Cited by 344Hypothalamic control of reproductive hormonesReproductive Health and ContraceptionEstrogen and related hormone effects

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Induction of Ovulation with MRL/41: Preliminary Report

Greenblatt, Robert B.·1961·JAMA

DOI 10.1001/jama.1961.03040410001001

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Abstract

MRL/41, an analogue of the nonsteroid estrogen, chlorotrianisene, was evaluated in the human female because it was shown to possess pituitary gonadotropin-inhibiting and antifecundity properties in rats. Although structurally related to a hormone-like chemical agent, this compound does not exhibit estrogenic, progestogenic, or androgenic activity in the human. Studies with this drug were initiated primarily because of its potential as an antifertility agent. Contrary to expectations, some unsuspected and interesting biological activities were observed, one of which was the induction of ovulatorytype menses in amenorrheic anovulatory females.

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Authors: Greenblatt, R. B.
Corresponding author: Greenblatt, Robert B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1961-10-14
Volume: 178
Issue: 2
Pages: 101
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1961.03040410001001
OpenAlex: W2068435339
Cited by: 343
References: 4
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 6
FWCI: 21.92
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: ovulation induction, amenorrhea, anovulation, antifertility agents, gonadotropin suppression, menstrual induction
MeSH terms: Female, Humans, Ovulation, Stilbenes

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Induction of Ovulation with MRL/41: Preliminary Report

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