Testosterone Propionate Therapy in Breast Cancer

I S GOLDENBERG

doi:10.1001/jama.1964.03060380037009

Cited by 114Breast Cancer Treatment StudiesEstrogen and related hormone effectsMenopause: Health Impacts and Treatments

Testosterone Propionate Therapy in Breast Cancer

I S GOLDENBERG·1964·JAMA

DOI 10.1001/jama.1964.03060380037009

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Abstract

A CONTINUING collaborative study of hormonal therapy of recurrent, primary inoperable and metastatic carcinoma of the female breast, sponsored by the Cancer Chemotherapy National Service Center of the National Cancer Institute, has been conducted since 1957 by a group of investigators at 23 institutions. New hormonal preparations have been administered to patient groups under protocol standards1in double-blind fashion in conjunction with known hormonal reference standards. This procedure allows for objective evaluation of the new compounds as well as established anticancer agents such as testosterone propionate. The present report details results of testosterone propionate therapy in 521 women beginning therapy between Jan 16, 1957, and Sept 24, 1960, under the group protocol and followed through Dec 31, 1963. Clinical Material and Methods Only women with advancing disease previously untreated with hormones are eligible for protocol therapy, and all patients must be naturally or artificially postmenopausal. A randomization scheme based on

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Many studies have confirmed beneficial effects of androgens on breast cancer.
“Many studies subsequently confirmed the beneficial effects of androgens on breast cancer (165, 167-174, 251, 252).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [169]

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Authors: GOLDENBERG, I. S.
Corresponding author: I S GOLDENBERG
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1964-06-22
Volume: 188
Issue: 12
Pages: 1069
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1964.03060380037009
OpenAlex: W2417813231
Cited by: 114
References: 0
Citations by year: 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 5
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone propionate, breast cancer, hormone therapy, androgen therapy, metastatic breast cancer, inoperable breast cancer, postmenopausal women
MeSH terms: Breast Neoplasms, Castration, Female, Humans, Menopause, Neoplasms, Ovary, Prognosis, Testosterone, Biomedical Research, Testosterone Propionate

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Testosterone Propionate Therapy in Breast Cancer

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