Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

Hickey, T. E.; Robinson, J. L. L.; Carroll, J. S.; Tilley, W. D.

doi:10.1210/me.2012-1107

Cited by 298Estrogen and related hormone effectsProstate Cancer Treatment and ResearchBreast Cancer Treatment Studies

Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

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Hickey, T. E., Robinson, J. L. L., Carroll, J. S., Tilley, W. D.·2012·Molecular Endocrinology

DOI 10.1210/me.2012-1107PMC PMC3404296

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Abstract

Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.

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Androgens and AR expression have demonstrated both positive and negative outcomes in breast cancer.
“androgens and the expression of the AR have demonstrated both positive and negative outcomes in breast cancer as reviewed in (Hickey et al., 2012, McNamara and Sasano, 2015a, McNamara and Sasano, 2016).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Hickey et al., 2012

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Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma
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Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
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A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
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A phase II trial of abiraterone acetate plus prednisone in patients with triple-negative androgen receptor positive locally advanced or metastatic breast cancer (UCBG 12-1)
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Progesterone and Breast Cancer
Trabert, B. L., Sherman, M. E., Kannan, N., & Stanczyk, F. Z. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz001 · Cited by 273 · see citing works
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer
Hickey, T. E., Selth, L. A., Chia, K. M., Laven‐Law, G., Milioli, H. H., Roden, D. L., Jindal, S., Hui, M. N., Finlay-Schultz, J., Ebrahimie, E., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01168-7 · Cited by 261 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
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“normal mammary gland and breast cancer, androgens and the expression of the AR have demonstrated both positive and negative outcomes in breast cancer as reviewed in (Hickey et al., 2012; McNamara and Sasano, 2015a, 2016).”
Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver
Chang, C., Lee, S. O., Yeh, S., & Chang, T. M. (2013) · Oncogene · doi:10.1038/onc.2013.274 · Cited by 214 · see citing works
Regulators of genetic risk of breast cancer identified by integrative network analysis
Castro, M. A. A., de Santiago, I., Campbell, T. M., Vaughn, C. M., Hickey, T. E., Ross, E. M., Tilley, W. D., Markowetz, F. M., Ponder, B. A. J., & Meyer, K. B. (2015) · Nature Genetics · doi:10.1038/ng.3458 · Cited by 195 · see citing works
Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
Coutinho, I., Day, T. K., Tilley, W. D., & Selth, L. A. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0422 · Cited by 194 · see citing works
Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment
Chimento, A., Casaburi, I., Avena, P., Trotta, F., Luca, A. D., Rago, V., Pezzi, V., & Sirianni, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00807 · Cited by 183 · see citing works
Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1
Chang, C., Lee, S. O., Wang, R.-S., Yeh, S., & Chang, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109132 · Cited by 163 · see citing works
Androgen Receptor in Breast Cancer—Clinical and Preclinical Research Insights
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Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling
Pihlajamaa, P., Sahu, B., & Jänne, O. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1034 · Cited by 141 · see citing works
Androgen receptor phosphorylation: biological context and functional consequences
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Peters, A. A., Buchanan, G., Ricciardelli, C., Bianco‐Miotto, T., Centenera, M. M., Harris, J. M., Jindal, S., Segara, D., Li, J., Moore, N. L. T., et al. (2009) · Faculty of Health; Institute of Health and Biomedical Innovation · Cited by 1 · see citing works
Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer
Peters, A. A., Buchanan, G., Ricciardelli, C., Bianco‐Miotto, T., Centenera, M. M., Harris, J. M., Jindal, S., Segara, D., Li, J., Moore, N. L. T., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0452 · Cited by 406 · see citing works
The Divergent Function of Androgen Receptor in Breast Cancer; Analysis of Steroid Mediators and Tumor Intracrinology
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Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer
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Abstract 941: Targeting androgen receptor in estrogen receptor-negative breast cancer
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Authors: Hickey, T. E., Robinson, J. L. L., Carroll, J. S., & Tilley, W. D.
Affiliations: Hanson Institute (AU)
University of Cambridge (GB)
Corresponding author: Tilley, W. D.
ORCID: Hickey, T. E.
Robinson, J. L. L.
Carroll, J. S.
Tilley, W. D.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2012-08-01
Volume: 26
Issue: 8
Pages: 1252-1267
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2012-1107
PMC: PMC3404296
OpenAlex: W1974738527
Cited by: 289
References: 152
Citations by year: 2026: 10 · 2025: 12 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 40 · 2020: 16 · 2019: 19 · 2018: 27 · 2017: 18 · 2016: 29 · 2015: 22 · 2014: 30 · 2013: 24 · 2012: 1
FWCI: 3.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: U.S. Department of Defense (W81XWH-11-1-, W81XWH)
European Molecular Biology Organization
Cancer Research UK
University of Cambridge
National Breast Cancer Foundation
Medical Research Council
National Health and Medical Research Council (1008349)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords: androgen receptor, breast cancer, estrogen receptor alpha, luminal breast cancer, apocrine breast cancer, tumor suppressor, oncogenes, androgen signaling, transcriptional programs, therapeutic targeting
MeSH terms: Androgens, Animals, Breast Neoplasms, Female, Growth Inhibitors, Humans, Oncogenes, Receptors, Androgen, Signal Transduction, Genes, Tumor Suppressor, Mammary Glands, Human, Estrogen Receptor alpha

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Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

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