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Cited by 273Virology and Viral DiseasesRespiratory viral infections researchPoxvirus research and outbreaks

Altered Reactivity to Measles Virus: Atypical Measles in Children Previously Immunized With Inactivated Measles Virus Vaccines

Fulginiti, Vincent A.·1967·JAMA
DOI 10.1001/jama.1967.03130250057008
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Abstract

An atypical measles illness occurred in ten children who had received inactivated (killed) measles virus vaccine five to six years earlier. The illness is characterized by a two- to three-day prodrome of fever and complaints of pain (head, muscle, and abdomen, or both muscle and abdomen) followed by the development of a maculopapular rash with petechial, vesicular, and urticarial components. Peripheral edema and pneumonia occurred in almost all the children. In three instances, significant pleural effusions were noted. Serologic determinations established the diagnosis in all ten children, but measles virus was recovered from none of them.

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  • In animal models of other coronaviruses and prior inactivated RSV or measles vaccines, VAERD is usually linked to Th2-biased CD4+ responses with elevated IL-4, IL-5, or IL-13.

    “In animal models of infections with other coronaviruses and for previous whole-cell inactivated vaccines developed for respiratory syncytial virus and measles virus, VAERD has usually been associated with the development of T helper 2 cell (TH2 cell)-biased CD4+ T cell responses, with significantly increased levels of interleukin-4 (IL-4), IL-5 and/or IL-13 (refs12,126,165–174).”

    From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [169]

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Authors
Fulginiti, V. A.
Corresponding author
Fulginiti, Vincent A.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
1967-12-18
Volume
202
Issue
12
Pages
1075
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1967.03130250057008
OpenAlex
W4251623914
Cited by
273
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 27 · 2020: 14 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
16.77
Type
journal article
Language
en
Open access
closed
Locations
JAMA (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
Keywords
measles virus, atypical measles, inactivated measles vaccine, vaccine adverse reactions, maculopapular rash, pleural effusion, pneumonia, peripheral edema, children

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