. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02091-3 · Cited by 10 · see citing works

The G Protein-Coupled Estrogen Receptor GPER in the Development and Progression of Cancer

Torres-López, L., Olivas-Aguirre, M., & Dobrovinskaya, O. R. (2024) · Receptors · doi:10.3390/receptors3020012 · Cited by 9 · see citing works

Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice

Hjelt, A., Anttila, S., Wiklund, A., Rokka, A., Al-Ramahi, D., Toivola, D. M., Polari, L., & Määttä, J. A. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1234 · Cited by 8 · see citing works

Estrogen Promotes the Proliferation and Migration of Endometrial Cancer Through the GPER‐Mediated NOTCH Pathway

Qi, M., Jin, Y., Si, L., Fu, H., Shi, X., Liu, Y., Wang, Y., & Guo, R. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70129 · Cited by 9 · see citing works

17β-Estradiol promotes LL37-induced rosacea-like skin inflammation via G protein-coupled estrogen receptor 30

Tang, J., Chen, P., Huang, C., Wang, W., Wang, B., Shi, W., Tang, Y., Deng, Z., Zhang, Y., Li, J., et al. (2025) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2025.05.005 · Cited by 9 · see citing works

From Nuclear Receptors to GPCRs: a Deep Transfer Learning Approach for Enhanced Environmental Estrogen Recognition

Yao, T., Luo, J., Han, X., Yi, H., Zhang, H., Pan, W., Xue, Q., Liu, X., Fu, J., & Zhang, A. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c02014 · Cited by 8 · see citing works

Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief

Frick, K. M., Fleischer, A. W., Schwabe, M. R., Abdelazim, F. A., Sem, D. S., & Donaldson, W. A. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105773 · Cited by 8 · see citing works

Progress of estrogen receptor and spliceosome in endometrial carcinoma

Hong, Z., Mo, T., Zhou, P., Chen, J., & Li, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1586191 · Cited by 8 · see citing works

17-β-estradiol potentiates the neurotrophic and neuroprotective effects mediated by the dopamine D3/acetylcholine nicotinic receptor heteromer in dopaminergic neurons

Sbrini, G., Mutti, V., Bono, F., Tomasoni, Z., Fadel, D., Missale, C., & Fiorentini, C. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176678 · Cited by 8 · see citing works

GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma

Fan, L., Wang, X., Zhang, X.-M., Wei, Z.-Y., Wu, H., Yang, Q.-X., Fu, D., de Mello, R. A., Lin, J.-W., Hong, Y., et al. (2025) · Translational Lung Cancer Research · doi:10.21037/tlcr-2024-1200 · Cited by 7 · see citing works

Control of sodium appetite by hindbrain aldosterone-sensitive neurons

Kuralay, A., McDonough, M. C., & Resch, J. M. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112323 · Cited by 7 · see citing works

Interaction of GPER-1 with the endocrine signaling axis in breast cancer

Molina, L., Arancibia, Y., Olivera, M. A., Domke, S., & Torres, R. F. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1494411 · Cited by 7 · see citing works

Canonical or non‐canonical, all aspects of G protein‐coupled receptor kinase 2 in heart failure

Kaplan, A., El‐Samadi, L., Zahreddine, R., Amin, G., Booz, G. W., & Zouein, F. A. (2025) · Acta Physiologica · doi:10.1111/apha.70010 · Cited by 7 · see citing works

Accelerometer-measured circadian alignment predicts all-cause and cardiovascular mortality in middle-aged and older adults

Xie, J., Qian, T., Lin, P., Gao, H., Xu, C., & Xu, L. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf445 · Cited by 6 · see citing works

Genistein maintains intestinal homeostasis in colitis mice via activating GPR30-Nrf2 signaling pathway

Cao, J., Shi, D., Cui, Y., Zhu, H., Liang, H., Wei, Q., & Huang, J. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110036 · Cited by 6 · see citing works

MicroRNAs regulate the vicious cycle of vascular calcification-osteoporosis in postmenopausal women

Wang, Q., Peng, F., Yang, J., Chen, X., Peng, Z., Zhang, M., Tang, D., Liu, J., & Zhao, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09550-1 · Cited by 6 · see citing works

The G-Protein-Coupled Estrogen Receptor Agonist G-1 Mediates Antitumor Effects by Activating Apoptosis Pathways and Regulating Migration and Invasion in Cervical Cancer Cells

Gaxiola-Rubio, A., Jave‐Suárez, L. F., Hernández-Silva, C. D., Ramírez-de-Arellano, A., Villegas‐Pineda, J. C., Lizárraga-Ledesma, M. D. J., Ramos‐Solano, M., Díaz-Palomera, C. D., & Pereira-Suárez, A. L. (2024) · Cancers · doi:10.3390/cancers16193292 · Cited by 6 · see citing works

The spatial and temporal pattern of GPER/GPR30 reporter expression in the developing and mature forebrain of mice

Wu, M., He, W., Gong, H., Dong, L., Ding, N., Zhang, G., Wang, J., & Rong, W. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111276 · Cited by 6 · see citing works

Estrogen attenuates stiffness-driven fibrotic signaling via transcriptional regulation

Zhu, H., Wang, J., Liu, Y., Wang, X., Lu, T. J., Feng, X., & Lin, M. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.05.007 · Cited by 6 · see citing works

Interference of estrogen signaling by endocrine disruptors in male and female cells: Potential implications of BPS and PFOS in human development

Gaggi, G., Credico, A. D., Bibbò, S., Corneo, B., Ferlin, A., Baldassarre, A. D., & Ghinassi, B. (2025) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2025.151509 · Cited by 6 · see citing works

Estrogen receptor GPR30 in the anterior cingulate cortex mediates exacerbated neuropathic pain in ovariectomized mice

Wang, J., Wang, S., Fang, Z., Zhao, J., Zhang, G., Guo, Y., Wang, Q., Jiang, Z., Zhong, H., & Hou, W. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148798 · Cited by 5 · see citing works

Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models

Mueller, M. C., Blomberg, R., Tanneberger, A. E., Davis‐Hall, D., Neeves, K. B., & Magin, C. M. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00123 · Cited by 5 · see citing works

Epigenetic Modulation of GPER Expression in Gastric and Colonic Smooth Muscle of Male and Female Non-Obese Diabetic (NOD) Mice: Insights into H3K4me3 and H3K27ac Modifications

Hixon, J. C., Zarete, J. I. R., White, J. A., Hilaire, M., Muhammad, A. I., Yusuf, A. P., Adu-Addai, B., Yates, C. C., & Mahavadi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105260 · Cited by 5 · see citing works

GPR30 Agonist G1 Mitigates Sepsis-Induced Cardiac Dysfunction by Inhibiting ACE2/c–FOS-Mediated Necroptosis in Female Mice

Wang, X., Wang, X., Ma, J., Zhang, S., Fang, W., Xu, F., Du, J., Liang, H., Duan, W., Li, Z., et al. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00319 · Cited by 5 · see citing works

GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma

Yang, Y., Wang, Y., Zou, H., Li, Z., Chen, W., Huang, Z., Weng, Y., Yu, X.-J., Xu, J., & Zheng, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1481972 · Cited by 5 · see citing works

Mineralocorticoid and estrogen receptors as sex-dependent modulators of vascular health in aging and obesity

Turner, C. G., de Oliveira, K., Jaffe, I. Z., & DuPont, J. J. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103591 · Cited by 5 · see citing works

Activation of G protein-coupled estrogen receptor alleviates the abnormal changes of synaptic plasticity in the anterior insula of temporal lobe epilepsy rats through RhoA/Rock2 pathway

Zhang, L., Liu, S., He, L., Qiang, Y., Wu, H., Li, Z., Li, G., Li, L., Wen, Y., Yang, Y., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144196 · Cited by 5 · see citing works

Appraising the causal association between Crohn’s disease and breast cancer: a Mendelian randomization study

Yu, C.-D., Xu, J.-W., Xu, S., Huang, Y., Tang, L., Zeng, X.-Q., Yu, T.-H., Chen, W., & Sun, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1275913 · Cited by 3 · see citing works

The GPER is an important factor through which somatic cells regulate oocyte maternal mRNA translation and developmental competence

Zhang, H., Li, C., Lu, S., Wu, H., Li, J., Liu, Q., Yan, Y., Tang, Y., Xu, R., Zhao, X., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138827 · Cited by 5 · see citing works

Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance

Yang, X., & Gu, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102218 · Cited by 4 · see citing works

Fluorescence-based techniques for investigating estrogen receptor dynamics

Han, K., Choi, G., & Kim, T. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0091 · Cited by 4 · see citing works

Design, Synthesis, and Antitumor Potential of New Thiazolecontained 5-Fluoro-2-Oxindole Derivatives as Sunitinib Analogues

Semenyuta, I. V., Los, O. V., Sinenko, V. O., Zhirnov, V. V., Потиха, Л. М., Kobzar, O. L., & Броварец, В. С. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673346427241016100726 · Cited by 4 · see citing works

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells

Zhu, Y., Wei, J., Yang, X., & Zhu, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1496393 · Cited by 4 · see citing works

Steroid hormones in pain: Mechanistic underpinnings and therapeutic perspectives

Zhang, X., Yang, X., Xu, Y., Xu, Y., Ji, Y., Jiang, C., Hu, S.-W., & Yang, C. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106769 · Cited by 4 · see citing works

Estrogen, Epigenetics, and Cardiometabolic Health: Mechanisms and Therapeutic Strategies in Postmenopausal Women

Edwards, A., Singh, P., Shah, V., Chander, V., & Mishra, S. (2026) · Cells · doi:10.3390/cells15060529 · Cited by 4 · see citing works

G‐protein‐coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1‐mediated redox modulation

Wu, T., Ding, K., Wang, C., Lin, G., Xie, C., Chen, X., Li, Q., Yu, F.-H., Mao, Y., Hong, W., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301172rrrr · Cited by 4 · see citing works

Global burden of subarachnoid hemorrhage among adolescents and young adults aged 15–39 years: A trend analysis study from 1990 to 2021

Liu, X., Cheng, R., Song, Y., Yang, X., Niu, X., Wang, C., Jia, G., & Ji, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0316111 · Cited by 4 · see citing works

G protein‐coupled estrogen receptor agonist G‐1 decreases ADAM10 levels and NLRP3‐inflammasome component activation in response to Staphylococcus aureus alpha‐hemolysin

Zheng, H., Triplett, K. D., Prossnitz, E. R., Hall, P. R., & Daly, S. M. (2024) · MicrobiologyOpen · doi:10.1002/mbo3.1423 · Cited by 3 · see citing works

Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafishPreprint

Yu, X., Yaman, M., Zhao, Q. Y., Emly, S. M., Lee, J. K., Su, H., Ferguson, A. C., Nagaswami, C., Chaturantabut, S., Goessling, W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.13.623199 · Cited by 4 · see citing works

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

Meng, X., Li, S., You, Y., Dai, H., Yu, M., Wang, F., Zhou, Z., Shan, Y., & Sheng, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1515038 · Cited by 4 · see citing works

Estrogen-mediated corneal collagen degradation in keratoconus

Chatterjee, A., Kanu, L. N., Boychev, N., Ross, A. E., Yeung, V., Venkateswaran, N., Saeed, H. N., & Ciolino, J. B. (2025) · iScience · doi:10.1016/j.isci.2025.113004 · Cited by 4 · see citing works

The role of GPER-mediated AMPKα signal in the prevention effect of (-)-epicatechin on metabolic dysfunction-associated steatohepatitis

Wang, Y., He, F., Zhao, S., Gong, P., & Ma, H. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110106 · Cited by 3 · see citing works

G Protein-Coupled Estrogen Receptor Regulates Mesenchymal Stem Cell Mechanotransduction and Differentiation

Wang, H., Menachem-Zidon, O. B., Pandey, A. K., Xiao, Y., Deng, N., Shi, X., Ruiz, A., Ye, Y., & Cai, H. (2025) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-025-00867-w · Cited by 3 · see citing works

The G-protein-coupled estrogen receptor GPER in health and disease

Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925 · see citing works

Estrogen biology: New insights into GPER function and clinical opportunities

Prossnitz, E. R., & Barton, M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.02.002 · Cited by 404 · see citing works

G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

Arterburn, J. B., & Prossnitz, E. R. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-121944 · Cited by 114 · see citing works

Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER

Barton, M. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.016 · Cited by 55 · see citing works

GPER–novel membrane oestrogen receptor

Zimmerman, M. A., Budish, R. A., Kashyap, S. N., & Lindsey, S. H. (2016) · Clinical Science · doi:10.1042/cs20160114 · Cited by 114 · see citing works