Cited by 34Virology and Viral DiseasesPoxvirus research and outbreaksVaccine Coverage and Hesitancy

A systematic review of human-to-human transmission of measles vaccine virus

Greenwood, Kathryn P., Hafiz, Radwan, Ware, Robert S., Lambert, Stephen B.·2016·Vaccine

Abstract

Measles is one of the most contagious human diseases. Administration of the live attenuated measles vaccine has substantially reduced childhood mortality and morbidity since its licensure in 1963. The live but attenuated form of the vaccine describes a virus poorly adapted to replicating in human tissue, but with a replication yield sufficient to elicit an immune response for long-term protection. Given the high transmissibility of the wild-type virus and that transmission of other live vaccine viruses has been documented, we conducted a systematic review to establish if there is any evidence of human-to-human transmission of the live attenuated measles vaccine virus. We reviewed 773 articles for genotypic confirmation of a vaccine virus transmitted from a recently vaccinated individual to a susceptible close contact. No evidence of human-to-human transmission of the measles vaccine virus has been reported amongst the thousands of clinical samples genotyped during outbreaks or endemic transmission and individual case studies worldwide.

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Crossref · 10.1016/j.vaccine.2016.03.092

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  • No suitable tool for assessing risk of bias in noncomparative studies could be found in the literature.

    “No suitable tool for assessing noncomparative studies could be found in the literature and similar systematic reviews of human-to-human or animal-to-human transmission of infectious agents that we could find did not undertake a RoB assessment [21–24].”

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Authors
Greenwood, K. P., Hafiz, R., Ware, R. S., & Lambert, S. B.
Affiliations
  • The University of Queensland (AU)
  • Saudi Food and Drug Authority (SA)
  • Queensland Health (AU)
Corresponding author
Lambert, Stephen B.
Venue
Vaccine
Publisher
Elsevier BV
Published
2016-05
Volume
34
Issue
23
Pages
2531-2536
ISSN
0264-410X (ISSN-L)
OpenAlex
W2336309999
Cited by
34
References
62
Citations by year
2026: 5 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2
FWCI
0.50
Type
journal article
Language
en
Open access
closed
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
measles vaccine virus, live attenuated measles vaccine, human-to-human transmission, vaccine virus shedding, close contacts, genotyping, measles outbreak, vaccine safety
MeSH terms
Genotype, Humans, Measles, Measles Vaccine, Measles virus, Vaccines, Attenuated

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